老年男性睾酮水平与代谢综合征的关系(3)
第1页 |
参见附件。
综上所述,老年男性代谢综合征患者具有相对低下的睾酮水平,低睾酮水平增加MS的患病风险,睾酮水平提高有望于改善胰岛素抵抗、内脏性肥胖及血脂的调控。
参考文献
[1] Jeong S M, Ham B K, Park M G, et al. Effect of testosterone replacement treatment in testosterone deficiency syndrome patients with metabolic syndrome[J]. Korean J Urol,2011,52(8):566-571.
[2] 康冬梅,叶山东.中老年男性血清睾酮水平与代谢综合征的相关性[J].医学综述,2011,17(17):2669-2671.
[3] Laaksonen D E, Niskanen L, Punnonen K, et al. Sex hormones, inflammation and the metabolic syndrome: a population- based study[J]. Eur J Endocrinol,2003,149(6):601-608.
[4] Blouin K, Despres J P, Couillard C, et al. Contribution of age and declining androgen levels to features of the metabolic syndrome in men[J]. Metabolism,2005,54(8):1034-1040.
[5] Kaplan S A, Meehan A G, Shah A, et al. The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men?[J]. J Urol,2006,176(6):1524-1528.
[6] Boucher J, Masri B, Apelin, et al. A newly identified adipokine up regulated by insulin and obesity[J]. Endocrinology,2005,146(4):1764-1771.
[7] Wang C, Jackson G, Jones T H, et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes[J]. Diabetes Care,2011,34(7):1669-1675.
[8] Mikinen J I, Antti P,Kerttu I, et al. endogenous testosterone and serum lipids in middle-aged men[J]. Atherosclerosis,2008,197(2):688-693.
[9] Svartberg J, Von Muhlen D, Schirmer H, et al. Association of endogenous testosterone with blood pressure and left ventricular mass in men[J]. Eur J Endocrinol,2004,150(1):65-71.
(收稿日期:2012-09-29) (本文编辑:王宇)
您现在查看是摘要介绍页,详见PDF附件(2826kb)。