绝经后膝骨关节炎发生发展与骨密度的相关性研究(1)
【摘要】 目的：通过分析和比较绝经后正常人群以及不同程度膝骨关节炎(KOA)患者骨密度及骨代谢指标，探讨绝经后女性KOA对骨密度的影响。方法：依据Lequesne指数测试得分情况，将166名绝经后妇女分成正常、轻、中、重组，并测定双光能X线骨密度、骨代谢指标(骨特异性碱性磷酸酶BAP、Ⅰ型胶原交联C末端肽CTX-1)以及拍摄膝关节站立位X线片，观察不同分组中各项指标的变化。结果：绝经后KOA患者与正常人群比较，骨密度减低及患骨质疏松症人数之和(即T值≤-1人数)占各组总人数的比存在差异(P<0.05)。BAP值在不同程度KOA患者中存在差异(P<0.05)，CTX-1值在正常、轻、中组中存在差异(P<0.05)。结论：早期KOA患者骨量的丢失程度较非KOA人群低，其可能与KOA的发生发展抑制骨吸收有关。随KOA严重程度的增加，KOA患者骨形成能力减低。
【关键词】 膝骨关节炎； 骨质疏松； 骨密度； 骨代谢指标
The Association between Occurrence and Development of Postmenopausal Knee Osteoarthritis and Bone Mineral Density/HOU Da-biao，LUO Si-min，JIANG Xiao，et al.//Medical Innovation of China，2015，12(24)：011-013
, http://www.100md.com
【Abstract】 Objective：To explore the impact of knee osteoarthritis(KOA) in elderly women on bone mineral density(BMD) by comparing and analyzing the BMD，bone metabolic markers of the normal people and patients with various degrees of KOA in postmenopausal period.Method：166 postmenopausal women were divided into four groups，including normal group， mild group， moderate group and severe group by Lequesne Index text. All the women were examined BMD by Dual energy X-ray absorptiometry，bone metabolic markers(BAP，CTX-1).Furthermore，patients with the symptoms of KOA were also examined by X-ray on knee joint in erect position.The change of these indexes were observed in different groups.Result：Compared KOA patients in postmenopause with those in normal，the number of people whose T value was less than of equal to -1 were different in each group(P<0.05).In terms of BAP，there was significant difference in groups with KOA(P<0.05).And there was significant difference of CTX-1 in groups of normal， mild and moderate(P<0.05).Conclusion：The KOA patients in the early stage sustain less bone mass loss than those without KOA，which may be associated with KOA inhibiting bone resorption.With the increasing of KOA severity，the bone formation ability reduces.
, 百拇医药
【Key words】 Knee osteoarthritis； Osteoporosis； Bone mineral density； Bone metabolism marker
First-author’s address：The Affiliated First Hospital of Ji’nan University， Guangzhou 510630，China
doi：10.3969/j.issn.1674-4985.2015.24.004
随着人口老龄化社会的到来，膝骨性关节炎(knee osteoarthritis，KOA)和绝经后骨质疏松症(postmenopausal osteoporosis，PMO)是严重影响中老年女性生活质量的两个常见疾病。KOA与PMO两者虽各自存在不同的病因和病理变化，但他们同属与年龄相关的退行性病变[1]。目前KOA与PMO是否存在联系？KOA能否影响绝经后人群的骨密度？两者关系是近年来研究热点，但仍未达成统一共识。本文通过Lequesne指数(Lequesne index)测试得分的高低来评判绝经后女性KOA严重程度，分析和比较绝经后正常人群以及不同程度KOA患者骨密度及骨代谢指标变化规律，从而获得KOA的发生发展对绝经后人群骨密度的影响机制，明确两者关系。
1 资料与方法, http://www.100md.com(侯大标 罗斯敏 蒋笑 等)
【关键词】 膝骨关节炎； 骨质疏松； 骨密度； 骨代谢指标
The Association between Occurrence and Development of Postmenopausal Knee Osteoarthritis and Bone Mineral Density/HOU Da-biao，LUO Si-min，JIANG Xiao，et al.//Medical Innovation of China，2015，12(24)：011-013
, http://www.100md.com
【Abstract】 Objective：To explore the impact of knee osteoarthritis(KOA) in elderly women on bone mineral density(BMD) by comparing and analyzing the BMD，bone metabolic markers of the normal people and patients with various degrees of KOA in postmenopausal period.Method：166 postmenopausal women were divided into four groups，including normal group， mild group， moderate group and severe group by Lequesne Index text. All the women were examined BMD by Dual energy X-ray absorptiometry，bone metabolic markers(BAP，CTX-1).Furthermore，patients with the symptoms of KOA were also examined by X-ray on knee joint in erect position.The change of these indexes were observed in different groups.Result：Compared KOA patients in postmenopause with those in normal，the number of people whose T value was less than of equal to -1 were different in each group(P<0.05).In terms of BAP，there was significant difference in groups with KOA(P<0.05).And there was significant difference of CTX-1 in groups of normal， mild and moderate(P<0.05).Conclusion：The KOA patients in the early stage sustain less bone mass loss than those without KOA，which may be associated with KOA inhibiting bone resorption.With the increasing of KOA severity，the bone formation ability reduces.
, 百拇医药
【Key words】 Knee osteoarthritis； Osteoporosis； Bone mineral density； Bone metabolism marker
First-author’s address：The Affiliated First Hospital of Ji’nan University， Guangzhou 510630，China
doi：10.3969/j.issn.1674-4985.2015.24.004
随着人口老龄化社会的到来，膝骨性关节炎(knee osteoarthritis，KOA)和绝经后骨质疏松症(postmenopausal osteoporosis，PMO)是严重影响中老年女性生活质量的两个常见疾病。KOA与PMO两者虽各自存在不同的病因和病理变化，但他们同属与年龄相关的退行性病变[1]。目前KOA与PMO是否存在联系？KOA能否影响绝经后人群的骨密度？两者关系是近年来研究热点，但仍未达成统一共识。本文通过Lequesne指数(Lequesne index)测试得分的高低来评判绝经后女性KOA严重程度，分析和比较绝经后正常人群以及不同程度KOA患者骨密度及骨代谢指标变化规律，从而获得KOA的发生发展对绝经后人群骨密度的影响机制，明确两者关系。
1 资料与方法, http://www.100md.com(侯大标 罗斯敏 蒋笑 等)