大剂量丙种球蛋白静脉注射治疗急性期格林—巴利综合征的临床疗效(1)
【摘要】 目的：为了进一步提高急性期格林-巴利综合征(GBS)的治疗效果和减少各种不良事件的发生几率，探讨和研究大剂量丙种球蛋白(IvIg)在治疗过程中的应用价值和意义。方法：选取2012年1月-2015年1月来本院治疗的156例急性期格林-巴利综合征患者作为研究对象，并根据患者及家属治疗意愿将其分为观察组和对照组，每组78例。对照组患者给予常规方案(营养神经、改善微循环)进行治疗，而观察组患者则在对照组治疗的基础上采取大剂量的丙种球蛋白方案治疗，对比两组患者的临床症状(急性期持续时间、肌力提升1级的平均时间、症状改善时间)，日常生活能力评分及临床疗效。结果：观察组的急性期持续时间、肌力提升1级的平均时间及症状改善时间均明显短于对照组，差异均有统计学意义(P<0.05)。两组患者治疗后Barthel指数评分均明显高于治疗前，且观察组的Barthel指数评分明显高于对照组，差异均有统计学意义(P<0.05)。经治疗后，观察组的治疗总有效率100%明显高于对照组的88.46%，差异有统计学意义(P<0.05)。结论：在治疗急性期格林-巴利综合征时选取应用大剂量的丙种球蛋白进行治疗，除了能提高治疗效果外还有利于患者生活能力的改善，效果显著，值得临床推广和应用。
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【关键词】 格林-巴利综合征； 急性期； 丙种球蛋白； 治疗
【Abstract】 Objective：To further improve the therapeutic effect of acute Guillain-Barre snydrome(GBS) and reduce the probability of adverse events，to investigate and research the value and significance of large dose gamma globulin(IvIg) in the treatment of acute Guillain-Barre snydrome.Method：156 patients with acute Guillain-Barre snydrome who were treated in our hospital from January 2012 to January 2015 were selected as the research objects，they were divided into the observation group and the control group according to the treatment intention of patients and family，78 cases in each group.The control group was given conventional treatment scheme(nutrition nerve，improve microcirculation)，while the observation group was given large dose of gamma globulin for treatment on the basis of the control group.The clinical symptoms(acute period continuous time，the average time of muscle strength increased by grade 1，symptoms improved time)，daily life ability score and curative effect between the two groups were compared.Result：The acute period continuous time，average time of muscle strength increased by grade 1 and symptom improvement time in the observation group were significantly shorter than those in the control group，the differences were statistically significant(P<0.05).The Barthel index score of the two groups after treatment were significantly higher than before treatment，and that of the observation group was significantly higher than the control group，the differences were statistically significant(P<0.05).After treatment，the total effective rate of the observation group (100%) was significantly higher than 88.46% of the control group，the difference was statistically significant(P<0.05).Conclusion：Large dose of gamma globulin in the treatment of acute Guillain-Barre syndrome，not only can improve the treatment effect，but also conducive to the improvement of patients’ living ability，the effect is significant，worthy of clinical popularization and application., 百拇医药(耿娜 张金彪 仲伟斌 丛燕楠 刘潇潇 董礼全)
, http://www.100md.com
【关键词】 格林-巴利综合征； 急性期； 丙种球蛋白； 治疗
【Abstract】 Objective：To further improve the therapeutic effect of acute Guillain-Barre snydrome(GBS) and reduce the probability of adverse events，to investigate and research the value and significance of large dose gamma globulin(IvIg) in the treatment of acute Guillain-Barre snydrome.Method：156 patients with acute Guillain-Barre snydrome who were treated in our hospital from January 2012 to January 2015 were selected as the research objects，they were divided into the observation group and the control group according to the treatment intention of patients and family，78 cases in each group.The control group was given conventional treatment scheme(nutrition nerve，improve microcirculation)，while the observation group was given large dose of gamma globulin for treatment on the basis of the control group.The clinical symptoms(acute period continuous time，the average time of muscle strength increased by grade 1，symptoms improved time)，daily life ability score and curative effect between the two groups were compared.Result：The acute period continuous time，average time of muscle strength increased by grade 1 and symptom improvement time in the observation group were significantly shorter than those in the control group，the differences were statistically significant(P<0.05).The Barthel index score of the two groups after treatment were significantly higher than before treatment，and that of the observation group was significantly higher than the control group，the differences were statistically significant(P<0.05).After treatment，the total effective rate of the observation group (100%) was significantly higher than 88.46% of the control group，the difference was statistically significant(P<0.05).Conclusion：Large dose of gamma globulin in the treatment of acute Guillain-Barre syndrome，not only can improve the treatment effect，but also conducive to the improvement of patients’ living ability，the effect is significant，worthy of clinical popularization and application., 百拇医药(耿娜 张金彪 仲伟斌 丛燕楠 刘潇潇 董礼全)