药师干预模式对服用华法林患者的依从性、疗效和生活质量的影响(1)
【摘要】 目的：研究临床药师干预模式对华法林患者依从性、临床疗效以及生活质量的影响。方法：选取本院2013年6月-2014年6月收治的60例慢性房颤患者作为研究对象，按出院顺序随机分为观察组与对照组，每组各30例。观察组采用临床药师干预模式，对照组无药师参与，对比两组患者用药依从性、疗效以及生活质量的差异。结果：观察组的总依从性为86.67%，明显高于对照组的56.67%，两组比较差异有统计学意义(P<0.05)；观察组血栓出现率以及总出血率分别为0、6.67%，明显低于对照组的13.33%和26.67%，两组比较差异有统计学意义(P<0.05)；观察组出院1年后各项评分均显著高于对照组，差异有统计学意义(P<0.05)。结论：对接受华法林治疗患者采取药师干预模式可以提高其用药依从性以及疗效，并提高患者的生存质量，具有较高的临床推广价值。
【关键词】 临床药师干预模式； 华法林； 依从性； 疗效； 生活质量
The Influence of Clinical Pharmacist Interventions on the Compliance，Efficacy and Life Quality of Taking Warfarin/WU Shi-quan，TAN Cai-hong，DONG Yu-hua.//Medical Innovation of China，2015，12(16)：016-018
, 百拇医药
【Abstract】 Objective：To study the influence of clinical pharmacist intervention model on compliance，clinical efficacy and life quality of warfarin.Method：60 patients with chronic AF were selected in our hospital from June 2013 to June 2014 as the research object，and were divided into observation group and control group according to the discharge order，30 cases in each group.The observation group was treated with clinical pharmacist intervention，control group was treated without pharmacists，drug compliance，efficacy and life quality of two groups were compared.Result：The total compliance of the observation group was 86.67%，significantly higher than the control group of 63.33%，the difference was statistically significant(P<0.05)； occurrence rates of thrombosis and bleeding rates of observation group were 0 and 6.67%，significantly lower than control group of 13.33% and 26.67%，the differences were statistical significance(P<0.05)； when the observation group discharged after 1 years，the scores were significantly higher than those in the control group，the differences were statistically significant(P<0.05).Conclusion：Pharmacists intervention mode to accept warfarin treatment can improve the medication compliance and curative effect，improve the quality of life of patients，has high clinical value.
, 百拇医药
【Key words】 Clinical pharmacist intervention mode； Warfarin； Compliance； Curative effect； Quality of life
First-author’s address：The People’s Hospital of Gaoyao，Gaoyao 526040，China
doi：10.3969/j.issn.1674-4985.2015.16.006
心房震颤属于持续性的心率失常，占心率失常患者的30%，为了避免心房震颤患者出现栓塞，通常采用口服华法林的方式抑制血栓产生[1]。华法林为唯一口服抗凝血药，是长期抗凝血患者的主要选择。我国华法林用药比例较低，住院人数低于10%，考虑可能和其治疗窗窄、药理作用复杂、影响因素多等特点有关，因此，采取正确、有效的药学监护对患者的治疗尤为重要。对此，本文选取2013年6月-2014年6月在本院心血管中心出院带药使用华法林患者60例，采取药师干预模式，并与无药师干预的对比，主要结果如下。
1 资料与方法
1.1 一般资料 本次研究患者均于2013年6月-2014年6月在广东省高要市人民医院接受治疗，60例患者均为心血管中心出院带药患者，其中男33例，女27例，年龄39～78岁，平均(59.21±8.14)岁，按出院顺序将上述患者随机分为观察组与对照组，每组各30例，均符合房颤诊断标准。以上患者均无心理、精神疾病史，近期未接受精神类药物，自愿参加本研究。同时年龄、性别等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(伍世全 谭彩虹 董玉华)
【关键词】 临床药师干预模式； 华法林； 依从性； 疗效； 生活质量
The Influence of Clinical Pharmacist Interventions on the Compliance，Efficacy and Life Quality of Taking Warfarin/WU Shi-quan，TAN Cai-hong，DONG Yu-hua.//Medical Innovation of China，2015，12(16)：016-018
, 百拇医药
【Abstract】 Objective：To study the influence of clinical pharmacist intervention model on compliance，clinical efficacy and life quality of warfarin.Method：60 patients with chronic AF were selected in our hospital from June 2013 to June 2014 as the research object，and were divided into observation group and control group according to the discharge order，30 cases in each group.The observation group was treated with clinical pharmacist intervention，control group was treated without pharmacists，drug compliance，efficacy and life quality of two groups were compared.Result：The total compliance of the observation group was 86.67%，significantly higher than the control group of 63.33%，the difference was statistically significant(P<0.05)； occurrence rates of thrombosis and bleeding rates of observation group were 0 and 6.67%，significantly lower than control group of 13.33% and 26.67%，the differences were statistical significance(P<0.05)； when the observation group discharged after 1 years，the scores were significantly higher than those in the control group，the differences were statistically significant(P<0.05).Conclusion：Pharmacists intervention mode to accept warfarin treatment can improve the medication compliance and curative effect，improve the quality of life of patients，has high clinical value.
, 百拇医药
【Key words】 Clinical pharmacist intervention mode； Warfarin； Compliance； Curative effect； Quality of life
First-author’s address：The People’s Hospital of Gaoyao，Gaoyao 526040，China
doi：10.3969/j.issn.1674-4985.2015.16.006
心房震颤属于持续性的心率失常，占心率失常患者的30%，为了避免心房震颤患者出现栓塞，通常采用口服华法林的方式抑制血栓产生[1]。华法林为唯一口服抗凝血药，是长期抗凝血患者的主要选择。我国华法林用药比例较低，住院人数低于10%，考虑可能和其治疗窗窄、药理作用复杂、影响因素多等特点有关，因此，采取正确、有效的药学监护对患者的治疗尤为重要。对此，本文选取2013年6月-2014年6月在本院心血管中心出院带药使用华法林患者60例，采取药师干预模式，并与无药师干预的对比，主要结果如下。
1 资料与方法
1.1 一般资料 本次研究患者均于2013年6月-2014年6月在广东省高要市人民医院接受治疗，60例患者均为心血管中心出院带药患者，其中男33例，女27例，年龄39～78岁，平均(59.21±8.14)岁，按出院顺序将上述患者随机分为观察组与对照组，每组各30例，均符合房颤诊断标准。以上患者均无心理、精神疾病史，近期未接受精神类药物，自愿参加本研究。同时年龄、性别等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(伍世全 谭彩虹 董玉华)