术前序贯化放疗治疗局部晚期宫颈癌分析(1)
【摘要】 目的：分析术前使用序贯化放疗与单纯放疗治疗局部晚期宫颈癌的近期疗效。方法：选取2011年
1月-2014年3月在本院确诊的局部晚期宫颈癌患者62例作为研究对象，采用随机数字表法分为两组，序贯组34例行序贯化放疗，对照组28例行单纯术前放疗；放疗后MRI评价疗效，符合条件者放疗后2～3周行开腹宫颈癌根治术，观察比较两组治疗疗效、毒副反应及术中、术后情况。结果：序贯组的有效率及手术率均高于对照组，比较差异有统计学意义(P<0.05)。序贯组骨髓抑制及胃肠道反应发生情况多于对照组，比较差异均有统计学意义(P<0.05)；两组放射性直肠、膀胱炎症及皮肤反应发生情况比较差异无统计学性意义(P>0.05)；序贯组的手术时间、术中出血量、术后淋巴结转移及脉管癌栓情况均优于对照组，比较差异有统计学意义(P<0.05)。结论：术前序贯化放疗后手术治疗局部晚期宫颈癌近期疗效确切，安全性高，值得进一步进行相关临床研究。
【关键词】 宫颈癌； 新辅助； 化放疗
, http://www.100md.com
Analysis of Sequential Chemoradiotherapy before Operation in the Treatment of Advanced Cervical Carcinoma/LUO Qiu-yu，MEI Chang-wu，HONG Shan-er，et al.//Medical Innovation of China，2015，12(24)：044-046
【Abstract】 Objective：To analyze the recent effect of sequential neoadjuvant chemoradiotherapy and radiotherapy in the treatment of local advanced cervical carcinoma before operation.Method：62 patients who were diagnosed with local advanced cervical carcinoma in our hospital from January 2011 to March 2014 were selected and randomly divided into two groups.34 patients in the sequential group were treated by sequential neoadjuvant chemoradiotherapy.The other 28 patients in the control group were just treated by radiotherapy.The effects were evaluated by MRI after the radiotherapy .Then patients in line with the conditions of radical hysterectomy got surgery 2 to 3 weeks after the radiotherapy.The treatment effect，toxic and side effects，the situation during and after the operation of the two groups were observed and compared.Result：The effective rate and surgery rate of the sequential group were higher than those of the control group，the differences were statistically significant(P<0.05).The occurrence rates of bone marrow suppression and gastrointestinal reaction in the sequential group were higher than those in the control group，the differences were statistically significant(P<0.05).There were no statistical differences in the occurrence of redioactive rectum，bladder inflammation and skin reaction between the two groups(P>0.05).Compared with the control group，the sequential group had less operation time，less amount of bleeding，lower rate of postoperative lymph node metastasis and vessel carcinoma embolus，the differences were statistically significant(P<0.05). Conclusion：The recent effect of sequential neoadjuvant chemoradiotherapy before local advanced cervical carcinoma operation is exact.This treatment is worth further clinical studying.
【Key words】 Cervical carcinoma； Neoadjuvant； Chemoradiotherapy, http://www.100md.com(罗秋育 梅昌武 洪珊儿 等)
1月-2014年3月在本院确诊的局部晚期宫颈癌患者62例作为研究对象，采用随机数字表法分为两组，序贯组34例行序贯化放疗，对照组28例行单纯术前放疗；放疗后MRI评价疗效，符合条件者放疗后2～3周行开腹宫颈癌根治术，观察比较两组治疗疗效、毒副反应及术中、术后情况。结果：序贯组的有效率及手术率均高于对照组，比较差异有统计学意义(P<0.05)。序贯组骨髓抑制及胃肠道反应发生情况多于对照组，比较差异均有统计学意义(P<0.05)；两组放射性直肠、膀胱炎症及皮肤反应发生情况比较差异无统计学性意义(P>0.05)；序贯组的手术时间、术中出血量、术后淋巴结转移及脉管癌栓情况均优于对照组，比较差异有统计学意义(P<0.05)。结论：术前序贯化放疗后手术治疗局部晚期宫颈癌近期疗效确切，安全性高，值得进一步进行相关临床研究。
【关键词】 宫颈癌； 新辅助； 化放疗
, http://www.100md.com
Analysis of Sequential Chemoradiotherapy before Operation in the Treatment of Advanced Cervical Carcinoma/LUO Qiu-yu，MEI Chang-wu，HONG Shan-er，et al.//Medical Innovation of China，2015，12(24)：044-046
【Abstract】 Objective：To analyze the recent effect of sequential neoadjuvant chemoradiotherapy and radiotherapy in the treatment of local advanced cervical carcinoma before operation.Method：62 patients who were diagnosed with local advanced cervical carcinoma in our hospital from January 2011 to March 2014 were selected and randomly divided into two groups.34 patients in the sequential group were treated by sequential neoadjuvant chemoradiotherapy.The other 28 patients in the control group were just treated by radiotherapy.The effects were evaluated by MRI after the radiotherapy .Then patients in line with the conditions of radical hysterectomy got surgery 2 to 3 weeks after the radiotherapy.The treatment effect，toxic and side effects，the situation during and after the operation of the two groups were observed and compared.Result：The effective rate and surgery rate of the sequential group were higher than those of the control group，the differences were statistically significant(P<0.05).The occurrence rates of bone marrow suppression and gastrointestinal reaction in the sequential group were higher than those in the control group，the differences were statistically significant(P<0.05).There were no statistical differences in the occurrence of redioactive rectum，bladder inflammation and skin reaction between the two groups(P>0.05).Compared with the control group，the sequential group had less operation time，less amount of bleeding，lower rate of postoperative lymph node metastasis and vessel carcinoma embolus，the differences were statistically significant(P<0.05). Conclusion：The recent effect of sequential neoadjuvant chemoradiotherapy before local advanced cervical carcinoma operation is exact.This treatment is worth further clinical studying.
【Key words】 Cervical carcinoma； Neoadjuvant； Chemoradiotherapy, http://www.100md.com(罗秋育 梅昌武 洪珊儿 等)