青中年脑梗死与颈动脉不稳定斑块、D—二聚体、Hcy相关因素分析(1)
【摘要】 目的：分析脑梗死患者与颈动脉不稳定斑块、D-二聚体、同型半胱氨酸(homocysteine，Hcy)的相互关系。方法：选取2012年2月-2014年2月在本院住院的60例青中年脑梗死患者作为试验组，同时在同时期住院的高血压患者中选取无脑梗死症状的60例作为对照组。两组患者分别检测颈动脉彩超，查血清D-二聚体及Hcy水平，并对此进行比较。结果：试验组的颈动脉IMT严重程度、斑块硬化程度及颈动脉狭窄程度均明显大于对照组，差异均有统计学意义(P<0.05)。试验组患者的血清D-二聚体、Hcy水平均明显高于对照组，差异均有统计学意义(P<0.05)。结论：颈动脉不稳定斑块、D-二聚体、Hcy是急性脑梗死发生的重要危险因素，颈动脉不稳定斑块、D-二聚体、Hcy联合检测有助于预测脑梗死的发生。
【关键词】 脑梗死； 颈动脉不稳定斑块； D-二聚体； 同型半胱氨酸
【Abstract】 Objective：To analyze the relationship of cerebral infarction patients with carotid unstable plaque，serum D-dimer and Hcy levels.Method：60 young and middle-aged patients with cerebral infraction admitted to our hospital from February 2012 to February 2014 were selected as the experimental group，60 patients without symptoms of cerebral infarction who selected from patients with hypertension in the same period were regarded as the control group.They were detected by carotid artery color Doppler ultrasound，the serum levels of D-dimer and Hcy were tested，and compared all indexes.Result：The carotid IMT severity，pplaque hardening degree and carotid stenosis degree of the experimental group were significantly larger than those of the control group，the differences were statistically significant(P<0.05).The serum D-dimer and Hcy levels of the experimental group were statistically higher than those of the control group，the differences were statistically significant(P<0.05).Conclusion：The carotid unstable plaque，serum D-dimer and Hcy are the important risk factors of acute cerebral infarction，carotid unstable plaque with the serum level of D-dimer and Hcy are helpful for the early prediction of occurrence of cerebral infraction.
, http://www.100md.com
【Key words】 Cerebral infraction； Carotid unstable plaque； D-dimer； Hcy
First-author’s address：The Fifth People’s Hospital of Jiaozuo City，Jiaozuo 454002，China
doi：10.3969/j.issn.1674-4985.2015.35.020
在临床工作中，急性脑梗死占整个脑血管病患者的80%以上，病残率较高，近些年来发现青中年人的发病率逐渐增加，脑梗死会对本人、单位及社会带来危害及不利影响，其有效的治疗及预防显得尤为重要[1]。颈动脉不稳定斑块、D-二聚体、同型半胱氨酸是脑血管病的可改变的危险因素，并与脑血管病发生和/或进展密切相关，越来越受到临床重视[2]。为更好地分析青中年脑梗死患者与颈动脉不稳定斑块、D-二聚体、同型半胱氨酸(homocysteine，Hcy)的相互关系，特结合文献资料回顾性分析本院收治的120例患者的临床资料，并予以分析讨论，现报告如下。
, 百拇医药
1 资料与方法
1.1 一般资料 选取2012年2月-2014年2月在本院住院的脑血管病患者作为研究对象，550例患者中符合条件60例作为试验组，其中男38例，女22例，年龄38～64岁，平均(49.3±2.2)岁，病程1 h～3 d。入组患者符合1995年全国脑血管病学术会议通过的脑卒中诊断标准[3]，且经头颅CT及MRI证实；在同时期住院的高血压患者中选取无脑梗死症状的60例作为对照组，其中男36例，女24例，年龄36～63岁，平均(48.5±3.1)岁。排除其他疾病如感染性疾病、发热、心肝肾病变及血液病等，2周内无用药史如阿司匹林、氯吡格雷、双嘧达莫及低分子肝素等可能影响血小板功能者。两组患者的一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, 百拇医药(黄华 赵虹)
【关键词】 脑梗死； 颈动脉不稳定斑块； D-二聚体； 同型半胱氨酸
【Abstract】 Objective：To analyze the relationship of cerebral infarction patients with carotid unstable plaque，serum D-dimer and Hcy levels.Method：60 young and middle-aged patients with cerebral infraction admitted to our hospital from February 2012 to February 2014 were selected as the experimental group，60 patients without symptoms of cerebral infarction who selected from patients with hypertension in the same period were regarded as the control group.They were detected by carotid artery color Doppler ultrasound，the serum levels of D-dimer and Hcy were tested，and compared all indexes.Result：The carotid IMT severity，pplaque hardening degree and carotid stenosis degree of the experimental group were significantly larger than those of the control group，the differences were statistically significant(P<0.05).The serum D-dimer and Hcy levels of the experimental group were statistically higher than those of the control group，the differences were statistically significant(P<0.05).Conclusion：The carotid unstable plaque，serum D-dimer and Hcy are the important risk factors of acute cerebral infarction，carotid unstable plaque with the serum level of D-dimer and Hcy are helpful for the early prediction of occurrence of cerebral infraction.
, http://www.100md.com
【Key words】 Cerebral infraction； Carotid unstable plaque； D-dimer； Hcy
First-author’s address：The Fifth People’s Hospital of Jiaozuo City，Jiaozuo 454002，China
doi：10.3969/j.issn.1674-4985.2015.35.020
在临床工作中，急性脑梗死占整个脑血管病患者的80%以上，病残率较高，近些年来发现青中年人的发病率逐渐增加，脑梗死会对本人、单位及社会带来危害及不利影响，其有效的治疗及预防显得尤为重要[1]。颈动脉不稳定斑块、D-二聚体、同型半胱氨酸是脑血管病的可改变的危险因素，并与脑血管病发生和/或进展密切相关，越来越受到临床重视[2]。为更好地分析青中年脑梗死患者与颈动脉不稳定斑块、D-二聚体、同型半胱氨酸(homocysteine，Hcy)的相互关系，特结合文献资料回顾性分析本院收治的120例患者的临床资料，并予以分析讨论，现报告如下。
, 百拇医药
1 资料与方法
1.1 一般资料 选取2012年2月-2014年2月在本院住院的脑血管病患者作为研究对象，550例患者中符合条件60例作为试验组，其中男38例，女22例，年龄38～64岁，平均(49.3±2.2)岁，病程1 h～3 d。入组患者符合1995年全国脑血管病学术会议通过的脑卒中诊断标准[3]，且经头颅CT及MRI证实；在同时期住院的高血压患者中选取无脑梗死症状的60例作为对照组，其中男36例，女24例，年龄36～63岁，平均(48.5±3.1)岁。排除其他疾病如感染性疾病、发热、心肝肾病变及血液病等，2周内无用药史如阿司匹林、氯吡格雷、双嘧达莫及低分子肝素等可能影响血小板功能者。两组患者的一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, 百拇医药(黄华 赵虹)