慢阻肺合并肺部感染患者应用盐酸氨溴索和对症治疗的疗效观察(1)
【摘要】 目的：探讨盐酸氨溴索治疗慢性阻塞性肺疾病合并肺部感染的临床效果。方法：选取本院2011年2月-2014年2月内科收治的120例慢阻肺合并肺部感染患者作为研究对象，将其根据临床治疗方案的不同分为对照组与观察组，每组60例。对照组给予临床常规治疗，观察组在对照组的基础上给予盐酸氨溴索治疗，对比分析两组患者治疗效果、治疗前后肺部感染评分(CPIS)、急性生理学和慢性健康状况评分系统Ⅱ(APACHE Ⅱ)的评分情况、临床症状改善时间、住院时间及治疗前后酸碱度(pH)、动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)和FEV1%变化情况。结果：观察组治疗总有效率95.0%明显高于对照组的75.0%，咳嗽、咳痰、胸闷气短、肺部啰音改善时间及住院时间均明显短于对照组，差异均有统计学意义(P<0.05)；两组患者治疗前CPIS、APACHE Ⅱ评分、血气指标pH、PaCO2、PaO2、肺功能指标FEV1%比较，差异均无统计学意义(P>0.05)；治疗后，观察组的CPIS、APACHE Ⅱ评分均较治疗前降低，pH、PaCO2、PaO2及FEV1%均较治疗前改善，且以上指标与对照组比较差异均有统计学意义(P<0.05)。结论：在常规治疗的基础上加用盐酸氨溴索治疗慢阻肺合并肺部感染的疗效确切，可有效缓解患者临床症状及体征，改善肺功能，安全性高，不良反应少，可显著提高患者生存质量，其临床应用价值高。
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【关键词】 慢性阻塞性肺疾病； 肺部感染； 盐酸氨溴索； 临床效果
【Abstract】 Objective：To explore the clinical effect of Ambroxol Hydrochloride in the treatment of chronic obstructive pulmonary disease(COPD) with pulmonary infection.Method：120 COPD patients with pulmonary infection in the department of internal medicine of our hospital from February 2011 to February 2014 were selected as the research objects，they were divided into the control group and the observation group according to different clinical treatment，60 cases in each group.The control group was given routine clinical treatment，the observation group was given Ambroxol Hydrochloride treatment on the basis of the control group.The treatment effects，the scores of clinical pulmonary infection score(CPIS)，acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) before and after treatment，the clinical symptom improvement time and length of hospital stay，the pH value，arterial partial pressure of oxygen，partial pressure of carbon dioxide and the change of FEV1% before and after treatment between the two groups were compared.Result：The total effective rate of the observation group was 95.0%，which was significantly higher than 75.0% of the control group，the improvement time of cough，sputum，chest condition，pulmonary rales and length of hospital stay were significantly shorter than those of the control group，the differences were statistically significant(P<0.05).There were no statistically significant differences in the CPIS，APACHE Ⅱ score，blood gas indexes such as pH，PaCO2，PaO2，pulmonary function indexes such as FEV1% before treatment between the two groups(P>0.05).After treatment，the CPIS and APACHE Ⅱ score of the observation group were significantly lower than before treatment，the pH，PaCO2，PaO2 and FEV1% were significantly better than before treatment，the differences in above indexes were statistically significant compared with the control group(P<0.05).Conclusion：The curative effect of on the basis of conventional treatment combined with Ambroxol Hydrochloride in the treatment of COPD with pulmonary infection is good，it can effectively alleviate the patients’ clinical symptoms and signs，improve pulmonary function，with high safety，less adverse reaction，can significantly improve the quality of survival，its clinical application value is high., 百拇医药(梁旭满 黄干)
, http://www.100md.com
【关键词】 慢性阻塞性肺疾病； 肺部感染； 盐酸氨溴索； 临床效果
【Abstract】 Objective：To explore the clinical effect of Ambroxol Hydrochloride in the treatment of chronic obstructive pulmonary disease(COPD) with pulmonary infection.Method：120 COPD patients with pulmonary infection in the department of internal medicine of our hospital from February 2011 to February 2014 were selected as the research objects，they were divided into the control group and the observation group according to different clinical treatment，60 cases in each group.The control group was given routine clinical treatment，the observation group was given Ambroxol Hydrochloride treatment on the basis of the control group.The treatment effects，the scores of clinical pulmonary infection score(CPIS)，acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) before and after treatment，the clinical symptom improvement time and length of hospital stay，the pH value，arterial partial pressure of oxygen，partial pressure of carbon dioxide and the change of FEV1% before and after treatment between the two groups were compared.Result：The total effective rate of the observation group was 95.0%，which was significantly higher than 75.0% of the control group，the improvement time of cough，sputum，chest condition，pulmonary rales and length of hospital stay were significantly shorter than those of the control group，the differences were statistically significant(P<0.05).There were no statistically significant differences in the CPIS，APACHE Ⅱ score，blood gas indexes such as pH，PaCO2，PaO2，pulmonary function indexes such as FEV1% before treatment between the two groups(P>0.05).After treatment，the CPIS and APACHE Ⅱ score of the observation group were significantly lower than before treatment，the pH，PaCO2，PaO2 and FEV1% were significantly better than before treatment，the differences in above indexes were statistically significant compared with the control group(P<0.05).Conclusion：The curative effect of on the basis of conventional treatment combined with Ambroxol Hydrochloride in the treatment of COPD with pulmonary infection is good，it can effectively alleviate the patients’ clinical symptoms and signs，improve pulmonary function，with high safety，less adverse reaction，can significantly improve the quality of survival，its clinical application value is high., 百拇医药(梁旭满 黄干)