中西医结合治疗对改善放射性肺纤维化患者生活质量的疗效研究(1)
【摘要】 目的：探讨中西医结合治疗对改善放射性肺纤维化(Radiation-induced pulmonary fibrosis，RPF)患者生活质量的疗效。方法：选取本院2012年6月-2013年12月收治的100例经中医辨证确诊为属气虚血瘀、痰湿内阻的RPF患者，随机分为对照组和治疗组两组，每组各50例。对照组采用常规抗感染、免疫及糖皮质激素治疗，治疗组在常规西医治疗的基础上配合中药复方化纤方治疗。根据圣乔治医院呼吸问题调查问卷(The St George’s Respiratory Questionnaire)评价疗效，分别进行治疗前评分和治疗3个月后评分。结果：两组患者呼吸症状、活动受限、疾病影响、肺功能检查比较差异均有统计学意义(P<0.05)，治疗组随访时疗效优于对照组。结论：中西医结合治疗RPF临床疗效优于单一西医治疗，可以改善RPF患者的临床症状，提高生活质量。
【关键词】 放射性肺纤维化； 中西医结合治疗； 生活质量
【Abstract】 Objective： To investigate the efficacy of combine traditional Chinese and western medicine to improve the quality of life in patients with radiation-induced pulmonary fibrosis.Method：100 radiation-induced pulmonary fibrosis(RPF) cases who were diagnosed by traditional Chinese medicine(TCM) as qi-deficiency blood stasis and phlegm resistance were collected in our hospital from June 2012 to December 2013. All the patients were randomly divided into two groups， control group and treatment group，50 cases in each group.Patients in control group were treated with conventional anti-infection，immunity and glucocorticoid therapy while treatment group was treated with TCM therapy on the base of conventional western medicine treatment. Before and followed-up three months treatment，two groups were tested according to the St George’s Respiratory Questionnaire to evaluate the efficacy.Result：Compared two groups，the difference of respiratory symptoms，activity limitation，disease impaction， and pulmonary function had statistically significant(P<0.05)， the curative effect in treatment group was better than the control group.Conclusion： The efficacy of combine traditional Chinese and Western medicine on RPF patients was superior to single Western medicine treatment， which can improve the patients’ clinical symptoms and quality of life.
, 百拇医药
【Key words】 Radiation-induced pulmonary fibrosis； Combine traditional Chinese and Western medicine； Quality of life
First-author’s address：Tumor Hospital of Tai’an，Tai’an 271000，China
doi：10.3969/j.issn.1674-4985.2015.25.033
放射性肺损伤是胸部恶性肿瘤进行放射治疗后引起的非感染性病变，发生率约为11%[1]。肺的放射性纤维化(Radiation-induced pulmonary fibrosis，RPF)是放射性肺损伤的晚期表现，约在放射治疗后60～200 d发生。进展较缓慢，呈隐匿发展，在放疗1～2年后趋于稳定。目前，本病尚无有效的治疗方法，仅限于非特异性抗炎，免疫抑制剂及糖皮质激素等，但是在临床上这些治疗方法都不能明显改善患者的生活质量或延长其生存期[2-4]。因此大多数患者具有生理和心理的双重痛苦，尤其是心理上的悲观失望情绪带来的失落感和负疚感，使其生活态度随之改变，生活质量下降。根据中医理论认为：气虚血瘀、痰湿内阻是该病的基本病机表现，临床运用中药复方化纤方配合西药治疗RPF，取得了一定成果[5-7]。现将2012年6月-2013年12月在本院行中西医结合治疗的RPF 50例患者资料进行分析，探讨中西医结合治疗对改善RPF患者生活质量的疗效。
1 资料与方法
1.1 一般资料 选择本院自2012年6月-2013年12月以来在放疗病房就诊治疗，符合诊断标准，对自己的病情知情并自愿参与调查研究的100例RPF患者作为研究对象，其中男52例，女48例，年龄48～82岁，平均(65.1±8.99)岁。将100例患者采用随机分组的方法分为两组，治疗组与对照组，每组各50例。治疗组中男27例，女23例，平均年龄(64.5±8.91)岁；对照组中男22例，女28例，平均年龄(64.6±8.82)岁，, 百拇医药(程和瑞)
【关键词】 放射性肺纤维化； 中西医结合治疗； 生活质量
【Abstract】 Objective： To investigate the efficacy of combine traditional Chinese and western medicine to improve the quality of life in patients with radiation-induced pulmonary fibrosis.Method：100 radiation-induced pulmonary fibrosis(RPF) cases who were diagnosed by traditional Chinese medicine(TCM) as qi-deficiency blood stasis and phlegm resistance were collected in our hospital from June 2012 to December 2013. All the patients were randomly divided into two groups， control group and treatment group，50 cases in each group.Patients in control group were treated with conventional anti-infection，immunity and glucocorticoid therapy while treatment group was treated with TCM therapy on the base of conventional western medicine treatment. Before and followed-up three months treatment，two groups were tested according to the St George’s Respiratory Questionnaire to evaluate the efficacy.Result：Compared two groups，the difference of respiratory symptoms，activity limitation，disease impaction， and pulmonary function had statistically significant(P<0.05)， the curative effect in treatment group was better than the control group.Conclusion： The efficacy of combine traditional Chinese and Western medicine on RPF patients was superior to single Western medicine treatment， which can improve the patients’ clinical symptoms and quality of life.
, 百拇医药
【Key words】 Radiation-induced pulmonary fibrosis； Combine traditional Chinese and Western medicine； Quality of life
First-author’s address：Tumor Hospital of Tai’an，Tai’an 271000，China
doi：10.3969/j.issn.1674-4985.2015.25.033
放射性肺损伤是胸部恶性肿瘤进行放射治疗后引起的非感染性病变，发生率约为11%[1]。肺的放射性纤维化(Radiation-induced pulmonary fibrosis，RPF)是放射性肺损伤的晚期表现，约在放射治疗后60～200 d发生。进展较缓慢，呈隐匿发展，在放疗1～2年后趋于稳定。目前，本病尚无有效的治疗方法，仅限于非特异性抗炎，免疫抑制剂及糖皮质激素等，但是在临床上这些治疗方法都不能明显改善患者的生活质量或延长其生存期[2-4]。因此大多数患者具有生理和心理的双重痛苦，尤其是心理上的悲观失望情绪带来的失落感和负疚感，使其生活态度随之改变，生活质量下降。根据中医理论认为：气虚血瘀、痰湿内阻是该病的基本病机表现，临床运用中药复方化纤方配合西药治疗RPF，取得了一定成果[5-7]。现将2012年6月-2013年12月在本院行中西医结合治疗的RPF 50例患者资料进行分析，探讨中西医结合治疗对改善RPF患者生活质量的疗效。
1 资料与方法
1.1 一般资料 选择本院自2012年6月-2013年12月以来在放疗病房就诊治疗，符合诊断标准，对自己的病情知情并自愿参与调查研究的100例RPF患者作为研究对象，其中男52例，女48例，年龄48～82岁，平均(65.1±8.99)岁。将100例患者采用随机分组的方法分为两组，治疗组与对照组，每组各50例。治疗组中男27例，女23例，平均年龄(64.5±8.91)岁；对照组中男22例，女28例，平均年龄(64.6±8.82)岁，, 百拇医药(程和瑞)