【摘要】 目的：评价重度肺老化在高分辨率CT(HRCT)上的影像表现及与临床危险因素之间的相关性。方法：搜集具有完整病史且经HRCT诊断为重度肺老化的患者60例和无肺老化患者56例进行研究。选择相关危险因素进行每个单因素Logistic回归分析，再将有统计学意义的因素，纳入多因素回归分析确定与重度肺老化相关的独立危险因素。结果：重度肺老化在HRCT上主要表现为肺气肿、肺间质性改变、肺内空气潴留等征象。高年龄、慢性支气管炎、过敏病史、吸烟、粉尘、冠心病、高血压是重度肺老化发生的危险因素，是纳入多因素logistic回归分析的有统计学意义的变量。结论：HRCT可作为肺老化检查和分度的首选检查方法；年龄≥70岁、慢性支气管炎、吸烟、粉尘、高血压病是肺老化的独立发病危险因素。

    【关键词】 肺老化； 危险因素； 高分辨CT

    【Abstract】 Objective： To evaluate the sign of severe lung aging by HRCT and related risk factors to predict the value of illness.Method：115 hospitalized patients examined lung HRCT were screened out with collecting whole clinical date. Among them there are 56 patients without lung aging (non- lung aging) and 60 patients with severe lung aging. Single and multi-logistic regression analyses were used to assess the relationship between severe lung aging and risk factors. Result： The severe lung aging features of HRCT are Emphysema pulmonum ......