妊娠期高血压疾病治疗中解痉与降压疗效的分析(1)
【摘要】 目的:探讨硫酸镁治疗妊娠期高血压疾病对解痉与降压的疗效。方法:选取本院2012年8月-2014年8月接收的112例妊娠期高血压疾病患者,对其采用硫酸镁法治疗,观察并记录治疗前后平均血压、呼吸、脉率、尿量、膝反射、尿酸、尿素氮和肌酐等多项指标,分析硫酸镁法治疗对解痉与降压的疗效。结果:112例妊娠高血压患者平均血压相对于治疗前明显降低,治疗前后比较差异有统计学意义(P<0.05);尿酸、尿素氮和肌酐三项指标与治疗前相比明显下降,治疗前后比较差异有统计学意义(P<0.05);显效74例(66.07%),有效32例(28.57%),无效6例(5.36%),总有效率94.64%,并发症发生率为5.36%。结论:硫酸镁在临床上治疗妊娠期高血压疾病有良好的效果,能够有效降压和解痉,且并发症较少,在临床上具有应用和推广价值。
【关键词】 妊娠期高血压疾病; 解痉; 降血压
【Abstract】 Objective: To explore the efficacy of spasmolysis and antihypertension in the treatment of pregnancy-induced hypertension by magnesium sulfate. Method:122 patients were selected with pregnancy-induced hypertension who were admitted to our hospital from August 2012 to August 2014 and received the treatment of magnesium sulfate. Mean blood pressure, respiration, pulse rate, urinary volume, knee jerk, Uric acid, urea nitrogen and creatinine were observed before and after treatment.The efficacy of spasmolysis and antihypertension in the treatment of pregnancy-induced hypertension by magnesium sulfate were analyzed. Result: Compared before and after the treatment, 122 patients’ mean blood pressure significantly reduced, the difference was statistically significant(P<0.05);Uric acid, urea nitrogen,and creatinine also significantly reduced, the difference was statistically significant(P<0.05).The significant effective were 74 patients(66.07%),the effective were 32 patients(28.57%),the ineffective were 6 patients(5.36%),total effective rate was 94.64%,incidence of complication rate 5.36%.Conclusion: Magnesium sulfate in the treatment of pregnancy-induced hypertension has a favorable effect and can effectively reduce the blood pressure and relive spasm. Furthermore, incidence rate of complication rate is reduced. It’s worthy of clinical promotion and application.
, 百拇医药
【Key words】 Pregnancy-induced hypertension; Spasmolysis; Antihypertension
妊娠期高血压疾病是妊娠期发生率很高的并发症,严重威胁母婴健康,已经成为我国第二大孕妇死亡的疾病[1]。因此,降低妊娠期高血压疾病发病率对降低孕妇围生儿死亡率具有重要意义[2]。该疾病的临床表现主要有高血压、蛋白尿和小动脉痉挛,因此控制血压和解除血管痉挛是临床上主要的治疗手段[3-4]。临床上比较常用于妊娠期高血压疾病的治疗药物为硫酸镁,它具有良好的抗惊厥和降血压的功能。为了进一步探讨硫酸镁在妊娠高血压治疗中对解痉和降压的疗效,本文选取了本院2012年8月-2014年8月接收的112例妊娠期高血压疾病患者作为研究对象,报告如下。
1 资料与方法
1.1 一般资料 选取本院2012年8月到2014年8月接收的112例妊娠高血压患者,年龄20~38岁,平均(27.4±8.6)岁。其中初产妇82例,经产妇30例,伴有原发性高血压患者22例。
, 百拇医药
1.2 方法 112例妊娠期高血压疾病患者在硫酸镁治疗前1 W内停止服用降压药,在治疗前后3 d分别测量血压2次/d,计算治疗前后3 d血压的平均值,同时常规检测用药期间呼吸、脉率、尿量、膝反射、尿酸、尿素氮和肌酐等指标,做好数据统计和记录。硫酸镁的治疗方法:硫酸镁注射液(江苏正大天晴药业股份有限公司,国药准字号H32022858),采用静脉注射加肌肉注射。用药第一阶段,20 mL 25%硫酸镁与20 mL 10%葡萄糖溶液混合,静脉推注5~10 min。用药第二阶段,60 mL 25%硫酸镁与50 mL 5%葡萄糖溶液混合,以1~2 g/h的滴速进行静脉滴注。根据患者血压情况,决定是否加用肌肉注射。给予20 mL 25%硫酸镁与利多卡因混合液臀部肌肉注射,1~2次/d;或者给予20 mL 丹参注射液与500 mL低分子左旋糖酐混合液进行静脉滴注。硫酸镁静脉给药并结合肌肉注射,每天每位患者治疗药量最大不得超过25 g。做好临床疗效和产后并发症的统计和记录。另外加强护理,预防感染,纠正心功能不全和肾功能不全,必要时适时终止妊娠。, 百拇医药(孙梅芳)
【关键词】 妊娠期高血压疾病; 解痉; 降血压
【Abstract】 Objective: To explore the efficacy of spasmolysis and antihypertension in the treatment of pregnancy-induced hypertension by magnesium sulfate. Method:122 patients were selected with pregnancy-induced hypertension who were admitted to our hospital from August 2012 to August 2014 and received the treatment of magnesium sulfate. Mean blood pressure, respiration, pulse rate, urinary volume, knee jerk, Uric acid, urea nitrogen and creatinine were observed before and after treatment.The efficacy of spasmolysis and antihypertension in the treatment of pregnancy-induced hypertension by magnesium sulfate were analyzed. Result: Compared before and after the treatment, 122 patients’ mean blood pressure significantly reduced, the difference was statistically significant(P<0.05);Uric acid, urea nitrogen,and creatinine also significantly reduced, the difference was statistically significant(P<0.05).The significant effective were 74 patients(66.07%),the effective were 32 patients(28.57%),the ineffective were 6 patients(5.36%),total effective rate was 94.64%,incidence of complication rate 5.36%.Conclusion: Magnesium sulfate in the treatment of pregnancy-induced hypertension has a favorable effect and can effectively reduce the blood pressure and relive spasm. Furthermore, incidence rate of complication rate is reduced. It’s worthy of clinical promotion and application.
, 百拇医药
【Key words】 Pregnancy-induced hypertension; Spasmolysis; Antihypertension
妊娠期高血压疾病是妊娠期发生率很高的并发症,严重威胁母婴健康,已经成为我国第二大孕妇死亡的疾病[1]。因此,降低妊娠期高血压疾病发病率对降低孕妇围生儿死亡率具有重要意义[2]。该疾病的临床表现主要有高血压、蛋白尿和小动脉痉挛,因此控制血压和解除血管痉挛是临床上主要的治疗手段[3-4]。临床上比较常用于妊娠期高血压疾病的治疗药物为硫酸镁,它具有良好的抗惊厥和降血压的功能。为了进一步探讨硫酸镁在妊娠高血压治疗中对解痉和降压的疗效,本文选取了本院2012年8月-2014年8月接收的112例妊娠期高血压疾病患者作为研究对象,报告如下。
1 资料与方法
1.1 一般资料 选取本院2012年8月到2014年8月接收的112例妊娠高血压患者,年龄20~38岁,平均(27.4±8.6)岁。其中初产妇82例,经产妇30例,伴有原发性高血压患者22例。
, 百拇医药
1.2 方法 112例妊娠期高血压疾病患者在硫酸镁治疗前1 W内停止服用降压药,在治疗前后3 d分别测量血压2次/d,计算治疗前后3 d血压的平均值,同时常规检测用药期间呼吸、脉率、尿量、膝反射、尿酸、尿素氮和肌酐等指标,做好数据统计和记录。硫酸镁的治疗方法:硫酸镁注射液(江苏正大天晴药业股份有限公司,国药准字号H32022858),采用静脉注射加肌肉注射。用药第一阶段,20 mL 25%硫酸镁与20 mL 10%葡萄糖溶液混合,静脉推注5~10 min。用药第二阶段,60 mL 25%硫酸镁与50 mL 5%葡萄糖溶液混合,以1~2 g/h的滴速进行静脉滴注。根据患者血压情况,决定是否加用肌肉注射。给予20 mL 25%硫酸镁与利多卡因混合液臀部肌肉注射,1~2次/d;或者给予20 mL 丹参注射液与500 mL低分子左旋糖酐混合液进行静脉滴注。硫酸镁静脉给药并结合肌肉注射,每天每位患者治疗药量最大不得超过25 g。做好临床疗效和产后并发症的统计和记录。另外加强护理,预防感染,纠正心功能不全和肾功能不全,必要时适时终止妊娠。, 百拇医药(孙梅芳)