拔牙创使用人羊膜的临床研究(1)
【摘要】 目的：观察人羊膜植入临床拔牙创后对牙槽骨愈合的影响。方法：选用来本院需拔除双侧下颌第二前磨牙正畸治疗的患者20例，右侧拔牙创植入人羊膜作为试验组，左侧拔牙创作为空白对照。术后1、2、3个月拍口腔全景片，观察新骨形成情况及牙槽嵴吸收评价拔牙创愈合情况。结果：术后1周牙龈愈合及术后1、2、3个月拔牙创新骨形成量试验组优于对照组，术后1、2、3个月牙槽嵴吸收高度试验组均明显低于对照组(P<0.01)；每月牙槽嵴吸收量第1、2个月试验组均低于对照组(P<0.01)，第3个月两组无明显差异(P>0.01)。结论：临床拔牙创植入人羊膜能促进拔牙创的早期愈合，保存牙槽嵴高度。
【关键词】 拔牙创； 人羊膜； 牙槽嵴
Clinical Application of the Human Amniotic Membrane in Tooth Extraction Wound/ZHAI You-wen，WANG Wen-feng，HUANG Xiao-lin，et al.//Medical Innovation of China，2015，12(30)：032-035
, http://www.100md.com
【Abstract】 Objective：To observe the effect of human amniotic membrane planted in tooth extraction wound in the knitting of alveolar bone.Method：20 patients who need to extract the two lower second premolars because of orthodontic treatment in our department were chosen. The right side were considered as the experimental group with the human amniotic membrane implanted in tooth extraction wound， and the left as blank control group. Then the condition of knitting after tooth extraction and the absorption of alveolar bone were observed by taking oral panoramic pieces respectively in the first，second and third months，to evaluate the knitting of the tooth extraction wound. Result：The healing of the gingiva in the experimental group was better than in the control group one week after the operation.The same happened in the new bone formation in the tooth extraction wound.The height of alveolar ridge absorbed in experimental group were significantly lower than control group in the 1st， 2nd， 3rd month(P<0.01).The height of alveolar ridge absorbed each month in experimental group were also lower than those of control group both in 1st and 2nd month(P<0.01)，but two groups had no obvious difference in 3rd month(P>0.01).Conclusion：Human amnion can promote the healing of tooth extraction wound in early days and keep the height of alveolar ridge.
, 百拇医药
【Key words】 Tooth extraction wound； Human amniotic membrane； Alveolar ridge
First-author’s address：Stomatology Hospital Affiliated to Jiujiang College， Jiujiang 332000，China
doi：10.3969/j.issn.1674-4985.2015.30.011
牙齿因龋坏或者严重外伤不能保留时往往需将牙拔除，拔牙术是口腔门诊常见手术，牙拔除后拔牙创对应的局部牙槽骨发生改建，牙槽嵴出现吸收，影响后期义齿修复，常规拔牙后需3个月后行牙修复。如何减少拔牙后牙槽嵴的吸收，保存牙槽嵴，促进牙槽骨的愈合，取得理想的后期修复疗效，缩短二期修复治疗时间，已是国内外研究的一个热点。近些年来国内外报道预防牙槽嵴吸收的研究很多[1-5]，但目前仍未见牙槽骨拔牙创使用人羊膜的临床研究报道。本研究以需拔除双侧第二前磨牙正畸治疗的患者为研究对象，观察人羊膜对临床拔牙创愈合及牙槽嵴改建的作用。
1 资料与方法
1.1 一般资料 选取来本院行牙正畸治疗的患者，同时需拔除双侧下颌第二前磨牙进行矫治，口内检查所有恒牙均已萌出，并无明显口腔疾患，自愿且签署知情同意书20例，年龄16～21岁，平均18岁，男8例，女12例。研究采用的人羊膜由江西瑞济生物工程技术有限公司生产(注册产品标准号YZB/国0593-2005)。, 百拇医药(翟幼文 汪文丰 黄啸林 梁向新 王鑫)
【关键词】 拔牙创； 人羊膜； 牙槽嵴
Clinical Application of the Human Amniotic Membrane in Tooth Extraction Wound/ZHAI You-wen，WANG Wen-feng，HUANG Xiao-lin，et al.//Medical Innovation of China，2015，12(30)：032-035
, http://www.100md.com
【Abstract】 Objective：To observe the effect of human amniotic membrane planted in tooth extraction wound in the knitting of alveolar bone.Method：20 patients who need to extract the two lower second premolars because of orthodontic treatment in our department were chosen. The right side were considered as the experimental group with the human amniotic membrane implanted in tooth extraction wound， and the left as blank control group. Then the condition of knitting after tooth extraction and the absorption of alveolar bone were observed by taking oral panoramic pieces respectively in the first，second and third months，to evaluate the knitting of the tooth extraction wound. Result：The healing of the gingiva in the experimental group was better than in the control group one week after the operation.The same happened in the new bone formation in the tooth extraction wound.The height of alveolar ridge absorbed in experimental group were significantly lower than control group in the 1st， 2nd， 3rd month(P<0.01).The height of alveolar ridge absorbed each month in experimental group were also lower than those of control group both in 1st and 2nd month(P<0.01)，but two groups had no obvious difference in 3rd month(P>0.01).Conclusion：Human amnion can promote the healing of tooth extraction wound in early days and keep the height of alveolar ridge.
, 百拇医药
【Key words】 Tooth extraction wound； Human amniotic membrane； Alveolar ridge
First-author’s address：Stomatology Hospital Affiliated to Jiujiang College， Jiujiang 332000，China
doi：10.3969/j.issn.1674-4985.2015.30.011
牙齿因龋坏或者严重外伤不能保留时往往需将牙拔除，拔牙术是口腔门诊常见手术，牙拔除后拔牙创对应的局部牙槽骨发生改建，牙槽嵴出现吸收，影响后期义齿修复，常规拔牙后需3个月后行牙修复。如何减少拔牙后牙槽嵴的吸收，保存牙槽嵴，促进牙槽骨的愈合，取得理想的后期修复疗效，缩短二期修复治疗时间，已是国内外研究的一个热点。近些年来国内外报道预防牙槽嵴吸收的研究很多[1-5]，但目前仍未见牙槽骨拔牙创使用人羊膜的临床研究报道。本研究以需拔除双侧第二前磨牙正畸治疗的患者为研究对象，观察人羊膜对临床拔牙创愈合及牙槽嵴改建的作用。
1 资料与方法
1.1 一般资料 选取来本院行牙正畸治疗的患者，同时需拔除双侧下颌第二前磨牙进行矫治，口内检查所有恒牙均已萌出，并无明显口腔疾患，自愿且签署知情同意书20例，年龄16～21岁，平均18岁，男8例，女12例。研究采用的人羊膜由江西瑞济生物工程技术有限公司生产(注册产品标准号YZB/国0593-2005)。, 百拇医药(翟幼文 汪文丰 黄啸林 梁向新 王鑫)