乳腺癌分子标志物与DCE—MRI表现之间的相关性研究(1)
【摘要】 目的：探讨乳腺癌DCE-MRI表现与分子标志物的表达的相关性。方法：选择2013年2月-2014年6月本院及广东医学院第一附属医院收治的46例乳腺癌患者的临床资料进行回顾性分析，比较分析PR、ER、HER2、Ki-67不同表达状态患者的MRI检查表现及其相应的动态增强特征。结果：ER阴性表达者的癌肿边缘光滑比例明显高于ER阳性表达者，癌灶出现小肿块比例低于ER阳性表达者，比较差异均有统计学意义(P<0.05)；PR阳性表达者癌肿边缘光滑比例低于PR阴性表达者，比较差异有统计学意义(P<0.05)；HER2低表达者癌灶出现小肿块比例高于HER2过表达者，比较差异有统计学意义(P<0.05)；Ki-67低表达者癌肿边缘光滑比例低于Ki-67过表达者，癌灶出现小肿块比例高于Ki-67过表达者，比较差异均有统计学意义(P<0.05)。结论：MRI显示的乳腺癌肿大小、癌肿边缘情况均与ER、PR、HER2、Ki-67的表达存在一定相关性。
【关键词】 乳腺癌； 分子标志物； DCE-MRI检查； 相关性
, http://www.100md.com
【Abstract】 Objective：To study the correlation of DCE-MRI performance and the expression of molecular markers in breast cancer.Method：The clinical data of 46 patients with breast cancer in our hospital and the First Affiliated Hospital of Guangdong Medical College were retrospectively analyzed.The MRI performance and its dynamic enhanced features of patients with different expression situation were analyzed and compared.Result：The proportion of patients with smooth tumor edge in patients with ER and PR negative expression were higher than those in patients with ER and PR positive expression and the proportion of patients with small masses in patients with ER negative expression was lower than that in patients with ER positive expression，the differences were statistically significant(P<0.05).The proportion of patients with small masses in patients with low expression of HER2 was higher than that in patients with over expression of HER2，the difference was statistically significant(P<0.05).The proportion of patients with smooth tumor edge in patients with low expression of Ki-67 was lower than that in patients with over expression of Ki-67，the proportion of patients with small masses in patients with low expression of Ki-67 was higher than that in patients with over expression of Ki-67，the differences were statistically significant(P<0.05).Conclusion：There is a certain correlation between the size of breast tumor，the situation of tumor edge in MRI and the expression of ER，PR，Ki-67 and HER2.
, 百拇医药
【Key words】 Breast cancer； Molecular marker； Examination of DCE-MRI； Correlation
First-author’s address：The Agricultural Reclamation Center Hospital of Guangdong Province，Zhanjiang 524002，China
doi：10.3969/j.issn.1674-4985.2015.32.016
动态增强磁共振成像(DCE-MRI)为乳腺癌临床治疗中应用较为普遍，应用效果较为理想的一种诊断方式[1]。该种诊断方式在应用过程中可更好显示肿瘤具体形态以及血流动力学相关特征。淋巴结转移情况、肿瘤体积的大小、淋巴结组织病理学性质为乳腺癌最为主要的预后判断指标[2]。本次研究主要探讨乳腺癌相关分子标志物与DCE-MRI表现的相关性，现报道如下。
1 资料与方法
1.1 一般资料 选取2013年2月-2014年6月本院收治的46例乳腺癌患者作为研究对象，所有患者均为女性。入选标准：(1)接受穿刺活检被确诊为乳腺癌；(2)接受免疫组化染色，结果可获得PR、ER、Ki-67以及HER2表达状态；(3)接受治疗前均经乳腺MR检查；(4)检查结果所得到的图像质量良好，完全符合相关诊断要求。患者年龄24～77岁，平均(48.9±2.8)岁。疾病分类：浸润性导管癌32例，原位导管癌5例，浸润性小叶癌2例，7例为其他特殊类型乳腺癌。, http://www.100md.com(谌力群 朱辉严 龙成根 许平 谢磊 李薇)
【关键词】 乳腺癌； 分子标志物； DCE-MRI检查； 相关性
, http://www.100md.com
【Abstract】 Objective：To study the correlation of DCE-MRI performance and the expression of molecular markers in breast cancer.Method：The clinical data of 46 patients with breast cancer in our hospital and the First Affiliated Hospital of Guangdong Medical College were retrospectively analyzed.The MRI performance and its dynamic enhanced features of patients with different expression situation were analyzed and compared.Result：The proportion of patients with smooth tumor edge in patients with ER and PR negative expression were higher than those in patients with ER and PR positive expression and the proportion of patients with small masses in patients with ER negative expression was lower than that in patients with ER positive expression，the differences were statistically significant(P<0.05).The proportion of patients with small masses in patients with low expression of HER2 was higher than that in patients with over expression of HER2，the difference was statistically significant(P<0.05).The proportion of patients with smooth tumor edge in patients with low expression of Ki-67 was lower than that in patients with over expression of Ki-67，the proportion of patients with small masses in patients with low expression of Ki-67 was higher than that in patients with over expression of Ki-67，the differences were statistically significant(P<0.05).Conclusion：There is a certain correlation between the size of breast tumor，the situation of tumor edge in MRI and the expression of ER，PR，Ki-67 and HER2.
, 百拇医药
【Key words】 Breast cancer； Molecular marker； Examination of DCE-MRI； Correlation
First-author’s address：The Agricultural Reclamation Center Hospital of Guangdong Province，Zhanjiang 524002，China
doi：10.3969/j.issn.1674-4985.2015.32.016
动态增强磁共振成像(DCE-MRI)为乳腺癌临床治疗中应用较为普遍，应用效果较为理想的一种诊断方式[1]。该种诊断方式在应用过程中可更好显示肿瘤具体形态以及血流动力学相关特征。淋巴结转移情况、肿瘤体积的大小、淋巴结组织病理学性质为乳腺癌最为主要的预后判断指标[2]。本次研究主要探讨乳腺癌相关分子标志物与DCE-MRI表现的相关性，现报道如下。
1 资料与方法
1.1 一般资料 选取2013年2月-2014年6月本院收治的46例乳腺癌患者作为研究对象，所有患者均为女性。入选标准：(1)接受穿刺活检被确诊为乳腺癌；(2)接受免疫组化染色，结果可获得PR、ER、Ki-67以及HER2表达状态；(3)接受治疗前均经乳腺MR检查；(4)检查结果所得到的图像质量良好，完全符合相关诊断要求。患者年龄24～77岁，平均(48.9±2.8)岁。疾病分类：浸润性导管癌32例，原位导管癌5例，浸润性小叶癌2例，7例为其他特殊类型乳腺癌。, http://www.100md.com(谌力群 朱辉严 龙成根 许平 谢磊 李薇)