宫颈癌前哨淋巴结的临床研究(1)
【摘要】 目的：探讨亚甲蓝用于检测前哨淋巴结预测宫颈癌盆腔淋巴结转移的可行性和临床意义。方法：选择本院2010年1月-2014年1月收治的40例Ⅰb～Ⅱb期宫颈癌患者作为研究对象，对40例患者术前注射亚甲蓝示踪剂，注射后等待90～180 min后行盆腔淋巴结清扫术以及广泛子宫切除术，在术中把蓝染的淋巴结认定为前哨淋巴结，把所有蓝染的以及未蓝染的切除后的淋巴结分开送检，并分析病理结果。结果：40例宫颈癌患者中，使用亚甲蓝试剂成功定位出37例患者的前哨淋巴结，检出率为92.5%。全部40例患者均经病理确诊存在盆腔淋巴结转移，前哨淋巴结阳性11例。蓝染前哨淋巴结对于盆腔淋巴结转移预测率为92.5%，假阴性发现率为0。结论：使用亚甲蓝作为示踪剂检测前哨淋巴结是可行的，可以非常准确的识别以及定位前哨淋巴结的位置，判断是否出现盆腔内淋巴结转移，具有一定的临床价值。
【关键词】 亚甲蓝； 前哨淋巴结； 宫颈癌
Clinical Research of Sentinel Lymph Node in Cervical Cancer/CHEN Li-zhen，LIN Li-ping.//Medical Innovation of China，2015，12(34)：137-139
, 百拇医药
【Abstract】 Objective：To explore the feasibility and clinical effect of methylene blue used in the detection of sentinel lymph node which used to forecast pelvic lymphonode metastasis of cervical cancer.Method：40 patients with cervical cancer of stage Ⅰb to Ⅱb in our hospital from January 2010 and January 2014 were selected as the research objects.The injection of methylene blue were given to the 40 patients before operation，after waiting 90 to 180 minutes，they were given pelvic lymphadenectomy and radical hysterectomy.During the operation，the blue dyed lymph gland was regarded as the sentinel lymph node，then the blue dyed and un-blue dyed lymph glands which were removed from the operation were tested respectively.Then the pathology result was analyzed.Result：Among the 40 cervical cancer patients，37 patients were successfully detected with sentinel lymph nodes by methylene blue.The detection rate was 92.5%.According to the pathology result，all patients were with pelvic lymphonode metastasis and 11 patients with sentinel lymph node positive.The prediction rate of blue dyed sentinel lymph node to the pelvic lymphonode metastasis was 92.5%.The discovery rate of false negative was 0.Conclusion：It's feasible to apply methylene blue as tracer to test the sentinel lymph node.The use of methylene blue can identify and locate the position of sentinel lymph node quite accurately.Besides，the use of it can also estimate whether lymph gland shift or not，which is of great clinical value.
, 百拇医药
【Key words】 Methylene blue； Sentinel lymph node； Cervical cancer
First-author’s address：The First People’s Hospital of Jingdezhen City，Jingdezhen 333000，China
doi：10.3969/j.issn.1674-4985.2015.34.046
宫颈癌是目前世界上较为常见的妇科病恶性肿瘤，其危害了广大妇女的身心健康，宫颈癌的发病率越来越高，发病年龄越来越趋于年轻化。目前，全世界宫颈癌每年新发现的病例大概有50余万，其中85%的宫颈癌患者都集中在发展中国家[1]。而在我国宫颈癌每年新发现的病例大概有13余万[2]。盆腔淋巴结的转移是影响宫颈癌预后和手术后治疗的一个重要点，也是决定手术范围和术后辅助治疗的重要依据。笔者从2010年1月开始开展宫颈癌的术前染色法定位前哨淋巴结的研究。示踪剂的选择主要采用亚甲蓝，主要检测的是宫颈癌前哨淋巴结，主要是通过术后病理来判断盆腔淋巴结是否转移，并且通过免疫组化以及病理切片来检测宫颈癌前哨淋巴结，通过两种方式来提高宫颈癌淋巴结转移的检出率，现将具体报告如下。, http://www.100md.com(陈丽珍 林莉萍)
【关键词】 亚甲蓝； 前哨淋巴结； 宫颈癌
Clinical Research of Sentinel Lymph Node in Cervical Cancer/CHEN Li-zhen，LIN Li-ping.//Medical Innovation of China，2015，12(34)：137-139
, 百拇医药
【Abstract】 Objective：To explore the feasibility and clinical effect of methylene blue used in the detection of sentinel lymph node which used to forecast pelvic lymphonode metastasis of cervical cancer.Method：40 patients with cervical cancer of stage Ⅰb to Ⅱb in our hospital from January 2010 and January 2014 were selected as the research objects.The injection of methylene blue were given to the 40 patients before operation，after waiting 90 to 180 minutes，they were given pelvic lymphadenectomy and radical hysterectomy.During the operation，the blue dyed lymph gland was regarded as the sentinel lymph node，then the blue dyed and un-blue dyed lymph glands which were removed from the operation were tested respectively.Then the pathology result was analyzed.Result：Among the 40 cervical cancer patients，37 patients were successfully detected with sentinel lymph nodes by methylene blue.The detection rate was 92.5%.According to the pathology result，all patients were with pelvic lymphonode metastasis and 11 patients with sentinel lymph node positive.The prediction rate of blue dyed sentinel lymph node to the pelvic lymphonode metastasis was 92.5%.The discovery rate of false negative was 0.Conclusion：It's feasible to apply methylene blue as tracer to test the sentinel lymph node.The use of methylene blue can identify and locate the position of sentinel lymph node quite accurately.Besides，the use of it can also estimate whether lymph gland shift or not，which is of great clinical value.
, 百拇医药
【Key words】 Methylene blue； Sentinel lymph node； Cervical cancer
First-author’s address：The First People’s Hospital of Jingdezhen City，Jingdezhen 333000，China
doi：10.3969/j.issn.1674-4985.2015.34.046
宫颈癌是目前世界上较为常见的妇科病恶性肿瘤，其危害了广大妇女的身心健康，宫颈癌的发病率越来越高，发病年龄越来越趋于年轻化。目前，全世界宫颈癌每年新发现的病例大概有50余万，其中85%的宫颈癌患者都集中在发展中国家[1]。而在我国宫颈癌每年新发现的病例大概有13余万[2]。盆腔淋巴结的转移是影响宫颈癌预后和手术后治疗的一个重要点，也是决定手术范围和术后辅助治疗的重要依据。笔者从2010年1月开始开展宫颈癌的术前染色法定位前哨淋巴结的研究。示踪剂的选择主要采用亚甲蓝，主要检测的是宫颈癌前哨淋巴结，主要是通过术后病理来判断盆腔淋巴结是否转移，并且通过免疫组化以及病理切片来检测宫颈癌前哨淋巴结，通过两种方式来提高宫颈癌淋巴结转移的检出率，现将具体报告如下。, http://www.100md.com(陈丽珍 林莉萍)