IL—6和TNF—α在结肠癌患者血清中的测定及其意义(1)
【摘要】 目的：分析白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平与结肠癌的关系。方法：选择2013年8月-2014年5月本院收治结肠癌患者39例(结肠癌组)及同期健康体检者39例(对照组)作为研究对象，测定两组两种细胞因子术前及术后血清浓度，并比较其浓度在组内和组间的差异。结果：结肠癌组血清中TNF-α浓度明显低于对照组，而IL-6浓度则高于对照组，比较差异均有统计学意义(P<0.05)；Dukes A+B期TNF-α及IL-6浓度均低于Dukes C+D期，比较差异均有统计学意义(P<0.05)；术后TNF-α浓度高于术前，IL-6浓度低于术前，比较差异均有统计学意义(P<0.05)。结论：结肠癌患者中，IL-6与TNF-α的血清浓度与对照组比较差异显著，且与肿瘤分期有一定相关性，因此对于其灵敏度和特异度可做深入研究探讨，其有可能成为结肠癌临床诊断的重要指标。
【关键词】 白介素-6； 肿瘤坏死因子-α； 结肠癌
【Abstract】 Objective：To analyze the relationship between IL-6，TNF-α and colon cancer.Method：39 patients with colon cancer(colon cancer group) and 39 healthy examined people(control group) in our hospital from August 2013 to May 2014 were selected as the research objects.The serum concentration of the two kinds of cytokines in the two groups were determined.The concentrations of cytokines were compared between the two groups.Result：The serum level of TNF-α in the colon cancer group was lower than that in the control group and the serum level of IL-6 in the colon cancer group was higher than that in the control group，the differences were statistically significant(P<0.05).The serum levels of TNF-α and L-6 in patients of Dukes A+B stage were lower than those in patients of Dukes C+D stage，the differences were statistically significant(P<0.05).After the operation，the serum levels of TNF-α in the colon cancer group was higher than that before treatment and the serum level of IL-6 was lower than that before treatment，the differences were all statistically significant(P<0.05).Conclusion：The serum levels of IL-6 and TNF-α are significantly different in patients and healthy people.They have a potential correlation with the TNM stage of tumor.The sensitivity and specificity of them shall be researched further，they may be used as important indicators for the clinical prognosis of colon carcinoma.
, 百拇医药
【Key words】 Interleukin 6； Tumor necrosis factor-α； Colon carcinoma
First-author’s address：The Second Affiliated Hospital of Guangzhou Medical University，Guangzhou 510260，China
doi：10.3969/j.issn.1674-4985.2015.32.004
结肠癌是最常见的恶性肿瘤疾病之一，是全球癌症中导致死亡的最主要因素之一，其病死率非常高，高发于40～50岁年龄组，而且其发病原因尚不明确，与高脂肪低纤维饮食、慢性炎症性病变、结肠腺瘤、生存环境改变和遗传等因素均可能相关[1-3]。由于结肠癌发病隐匿，在早期往往无明显的临床表现可见，因此当有明显的症状出现时，大多数患者已到了中晚期，此时肿瘤往往发展迅速、易于转移，从而导致病死率高和预后差，严重危害人类健康[1-3]。因此，对肿瘤的早期发现和诊断是提高临床治疗效果和预后改善的关键。机体免疫功能低下或缺陷和局部的慢性炎症可能是肿瘤形成和发展的重要原因。在人体内，具有免疫效应和生物活性的细胞调节蛋白，统称为细胞因子。它是一类由活化的免疫细胞或间质细胞合成、分泌的具有调节细胞生长分化成熟、调节免疫应答、参与炎症反应、促进或抑制生长等功能的小分子多肽类活性分子，在免疫反应过程中对其他细胞或靶细胞起作用。细胞因子可以调节和介导免疫应答、刺激造血、参与炎症反应以及组织修复等。国内外研究显示肿瘤坏死因子-α(tumor necrosis fator-α，TNF-α)和白细胞介素-6(interleukin-6，IL-6)与多种肿瘤发生、发展密切相关[4-5]。本文旨在研究TNF-α和IL-6在结肠癌患者外周血的浓度，分析其浓度在结肠直肠癌诊断、预后中的意义，现报道如下。, 百拇医药(廖德贵 王珊 周春辉 黄世章 赖妙玲)
【关键词】 白介素-6； 肿瘤坏死因子-α； 结肠癌
【Abstract】 Objective：To analyze the relationship between IL-6，TNF-α and colon cancer.Method：39 patients with colon cancer(colon cancer group) and 39 healthy examined people(control group) in our hospital from August 2013 to May 2014 were selected as the research objects.The serum concentration of the two kinds of cytokines in the two groups were determined.The concentrations of cytokines were compared between the two groups.Result：The serum level of TNF-α in the colon cancer group was lower than that in the control group and the serum level of IL-6 in the colon cancer group was higher than that in the control group，the differences were statistically significant(P<0.05).The serum levels of TNF-α and L-6 in patients of Dukes A+B stage were lower than those in patients of Dukes C+D stage，the differences were statistically significant(P<0.05).After the operation，the serum levels of TNF-α in the colon cancer group was higher than that before treatment and the serum level of IL-6 was lower than that before treatment，the differences were all statistically significant(P<0.05).Conclusion：The serum levels of IL-6 and TNF-α are significantly different in patients and healthy people.They have a potential correlation with the TNM stage of tumor.The sensitivity and specificity of them shall be researched further，they may be used as important indicators for the clinical prognosis of colon carcinoma.
, 百拇医药
【Key words】 Interleukin 6； Tumor necrosis factor-α； Colon carcinoma
First-author’s address：The Second Affiliated Hospital of Guangzhou Medical University，Guangzhou 510260，China
doi：10.3969/j.issn.1674-4985.2015.32.004
结肠癌是最常见的恶性肿瘤疾病之一，是全球癌症中导致死亡的最主要因素之一，其病死率非常高，高发于40～50岁年龄组，而且其发病原因尚不明确，与高脂肪低纤维饮食、慢性炎症性病变、结肠腺瘤、生存环境改变和遗传等因素均可能相关[1-3]。由于结肠癌发病隐匿，在早期往往无明显的临床表现可见，因此当有明显的症状出现时，大多数患者已到了中晚期，此时肿瘤往往发展迅速、易于转移，从而导致病死率高和预后差，严重危害人类健康[1-3]。因此，对肿瘤的早期发现和诊断是提高临床治疗效果和预后改善的关键。机体免疫功能低下或缺陷和局部的慢性炎症可能是肿瘤形成和发展的重要原因。在人体内，具有免疫效应和生物活性的细胞调节蛋白，统称为细胞因子。它是一类由活化的免疫细胞或间质细胞合成、分泌的具有调节细胞生长分化成熟、调节免疫应答、参与炎症反应、促进或抑制生长等功能的小分子多肽类活性分子，在免疫反应过程中对其他细胞或靶细胞起作用。细胞因子可以调节和介导免疫应答、刺激造血、参与炎症反应以及组织修复等。国内外研究显示肿瘤坏死因子-α(tumor necrosis fator-α，TNF-α)和白细胞介素-6(interleukin-6，IL-6)与多种肿瘤发生、发展密切相关[4-5]。本文旨在研究TNF-α和IL-6在结肠癌患者外周血的浓度，分析其浓度在结肠直肠癌诊断、预后中的意义，现报道如下。, 百拇医药(廖德贵 王珊 周春辉 黄世章 赖妙玲)