【摘要】 目的：探讨雷替曲塞联合奥沙利铂治疗晚期结直肠癌患者的临床疗效。方法：39例老年晚期大肠癌患者随机分为两组，治疗组20例，给予雷替曲塞联合奥沙利铂方案，每3周重复1次。对照组19例，予以替吉奥联合奥沙利铂方案，每3周重复1次。结果：治疗组与对照组有效率(RR)分别为60.00%与26.32%；中位疾病进展时间(TTP)分别为8.1个月与4.9个月，两组疗效比较，差异有统计学意义(P<0.05)。治疗组不良反应粒细胞减少及转氨酶增高例数较对照组多，治疗组呕吐患者明显少于对照组，比较差异有统计学意义(P<0.05)。结论：应用雷替曲塞联合奥沙利铂方案治疗老年晚期结直肠癌有一定的疗效。

    【关键词】 雷替曲塞； 奥沙利铂； 晚期结直肠癌

    【Abstract】 Objective： To observe the efficacy of the combined raltitrexed plus oxalplatin in the treatment of senile advanced colorectal carcinoma. Method： Thirty-nine advanced colorectal cancer patients were divided into two groups. The treatment group (n=20) was administered intravenously raltitrexed plus oxaliplatin regimen. The control group (n=19) was administered S1 plus Oxaliplatin regimen. Result： All the patients in the treatment group and control group were evaluated. Effective rate of the treatment group and control group was 60.00% and 26.32% ......