低分子肝素抗凝治疗对子痫前期产妇血清MMP—9、胱抑素C水平的影响(1)
【摘要】 目的：探讨低分子肝素抗凝治疗对子痫前期产妇血清MMP-9、胱抑素C水平(CyC)的影响。方法：选取2013年1月-2015年1月本院产科分娩的单胎子痫前期患者97例作为研究对象，采用随机数字表法将其分为两组，对照组48例采用常规治疗，观察组49例在常规治疗的基础上采用低分子肝素治疗，比较两组临床疗效，血清MMP-9、CyC水平及妊娠结局的差异。结果：观察组SBP、DBP水平明显低于对照组，终止妊娠孕周、新生儿出生体重均明显优于对照组，比较差异均有统计学意义(P<0.05)。治疗前，两组血清MMP-9、CyC水平比较差异均无统计学意义(P>0.05)；治疗后，全部患者血清MMP-9、CyC水平均明显低于治疗前，其中观察组血清MMP-9、CyC水平均明显低于对照组，比较差异均有统计学意义(P<0.05)。两组自然分娩率与剖宫产率比较差异均无统计学意义(P>0.05)；观察组妊娠合并症发生率明显低于对照组，比较差异有统计学意义(P<0.05)。结论：低分子肝素抗凝治疗可显著降低子痫前期产妇血清MMP-9、CyC水平，并显著改善妊娠结局，值得临床推广应用。
, 百拇医药
【关键词】 低分子肝素； 抗凝； 子痫前期； MMP-9； 胱抑素C
【Abstract】 Objective：To study the effect of low molecular weight heparin anticoagulation on the levels of serum MMP-9 and cystatin C(CyC) in preeclampsia maternal.Method：97 cases of preeclampsia maternal in the obstetric department of our hospital from January 2013 to January 2015 were selected as the research objects.They were divided into two groups by using the random number table method.48 cases in the control group were given conventional treatment，49 cases in the observation group were given low molecular weight heparin for treatment on the basis of the control group.The clinical curative effect，serum levels of MMP-9，CyC and pregnancy outcome were compared between the two groups.Result：The SBP and DBP levels of the observation group were significantly lower than those of the control group，the gestational age when termination of pregnancy and the birth weight of the newborns in the observation group were significantly better than those in the control group，the differences were statistically significant(P<0.05).Before treatment，the differences in the serum levels of MMP-9 and CyC between the two groups were not statistically significant(P>0.05).After treatment，all patients’ serum levels of MMP-9 and CyC were significantly lower than before treatment，the serum levels of MMP-9 and CyC in the observation group were lower than those in the control group，the differences above were all statistically significant(P<0.05).The differences in the natural birth rate and cesarean delivery rate between the two groups were not statistically significant(P>0.05).The incidence rate of pregnancy complications in the observation group was obviously lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion：Low molecular weight heparin anticoagulation can significantly reduce the serum levels of MMP-9 and CyC in preeclampsia maternal and improve the pregnancy outcome，it is worthy of clinical popularization and application., http://www.100md.com(张丽 易箐 崔霞)
, 百拇医药
【关键词】 低分子肝素； 抗凝； 子痫前期； MMP-9； 胱抑素C
【Abstract】 Objective：To study the effect of low molecular weight heparin anticoagulation on the levels of serum MMP-9 and cystatin C(CyC) in preeclampsia maternal.Method：97 cases of preeclampsia maternal in the obstetric department of our hospital from January 2013 to January 2015 were selected as the research objects.They were divided into two groups by using the random number table method.48 cases in the control group were given conventional treatment，49 cases in the observation group were given low molecular weight heparin for treatment on the basis of the control group.The clinical curative effect，serum levels of MMP-9，CyC and pregnancy outcome were compared between the two groups.Result：The SBP and DBP levels of the observation group were significantly lower than those of the control group，the gestational age when termination of pregnancy and the birth weight of the newborns in the observation group were significantly better than those in the control group，the differences were statistically significant(P<0.05).Before treatment，the differences in the serum levels of MMP-9 and CyC between the two groups were not statistically significant(P>0.05).After treatment，all patients’ serum levels of MMP-9 and CyC were significantly lower than before treatment，the serum levels of MMP-9 and CyC in the observation group were lower than those in the control group，the differences above were all statistically significant(P<0.05).The differences in the natural birth rate and cesarean delivery rate between the two groups were not statistically significant(P>0.05).The incidence rate of pregnancy complications in the observation group was obviously lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion：Low molecular weight heparin anticoagulation can significantly reduce the serum levels of MMP-9 and CyC in preeclampsia maternal and improve the pregnancy outcome，it is worthy of clinical popularization and application., http://www.100md.com(张丽 易箐 崔霞)