儿泻停预防肺炎抗生素相关性腹泻的临床研究(1)
【摘要】 目的：探讨儿泻停颗粒在肺炎抗生素相关性腹泻方面的预防作用。方法：选择2013年6-12月本院小儿肺炎患者230例作为研究对象，采用随机数字表法分为两组，预防组118例抗生素及对症治疗同时服用儿泻停，对照组112例进行抗生素及对症治疗，出现腹泻后加服儿泻停，比较两组腹泻发生率、严重程度、疗效、腹泻持续时间、治疗腹泻疗程及不同住院时间腹泻发生率。结果：预防组腹泻发生率及严重程度均低于对照组，疗效优于对照组，腹泻持续时间以及治疗腹泻疗程均短于对照组，不同住院时间腹泻发生率低于对照组，比较差异均有统计学意义(P<0.05)，两组均无不良反应发生。结论：儿泻停能降低肺炎抗生素相关性腹泻的发生率，早期应用可缩短腹泻持续时间和疗程，利于患儿早日康复。
【关键词】 儿泻停； 肺炎； 抗生素相关性腹泻
Clinical Research of Erxieting in the Prevention of Antibiotic-associated Diarrhea/SHI Jing-mei.//Medical Innovation of China，2015，12(26)：130-132
, http://www.100md.com
【Abstract】 Objective：To investigate the effect of Erxieting in the prevention of antibiotic-associated diarrhea.Method：230 children with pneumonia in our hospital from June 2013 to December 2013 were selected and randomly divided into two groups.118 cases in the prevention group were given Erxieting on the basis of antibiotics and symptomatic treatment.112 cases in the control group were given antibiotics and symptomatic treatment，Erxieting was given to them after the diarrhea occurred.The incidence of diarrhea and its severity，curative effect，duration of diarrhea，treatment course of diarrhea and the incidence rates in different time were compared between the two groups.Result：The incidence of diarrhea and its severity in the prevention group was lower than those in the control group，the curative effect of the prevention group was better than that of the control group，the duration and treatment course of diarrhea in the prevention group were shorter than those in the control group，the incidence rates in different time of the prevention group were lower than those of the control group，the differences above were all statistically significant(P<0.05).There were no adverse reactions in the two groups.Conclusion：Erxieting can be used to prevent antibiotic-associated diarrhea in infants，its early application can reduce the duration and treatment course of diarrhea.It is good for patients’ speedy recovery.
, 百拇医药
【Key words】 Erxieting； Pneumonia； Antibiotic-associated diarrhea
First-author’s address：The Children’s Hospital of Changzhou City Affiliated to Nantong University，Changzhou 213003，China
doi：10.3969/j.issn.1674-4985.2015.26.039
肺炎是小儿最常见的呼吸系统疾病之一。由于婴幼儿各器官功能发育未成熟机体免疫力低，容易发展为重症肺炎，是婴儿时期主要死亡原因之一[1]。而抗生素是其治疗的主要药物之一。抗生素在杀灭病原微生物的同时也抑制了正常菌群中的有益微生物，使机体内相对稳定的生态屏障被破坏，导致肠道菌群的构成及功能发生改变、失调，从而导致抗生素相关性腹泻的发生率升高。在我国，肺炎占儿科住院患者总数约24.5%～56.2%，其中婴幼儿肺炎住院数为学龄儿童的39.5倍[2]。近年来使用微生态制剂预防肺炎抗生素相关性腹泻已取得良好的效果[3-5]。本科于2013年6-12月对肺炎抗生素相关性腹泻患儿采用儿泻停辅助治疗，取得了良好的疗效，现报道如下。, 百拇医药(拾景梅)
【关键词】 儿泻停； 肺炎； 抗生素相关性腹泻
Clinical Research of Erxieting in the Prevention of Antibiotic-associated Diarrhea/SHI Jing-mei.//Medical Innovation of China，2015，12(26)：130-132
, http://www.100md.com
【Abstract】 Objective：To investigate the effect of Erxieting in the prevention of antibiotic-associated diarrhea.Method：230 children with pneumonia in our hospital from June 2013 to December 2013 were selected and randomly divided into two groups.118 cases in the prevention group were given Erxieting on the basis of antibiotics and symptomatic treatment.112 cases in the control group were given antibiotics and symptomatic treatment，Erxieting was given to them after the diarrhea occurred.The incidence of diarrhea and its severity，curative effect，duration of diarrhea，treatment course of diarrhea and the incidence rates in different time were compared between the two groups.Result：The incidence of diarrhea and its severity in the prevention group was lower than those in the control group，the curative effect of the prevention group was better than that of the control group，the duration and treatment course of diarrhea in the prevention group were shorter than those in the control group，the incidence rates in different time of the prevention group were lower than those of the control group，the differences above were all statistically significant(P<0.05).There were no adverse reactions in the two groups.Conclusion：Erxieting can be used to prevent antibiotic-associated diarrhea in infants，its early application can reduce the duration and treatment course of diarrhea.It is good for patients’ speedy recovery.
, 百拇医药
【Key words】 Erxieting； Pneumonia； Antibiotic-associated diarrhea
First-author’s address：The Children’s Hospital of Changzhou City Affiliated to Nantong University，Changzhou 213003，China
doi：10.3969/j.issn.1674-4985.2015.26.039
肺炎是小儿最常见的呼吸系统疾病之一。由于婴幼儿各器官功能发育未成熟机体免疫力低，容易发展为重症肺炎，是婴儿时期主要死亡原因之一[1]。而抗生素是其治疗的主要药物之一。抗生素在杀灭病原微生物的同时也抑制了正常菌群中的有益微生物，使机体内相对稳定的生态屏障被破坏，导致肠道菌群的构成及功能发生改变、失调，从而导致抗生素相关性腹泻的发生率升高。在我国，肺炎占儿科住院患者总数约24.5%～56.2%，其中婴幼儿肺炎住院数为学龄儿童的39.5倍[2]。近年来使用微生态制剂预防肺炎抗生素相关性腹泻已取得良好的效果[3-5]。本科于2013年6-12月对肺炎抗生素相关性腹泻患儿采用儿泻停辅助治疗，取得了良好的疗效，现报道如下。, 百拇医药(拾景梅)