黏蛋白2在结肠癌中的表达及其相关临床意义的研究(1)
【摘要】 目的：研究黏蛋白(MUC2)在结肠正常组织、结肠良性腺瘤组织和结肠癌组织中的表达状况，以及MUC2的表达情况与结肠癌患者临床资料的关联。方法：选择2011年3月-2015年3月本院手术切除的结肠正常组织15例，结肠良性腺瘤组织41例及结肠癌组织121例，应用免疫组织化学技术检测MUC2在不同组织中的表达。结果：(1)MUC2在结肠正常组织、结肠良性腺瘤组织和结肠癌组织中的阳性表达率分别为100%(15/15)、73.17%(30/41)和46.28%(56/121)，不同组织中MUC2阳性表达率比较，差异有统计学意义(P<0.01)。(2)MUC2高表达的结肠癌患者组织分型、淋巴结转移及肿瘤分期均优于MUC2低表达患者，比较差异均有统计学意义(P<0.05)。结论：结肠癌中MUC2的表达状况与组织分型、淋巴结转移和肿瘤分期有关。MUC2的表达下调可能参与了结肠癌的发生、发展、浸润和转移等过程。
【关键词】 黏蛋白2； 结肠腺瘤； 结肠癌
Research of the Expression and Its Associated Clinical Significance of MUC2 in Colorectal Carcinomas/ZUO Xiao-xu，ZHU Xi-jia，LI Sheng-guo，et al.//Medical Innovation of China，2015，12(29)：012-014
, 百拇医药
【Abstract】 Objective：To investigate the expression of MUC2 in normal colorectal tissue，colorectal adenomas and colorectal carcinomas，and to explore the relation between the expression of MUC2 and its associated clinical data.Method：15 cases of normal colorectal tissues，41 cases of colorectal adenomas tissues and 121 cases of colorectal carcinomas tissues in our hospital were selected from March 2011 to March 2015.The expression of MUC2 in different tissues were detected by immunohistochemistry.Result：(1)The positive expression rates of MUC2 in normal colorectal tissues，colorectal adenomas tissues and colorectal carcinomas tissues were 100%(15/15)，73.17%(30/41) and 46.28%(56/121) respectively.The differences of the positive expression rates in different tissues were statistically significant(P<0.01).(2)The histological differentiation，lymph node metastasis and tumor stage in patients with high expression rates of MUC2 were better than those in patients with low expression rates of MUC2，the differences were statistically significant(P<0.05).Conclusion：The expression of MUC2 in colorectal carcinomas has relationships with histological differentiation，lymph node metastasis and tumor stage.The down-regulation of MUC2 expression may play a role in the carcinogenesis，progression，infiltration，metastasis and other processes of colorectal carcinomas.
, 百拇医药
【Key words】 MUC2； Colorectal adenoma； Colorectal carcinoma
First-author’s address：The Second Affiliated Hospital of Guilin Medical University，Guilin 541000，China
doi：10.3969/j.issn.1674-4985.2015.29.004
结肠癌(colorectal cancer，CRC)是目前世界上排名第三的常见恶性肿瘤，也是肿瘤引起相关死亡的常见原因之一[1-2]。在发展中国家，结肠癌是男性排名第二、女性排名第三的肿瘤相关性疾病引起死亡的原因[3]。因此，结肠癌的早期预防、早期诊断及积极治疗等对于降低结肠癌的发病率及死亡率显得尤为重要。黏蛋白(mucins，MUC)是由胃肠道、呼吸道和卵巢等上皮组织分泌的大分子糖蛋白，有润滑和保护的作用，目前已发现有21个家族成员[4]。MUC2最早是由美国学者于1989年在人类小肠组织的cDNA表达文库中克隆到的一种黏蛋白核心肽基因，定位于人类染色体的11p 15.3～15.5[5]。MUC2是一种由MUC2基因编码的分泌型黏蛋白，MUC2基因是由可变数量的重复序列(VNTR)构成，VNTR的氨基酸排序为：PTTTPISTTTTVTPTPTPTGTQT[6]。近年来，研究发现MUC2的表达异常与结肠癌、胃癌及胰腺导管腺癌等癌症相关。本研究旨在讨论MUC2在结肠正常组织、结肠良性腺瘤组织和结肠癌中的表达情况及各自的关联，并对MUC2与结肠癌患者的临床相关资料进行研究，现具体报道如下。, 百拇医药(左晓旭 朱袭嘉 李盛国 罗喜顺 甘泽林 王海鹏)
【关键词】 黏蛋白2； 结肠腺瘤； 结肠癌
Research of the Expression and Its Associated Clinical Significance of MUC2 in Colorectal Carcinomas/ZUO Xiao-xu，ZHU Xi-jia，LI Sheng-guo，et al.//Medical Innovation of China，2015，12(29)：012-014
, 百拇医药
【Abstract】 Objective：To investigate the expression of MUC2 in normal colorectal tissue，colorectal adenomas and colorectal carcinomas，and to explore the relation between the expression of MUC2 and its associated clinical data.Method：15 cases of normal colorectal tissues，41 cases of colorectal adenomas tissues and 121 cases of colorectal carcinomas tissues in our hospital were selected from March 2011 to March 2015.The expression of MUC2 in different tissues were detected by immunohistochemistry.Result：(1)The positive expression rates of MUC2 in normal colorectal tissues，colorectal adenomas tissues and colorectal carcinomas tissues were 100%(15/15)，73.17%(30/41) and 46.28%(56/121) respectively.The differences of the positive expression rates in different tissues were statistically significant(P<0.01).(2)The histological differentiation，lymph node metastasis and tumor stage in patients with high expression rates of MUC2 were better than those in patients with low expression rates of MUC2，the differences were statistically significant(P<0.05).Conclusion：The expression of MUC2 in colorectal carcinomas has relationships with histological differentiation，lymph node metastasis and tumor stage.The down-regulation of MUC2 expression may play a role in the carcinogenesis，progression，infiltration，metastasis and other processes of colorectal carcinomas.
, 百拇医药
【Key words】 MUC2； Colorectal adenoma； Colorectal carcinoma
First-author’s address：The Second Affiliated Hospital of Guilin Medical University，Guilin 541000，China
doi：10.3969/j.issn.1674-4985.2015.29.004
结肠癌(colorectal cancer，CRC)是目前世界上排名第三的常见恶性肿瘤，也是肿瘤引起相关死亡的常见原因之一[1-2]。在发展中国家，结肠癌是男性排名第二、女性排名第三的肿瘤相关性疾病引起死亡的原因[3]。因此，结肠癌的早期预防、早期诊断及积极治疗等对于降低结肠癌的发病率及死亡率显得尤为重要。黏蛋白(mucins，MUC)是由胃肠道、呼吸道和卵巢等上皮组织分泌的大分子糖蛋白，有润滑和保护的作用，目前已发现有21个家族成员[4]。MUC2最早是由美国学者于1989年在人类小肠组织的cDNA表达文库中克隆到的一种黏蛋白核心肽基因，定位于人类染色体的11p 15.3～15.5[5]。MUC2是一种由MUC2基因编码的分泌型黏蛋白，MUC2基因是由可变数量的重复序列(VNTR)构成，VNTR的氨基酸排序为：PTTTPISTTTTVTPTPTPTGTQT[6]。近年来，研究发现MUC2的表达异常与结肠癌、胃癌及胰腺导管腺癌等癌症相关。本研究旨在讨论MUC2在结肠正常组织、结肠良性腺瘤组织和结肠癌中的表达情况及各自的关联，并对MUC2与结肠癌患者的临床相关资料进行研究，现具体报道如下。, 百拇医药(左晓旭 朱袭嘉 李盛国 罗喜顺 甘泽林 王海鹏)