血液灌流联合血液透析对尿毒症钙磷代谢及皮肤瘙痒的影响(1)
【摘要】 目的：探讨血液灌流联合血液透析对尿毒症患者钙磷代谢及皮肤瘙痒症状的影响。方法：选择42例尿毒症患者为研究对象。将42例患者按照随机数字表法分为观察组和对照组。观察组18例，接受血液透析联合血液灌流治疗；对照组24例，接受单纯血液透析治疗。比较两组治疗前后钙、磷、皮肤瘙痒情况及生活质量。结果：治疗4、8周后观察组钙磷乘积明显较治疗前改善(P<0.01)，且较同期对照组改善明显，差异有统计学意义(P<0.01)；治疗4、8周后观察组血清磷水平明显较治疗前改善(P<0.01)，且较同期对照组改善明显，差异有统计学意义(P<0.01)。治疗后4、8周观察组皮肤瘙痒情况明显较治疗前好转，且较同期对照组患者皮肤瘙痒情况改善明显，差异有统计学意义(P<0.001)；治疗后观察组生活质量明显高于对照组，差异有统计学意义(P<0.001)。结论：血液灌流联合血液透析可有效纠正尿毒症患者血钙磷代谢紊乱，明显减轻患者皮肤瘙痒症状。
【关键词】 尿毒症； 血液灌流； 血液透析； 疗效
, 百拇医药
【Abstract】 Objective：To study influence of blood perfusion combined with hemodialysis on calcium and phosphorus metabolism and skin pruritus symptoms of patients with uremia. Method：42 uremia patients were selected as the research object.According to random number table method 42 patients were randomly divided into observation group and control group. Observation group： 18 patients， treated with hemodialysis combing blood perfusion；Control group：24 cases， pure hemodialysis therapy. Calcium， phosphorus， skin pruritus conditions and quality of life of two groups before and after the treatment were compared. Result：4 weeks， 8 weeks after treatment，serum calcium level of observation group was obviously improved than before the treatment(P<0.01)，and the control group improved significantly during this period， and there were statistically significant difference(P<0.01)；4 weeks，8 weeks after treatment，serum phosphorus levels of observation group was obviously improved before the treatment (P<0.01)， and the control group improved significantly during this period， and there were significant difference(P<0.01). 4 weeks and 8 weeks after treatment skin pruritus in observation group were significantly better than before treatment，and also improved obviously than skin pruritus condition of patients in the control group at the same period，and there were statistically significant difference(P<0.001).The quality of life after treatment in observation group was obviously higher than that of control group，and the difference was statistically significant(P<0.001).Conclusion：Blood perfusion combined with hemodialysis can effectively correct uremia patients’ blood calcium and phosphorus metabolism disorder，and significantly reduce patients’ skin pruritus symptoms.
【Key words】 Uremia； Blood perfusion； Hemodialysis； Curative effect
随着血液透析运用于尿毒症的治疗，尿毒症患者的可生存时间明显得到延长[1]，而皮肤瘙痒等临床症状的发生率也随之增高[2]。文献报道其发生率高达50%以上[3]，可严重影响患者睡眠质量和生活质量，长期可导致患者罹患抑郁症等心理疾病。单纯血液透析对小分子毒素的清除作用较理想，但对中大分子的毒素清除效果则欠佳[4-6]。本院将血液灌流联合血液透析疗法应用于尿毒症患者的临床治疗中，效果满意。现将结果报道如下。, 百拇医药(冯敏坚 刘新 王文凤)
【关键词】 尿毒症； 血液灌流； 血液透析； 疗效
, 百拇医药
【Abstract】 Objective：To study influence of blood perfusion combined with hemodialysis on calcium and phosphorus metabolism and skin pruritus symptoms of patients with uremia. Method：42 uremia patients were selected as the research object.According to random number table method 42 patients were randomly divided into observation group and control group. Observation group： 18 patients， treated with hemodialysis combing blood perfusion；Control group：24 cases， pure hemodialysis therapy. Calcium， phosphorus， skin pruritus conditions and quality of life of two groups before and after the treatment were compared. Result：4 weeks， 8 weeks after treatment，serum calcium level of observation group was obviously improved than before the treatment(P<0.01)，and the control group improved significantly during this period， and there were statistically significant difference(P<0.01)；4 weeks，8 weeks after treatment，serum phosphorus levels of observation group was obviously improved before the treatment (P<0.01)， and the control group improved significantly during this period， and there were significant difference(P<0.01). 4 weeks and 8 weeks after treatment skin pruritus in observation group were significantly better than before treatment，and also improved obviously than skin pruritus condition of patients in the control group at the same period，and there were statistically significant difference(P<0.001).The quality of life after treatment in observation group was obviously higher than that of control group，and the difference was statistically significant(P<0.001).Conclusion：Blood perfusion combined with hemodialysis can effectively correct uremia patients’ blood calcium and phosphorus metabolism disorder，and significantly reduce patients’ skin pruritus symptoms.
【Key words】 Uremia； Blood perfusion； Hemodialysis； Curative effect
随着血液透析运用于尿毒症的治疗，尿毒症患者的可生存时间明显得到延长[1]，而皮肤瘙痒等临床症状的发生率也随之增高[2]。文献报道其发生率高达50%以上[3]，可严重影响患者睡眠质量和生活质量，长期可导致患者罹患抑郁症等心理疾病。单纯血液透析对小分子毒素的清除作用较理想，但对中大分子的毒素清除效果则欠佳[4-6]。本院将血液灌流联合血液透析疗法应用于尿毒症患者的临床治疗中，效果满意。现将结果报道如下。, 百拇医药(冯敏坚 刘新 王文凤)