术后早期肠内免疫营养对老年胃癌患者营养状况及免疫功能的影响(1)
【摘要】 目的：探析术后早期肠内免疫营养对老年胃癌患者营养状况及免疫功能所造成影响。方法：选择本院2011年4月-2014年4月收治82例胃癌患者作为研究对象，观察组行肠内营养，对照组予以肠外营养，对比两组术前及术后第8天TFN(转铁蛋白)、preAlb(前白蛋白)、Alb(血清白蛋白)、体重等营养情况指标及IgG、IgM、IgA、CD4+、CD8+、CD4+/CD8+等免疫功能指标。结果：两组术前TFN、preAlb、Alb、体重的比较差异均无统计学意义(P>0.05)；术后第8天，两组各指标均有所下降，但观察组依然高于对照组，与术前各指标值更接近，两组比较差异有统计学意义(P<0.05)；两组术前IgG、IgM、IgA、CD4+、CD8+、CD4+/CD8+的比较差异均无统计学意义(P>0.05)；术后第8天，两组各指标均有所降低，但观察组各指标水平依然高于对照组，与术前各指标值更接近，两组比较差异有统计学意义(P<0.05)。结论：术后早期进行肠内营养可有效改善患者术后营养状况及免疫功能，促进术后恢复，具有较高营养价值。
, http://www.100md.com 【关键词】 肠内免疫营养； 胃癌； 营养状况； 免疫功能
【Abstract】 Objective：To explore the effect of early enteral immune on nutritional status and immune function in elderly patients with gastric cancer after operation.Method：82 gastric cancer patients were selected in our hospital from April 2011 to April 2014 as the research object，and divided into two groups，41 cases in each group.The observation group was trested enteral nutrition，the control group was given parenteral nutrition，the nutrition index of two groups TFN (transferrin)，preAlb (prealbumin)，Alb (serum albumin)，weight，and immune function index of IgG，IgM，IgA，CD4+，CD8+，CD4+/CD8+ of patients before surgery and eighth days after surgery were compared.Result：TFN，preAlb，Alb，and weight of two groups during preoperative showed no significant difference (P>0.05).Eighth days after operation，two groups were decreased，but in observation group was still significantly higher than that in control group，which was closer to preoperative indexes，the differences were statistically significant(P<0.05).Before the operation，IgG，IgM，IgA，CD4+，CD8+，CD4+/CD8+ of two groups showed no significant difference (P>0.05).Eighth days after operation，two groups of indexes were lower，but each index level in observation group was significantly higher than that in control group and the index value was closer to the preoperative，the differences were statistically significant(P<0.05).Conclusion：Early enteral immune nutrition can effectively improve nutritional status and immune function in elderly patients，promote the postoperative recovery，has high nutritional value.
, 百拇医药
【Key words】 Immune enteral nutrition； Gastric cancer； Nutritional status； Immune function
First-author’s address：The People’s Hospital of Puning，Puning 515300，China
doi：10.3969/j.issn.1674-4985.2015.17.021
胃癌在全球范围内发病率均较高，其中以超过50岁人群为主要发病群体。老年胃癌患者基础营养状况差，受到手术创伤、术后禁食、肿瘤消耗等因素影响，机体容易出现高分解代谢状态及营养不良，致使免疫功能受到抑制，伤口愈合速度受到影响并引发各种并发症，不利于术后恢复[1]。研究表明，术后早期应用膳食纤维、核苷酸、ω-3多不饱和脂肪酸、谷氨酰胺、精氨酸等可有效缓解患者营养不良及免疫抑制状态，降低并发症发生率，促进伤口愈合进而改善预后[2]。本文选择本院2011年4月-2014年4月期间所收治82例胃癌患者作为研究对象，观察术后早期肠内免疫营养对老年胃癌患者营养状况及免疫功能所造成影响，报告如下。, 百拇医药(罗晓东 李晓辉)
, http://www.100md.com 【关键词】 肠内免疫营养； 胃癌； 营养状况； 免疫功能
【Abstract】 Objective：To explore the effect of early enteral immune on nutritional status and immune function in elderly patients with gastric cancer after operation.Method：82 gastric cancer patients were selected in our hospital from April 2011 to April 2014 as the research object，and divided into two groups，41 cases in each group.The observation group was trested enteral nutrition，the control group was given parenteral nutrition，the nutrition index of two groups TFN (transferrin)，preAlb (prealbumin)，Alb (serum albumin)，weight，and immune function index of IgG，IgM，IgA，CD4+，CD8+，CD4+/CD8+ of patients before surgery and eighth days after surgery were compared.Result：TFN，preAlb，Alb，and weight of two groups during preoperative showed no significant difference (P>0.05).Eighth days after operation，two groups were decreased，but in observation group was still significantly higher than that in control group，which was closer to preoperative indexes，the differences were statistically significant(P<0.05).Before the operation，IgG，IgM，IgA，CD4+，CD8+，CD4+/CD8+ of two groups showed no significant difference (P>0.05).Eighth days after operation，two groups of indexes were lower，but each index level in observation group was significantly higher than that in control group and the index value was closer to the preoperative，the differences were statistically significant(P<0.05).Conclusion：Early enteral immune nutrition can effectively improve nutritional status and immune function in elderly patients，promote the postoperative recovery，has high nutritional value.
, 百拇医药
【Key words】 Immune enteral nutrition； Gastric cancer； Nutritional status； Immune function
First-author’s address：The People’s Hospital of Puning，Puning 515300，China
doi：10.3969/j.issn.1674-4985.2015.17.021
胃癌在全球范围内发病率均较高，其中以超过50岁人群为主要发病群体。老年胃癌患者基础营养状况差，受到手术创伤、术后禁食、肿瘤消耗等因素影响，机体容易出现高分解代谢状态及营养不良，致使免疫功能受到抑制，伤口愈合速度受到影响并引发各种并发症，不利于术后恢复[1]。研究表明，术后早期应用膳食纤维、核苷酸、ω-3多不饱和脂肪酸、谷氨酰胺、精氨酸等可有效缓解患者营养不良及免疫抑制状态，降低并发症发生率，促进伤口愈合进而改善预后[2]。本文选择本院2011年4月-2014年4月期间所收治82例胃癌患者作为研究对象，观察术后早期肠内免疫营养对老年胃癌患者营养状况及免疫功能所造成影响，报告如下。, 百拇医药(罗晓东 李晓辉)