阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性研究(1)
【摘要】 目的：研究阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流(LPR)的相关性。方法：选择2012年9月-2013年9月本院接诊的58例OSAHS患者作为研究对象，对患者进行整夜睡眠、咽喉pH及食管压力监测，分析OSAHS与LPR之间的联系。结果：58例患者中，共有17例LPR患者，LPR患者OSAHS严重程度与咽喉pH平均值呈负相关性(P<0.05)；LPR患者食管压力均值及食管压力最低值均低于非LPR患者，比较差异均有统计学意义(P<0.05)。AHI、AHTI、非中枢性AHTI与整夜食管压力平均值呈负相关性(P<0.05)。结论：OSAHS患者病情严重程度与夜间咽喉反流的发生密切相关，OSAHS患者夜间易出现胃食管反流，导致咽喉部pH值下降。
【关键词】 阻塞性睡眠呼吸暂停低通气综合征； 夜间咽喉反流； 相关性研究
Correlation Study of Obstructive Sleep Apnea Hypopnea Syndrome and Nocturnal Laryngopharyngeal Reflux/LIANG Guo-liang，ZHOU Zhi-sen，YANG Zhi-xue，et al.//Medical Innovation of China，2015，12(29)：027-029
, http://www.100md.com
【Abstract】 Objective：To study the correlation between obstructive sleep apnea hypopnea syndrom and throat reflux at night.Method：58 patients with OSAHS in our hospital from September 2012 to September 2013 were selected as the research objects. The situation of sleep all night，the pH of the throat and the esophagus pressure were monitored.The relationship between OSAHS and LPR was analyzed.Result：Among the 58 patients，a total of 17 patients were with LPR.In the LPR patients，the severity of OSAHS had a negative correlation with the average pH of the throat(P<0.05).The average pressure and the minimum pressure of the esophageal in patients with LPR were lower than those in patients without LPR，the differences were statistically significant(P<0.05).The AHI，AHTI and non-central AHTI had a negative correlation with the average pressure of the esophageal all night(P<0.05).Conclusion：Severity OSAHS patients is closely related to the throat reflux happened at night.OSAHS patients prone to occurring gastroesophageal reflux，which resulting in a decline in pH value of the throat.
, http://www.100md.com
【Key words】 Obstructive sleep apnea hypopnea syndrom； Nocturnal throat reflux； Correlation study
First-author’s address：Hengli Hospital of Dongguan City，Dongguan 523460，China
doi：10.3969/j.issn.1674-4985.2015.29.009
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种发病机制尚不明确，临床表现多为夜间睡眠打鼾伴呼吸暂停、白天嗜睡、带有潜在致死性的睡眠呼吸疾病[1]。过去研究人员认为，考虑到OSAHS患者吸气时胸腔与食管内负压增加，因此极易引起夜间胃食管反流(GER)的发生。夜间咽喉反流(LPR)是一种近年来引起临床广泛关注的反流性疾病，有研究人员发现，LPR的发生同样与OSAHS有密切联系，不过相关研究十分少见[2-5]。为此，本文将本院2012年9月-2013年9月接诊的58例OSAHS患者作为研究对象，对阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性进行研究，具体情况报道如下。
, http://www.100md.com
1 资料与方法
1.1 一般资料 将本院2012年9月-2013年9月接诊的58例OSAHS患者作为研究对象，所选患者在入院1周前均未服用任何抗酸药物，排除甲状腺功能低下等特殊病因引起的呼吸睡眠障碍患者。58例患者均为男性，年龄26～58岁，平均(42.0±5.4)岁；体重指数(body mass index，BMI)23.7～40.4 kg/m2，平均(31.5±3.8)kg/m2；呼吸暂停通气指数(apnea hypopnea index，AHI)5.3～103.2次/h；呼吸暂停低通气时间指数(apnea hypopnea time index，AHTI)8.4～51.2 min/h，平均(29.8±5.4)min/h；最长阻塞性呼吸暂停时间27～135 s，平均(81.0±36.5)s。, http://www.100md.com(梁国良 周志森 杨智学 黄至辉 王晓旋 朱成楼 欧兵)
【关键词】 阻塞性睡眠呼吸暂停低通气综合征； 夜间咽喉反流； 相关性研究
Correlation Study of Obstructive Sleep Apnea Hypopnea Syndrome and Nocturnal Laryngopharyngeal Reflux/LIANG Guo-liang，ZHOU Zhi-sen，YANG Zhi-xue，et al.//Medical Innovation of China，2015，12(29)：027-029
, http://www.100md.com
【Abstract】 Objective：To study the correlation between obstructive sleep apnea hypopnea syndrom and throat reflux at night.Method：58 patients with OSAHS in our hospital from September 2012 to September 2013 were selected as the research objects. The situation of sleep all night，the pH of the throat and the esophagus pressure were monitored.The relationship between OSAHS and LPR was analyzed.Result：Among the 58 patients，a total of 17 patients were with LPR.In the LPR patients，the severity of OSAHS had a negative correlation with the average pH of the throat(P<0.05).The average pressure and the minimum pressure of the esophageal in patients with LPR were lower than those in patients without LPR，the differences were statistically significant(P<0.05).The AHI，AHTI and non-central AHTI had a negative correlation with the average pressure of the esophageal all night(P<0.05).Conclusion：Severity OSAHS patients is closely related to the throat reflux happened at night.OSAHS patients prone to occurring gastroesophageal reflux，which resulting in a decline in pH value of the throat.
, http://www.100md.com
【Key words】 Obstructive sleep apnea hypopnea syndrom； Nocturnal throat reflux； Correlation study
First-author’s address：Hengli Hospital of Dongguan City，Dongguan 523460，China
doi：10.3969/j.issn.1674-4985.2015.29.009
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种发病机制尚不明确，临床表现多为夜间睡眠打鼾伴呼吸暂停、白天嗜睡、带有潜在致死性的睡眠呼吸疾病[1]。过去研究人员认为，考虑到OSAHS患者吸气时胸腔与食管内负压增加，因此极易引起夜间胃食管反流(GER)的发生。夜间咽喉反流(LPR)是一种近年来引起临床广泛关注的反流性疾病，有研究人员发现，LPR的发生同样与OSAHS有密切联系，不过相关研究十分少见[2-5]。为此，本文将本院2012年9月-2013年9月接诊的58例OSAHS患者作为研究对象，对阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性进行研究，具体情况报道如下。
, http://www.100md.com
1 资料与方法
1.1 一般资料 将本院2012年9月-2013年9月接诊的58例OSAHS患者作为研究对象，所选患者在入院1周前均未服用任何抗酸药物，排除甲状腺功能低下等特殊病因引起的呼吸睡眠障碍患者。58例患者均为男性，年龄26～58岁，平均(42.0±5.4)岁；体重指数(body mass index，BMI)23.7～40.4 kg/m2，平均(31.5±3.8)kg/m2；呼吸暂停通气指数(apnea hypopnea index，AHI)5.3～103.2次/h；呼吸暂停低通气时间指数(apnea hypopnea time index，AHTI)8.4～51.2 min/h，平均(29.8±5.4)min/h；最长阻塞性呼吸暂停时间27～135 s，平均(81.0±36.5)s。, http://www.100md.com(梁国良 周志森 杨智学 黄至辉 王晓旋 朱成楼 欧兵)