结核性脑膜炎患儿脑脊髓液中腺苷脱氨酶活性测定的临床意义(1)
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【摘要】 目的:评价结核性脑膜炎患儿脑脊髓液中腺苷脱氨酶(CSF-ADA)活性对临床诊断意义及疗效判断价值。方法:选择122例住院患儿为研究对象,56例结核性脑膜炎患者为A组;66例非结核性脑膜炎患者为对照组,其中细菌性脑膜炎32例为B组,病毒性脑膜炎34例为C组,采用酶耦联Trinder法测定患儿治疗前CSF-ADA活性,56例结核性脑膜炎患儿于抗结核治疗后2周和6周时分别检测CSF-ADA。结果:A组CSF-ADA活性为(11.8±4.4)U/L,B组为(6.1±2.8)U/L,C组为(4.9±3.1)U/L,与A组比较差异有统计学意义(F=45.150,P=0.000)。取CSF-ADA≥8 U/L作为临界值时鉴别结核性脑膜炎与非结核性脑膜炎价值最高,灵敏度为87.72%,特异度为90.77%。随着患儿病情好转,CSF-ADA活性逐渐降低。结论:CSF-ADA活性≥8U/L可作为诊断结核性脑膜炎的一项辅助诊断指标,抗结核治疗后CSF-ADA活性可作为疗效判断的参考指标。
【关键词】 腺苷脱氨酶; 脑膜炎; 结核; 脑脊髓液
Clinical Significance of Cerebrospinal Fluid Adenosine Deaminase of Children with Tuberculous Meningitis/CHENG Jin-ling.//Medical Innovation of China,2012,9(33):027-028
【Abstract】 Objective: Evaluation of tuberculous meningitis with cerebrospinal fluid of adenosine deaminase(CSF-ADA) activity to clinical diagnosis significance and effect of value judgment. Method: To choose 122 cases hospitalized children as the research object, 56 cases of tuberculous meningitis was the case group (group A). 66 cases of meningitis of n/med tuberculosis sex as control group, including bacterial meningitis 32 cases (group B), and viral meningitis 34 cases (C group), using enzyme coupling Trinder spectrometry to analyze CSF-ADA activity before treatment. 56 cases of tuberculous meningitis in antitubercular treatment children after 2 weeks and six weeks respectively detection CSF-ADA. Result: The CSF-ADA activity of group A was(11.8±4.4) U/L, compared with group B(6.1±2.8) U/L, group C(4.9±3.1) U/L, there was a significant difference meaning (F=45.150, P=0.000). Taking the CSF-ADA≥8 U/L as critical value in identification of tuberculous meningitis had the highest value, and sensitivity was 87 ......
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