老年男性睾酮水平与代谢综合征的关系(1)
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【摘要】 目的:探讨老年男性血清睾酮水平与代谢综合征(MS)的关系。方法:收集133例60~89岁男性病例,分成MS组72例和NMS组61例,分别测定患者的血清睾酮、雌二醇、甘油三酯、高密度脂蛋白、空腹血糖、空腹胰岛素,并以稳态模式评估胰岛素抵抗指数(HOMA-IR)评价患者的胰岛素敏感性。比较两组的睾酮、雌二醇/睾酮,分析血清中睾酮与代谢综合征的相关性。结果: MS组睾酮水平显著降低,而雌二醇/睾酮明显增高,比较差异具有统计学意义(P<0.01),随着MS组分增多,睾酮水平下降明显。在MS组中睾酮水平与年龄、腰围、体重指数、TG、HOMA-IR成负相关,与HDL-C正相关。结论:老年男性患者血清中低睾酮水平可增加MS的患病风险。
【关键词】 代谢综合征; 睾酮; 老年男性
Relationship between Serum Testosterone and Metabolic Syndrome in Elderly Men/ZHU Wen-jing, KANG Dong-mei, ZHU Xiang, et al.//Medical Innovation of China,2012,9(33):003-005
【Abstract】 Objective: To investigate the relationship between serum testosterone and metabolic syndrome(MS) in elderly men. Method: 133 elderly men aged 60-89 years were divided into two groups: MS (72 cases) and NMS (61 cases) groups. Serum testosterone, estradiol, triglycerides, high-density lipoprotein cholesterol(HDL-C), fasting blood glucose, fasting insulin were measured, and insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Serum testosterone and estradiol/testosterone between the two groups were compared, the correlation between serum testosterone and metabolic syndrome were analyzed. Result: Compared between the two groups, serum testosterone level was significantly lower in MS group than that in NMS group, and estradiol/testosterone obviously increased, the difference was statistically significant(P<0.01). Serum testosterone level decreased significantly with MS components increased. Correlation analyses showed that testosterone level was negatively associated with age, waist circumference, body mass index, TG and HOMA-IR in MS group, while it was positively associated with HDL-C. Conclusion: Low serum testosterone level appears to increase the risk for the developments of MS in elderly men ......
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