坎地沙坦联合苯磺酸氨氯地平对老年高血压患者的临床疗效分析(1)
【摘要】 目的：探讨坎地沙坦联合苯磺酸氨氯地平治疗老年高血压患者的临床疗效。方法：选取2014年
6月-2015年5月于本院就诊并确诊为高血压的老年患者76例，随机分为两组，对照组40例采用苯磺酸氨氯地平治疗，观察组36例在对照组基础上联合坎地沙坦治疗。观察两组患者血压(收缩压及舒张压)、生活质量的改善情况；比较两组患者临床血压控制率及不良反应情况。结果：两组患者血压水平、生活质量均有所改善，但观察组改善更显著，临床血压控制率更高，差异均统计学意义(P<0.05)。两组患者均未发现不良反应。结论：坎地沙坦联合苯磺酸氨氯地平对老年高血压患疗效显著，较单用苯磺酸氨氯地平而言可更好地改善血压水平及生活质量，值得推广。
【关键词】 坎地沙坦； 苯磺酸氨氯地平； 老年高血压； 临床疗效
Clinical Curative Effect Analysis of Candesartan in Combination with Amlodipine Besylate on Elderly Patients with Hypertension/XIE Zhi-hong， LUO Jun， LI Wen-feng.//Medical Innovation of China，2015，12(36)：051-053
【Abstract】 Objective： To investigate the clinical effect of Candesartan combined with Amlodipine besylate in treatment of elderly patients with hypertension. Method： 76 elderly patients with hypertension in our hospital from June 2014 to May 2015 were selected， and they were randomly divided into two groups， 40 cases in the control group were treated with Amlodipine besylate， 36 cases in the observation group were combined with Candesartan therapy. Blood pressure (systolic blood pressure and diastolic blood pressure) and the improvement of life quality of the two groups were observed. The clinical blood pressure control rate and adverse reaction of the two groups were compared. Result： The blood pressure level and quality of life of the two groups were improved， but the observation group improved more significantly， the clinical control rate was higher， the differences were statistically significant (P<0.05)， no adverse reactions were found. Conclusion： Candesartan combined Amlodipine besylate in elderly hypertensive patients suffering from significant curative effect， compared with Amlodipine besylate， can better improve the blood pressure level and the quality of life， worthy of promotion.
【Key words】 Candesartan； Amlodipine besylate； Elderly hypertension； Clinical efficacy
First-author’s address：The People’s Hospital of Ganzhou， Ganzhou 341000，China
doi：10.3969/j.issn.1674-4985.2015.36.017
高血压是临床上一种以血压升高为主要表现的疾病，多以收缩压升高为主，疾病日久可出现心肌肥厚、血管粥样硬化等并发症[1-3]。笔者采用坎地沙坦联合苯磺酸氨氯地平进行治疗，疗效显著，且目前相关文献报道较少，在此汇报成果。
1 资料与方法
1.1 一般资料 选取2014年6月-2015年5月于本院确诊为原发性高血压的老年患者76例，诊断标准分级标准参照中国高血压防治指南修订委员会修订的《中国高血压防治指南 2010》[4]。采用随机数字表法将患者分为两组，对照组40例，男25例，女15例，平均年龄(65.65±9.55)岁，平均病程(12.26±4.03)年，伴糖尿病者13例，肥胖者15例，脑血管疾病者12例。高血压分级：1级16例，2级24例。观察组36例，男22例，女14例，平均年龄(65.86±9.43)岁，平均病程(12.57±4.14)年，伴糖尿病者12例，肥胖者15例，脑血管疾病者9例。高血压分级：1级15例，2级21例。两组患者的年龄、性别、伴发疾病及高血压分级等一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(谢志红 罗骏 李文峰)
6月-2015年5月于本院就诊并确诊为高血压的老年患者76例，随机分为两组，对照组40例采用苯磺酸氨氯地平治疗，观察组36例在对照组基础上联合坎地沙坦治疗。观察两组患者血压(收缩压及舒张压)、生活质量的改善情况；比较两组患者临床血压控制率及不良反应情况。结果：两组患者血压水平、生活质量均有所改善，但观察组改善更显著，临床血压控制率更高，差异均统计学意义(P<0.05)。两组患者均未发现不良反应。结论：坎地沙坦联合苯磺酸氨氯地平对老年高血压患疗效显著，较单用苯磺酸氨氯地平而言可更好地改善血压水平及生活质量，值得推广。
【关键词】 坎地沙坦； 苯磺酸氨氯地平； 老年高血压； 临床疗效
Clinical Curative Effect Analysis of Candesartan in Combination with Amlodipine Besylate on Elderly Patients with Hypertension/XIE Zhi-hong， LUO Jun， LI Wen-feng.//Medical Innovation of China，2015，12(36)：051-053
【Abstract】 Objective： To investigate the clinical effect of Candesartan combined with Amlodipine besylate in treatment of elderly patients with hypertension. Method： 76 elderly patients with hypertension in our hospital from June 2014 to May 2015 were selected， and they were randomly divided into two groups， 40 cases in the control group were treated with Amlodipine besylate， 36 cases in the observation group were combined with Candesartan therapy. Blood pressure (systolic blood pressure and diastolic blood pressure) and the improvement of life quality of the two groups were observed. The clinical blood pressure control rate and adverse reaction of the two groups were compared. Result： The blood pressure level and quality of life of the two groups were improved， but the observation group improved more significantly， the clinical control rate was higher， the differences were statistically significant (P<0.05)， no adverse reactions were found. Conclusion： Candesartan combined Amlodipine besylate in elderly hypertensive patients suffering from significant curative effect， compared with Amlodipine besylate， can better improve the blood pressure level and the quality of life， worthy of promotion.
【Key words】 Candesartan； Amlodipine besylate； Elderly hypertension； Clinical efficacy
First-author’s address：The People’s Hospital of Ganzhou， Ganzhou 341000，China
doi：10.3969/j.issn.1674-4985.2015.36.017
高血压是临床上一种以血压升高为主要表现的疾病，多以收缩压升高为主，疾病日久可出现心肌肥厚、血管粥样硬化等并发症[1-3]。笔者采用坎地沙坦联合苯磺酸氨氯地平进行治疗，疗效显著，且目前相关文献报道较少，在此汇报成果。
1 资料与方法
1.1 一般资料 选取2014年6月-2015年5月于本院确诊为原发性高血压的老年患者76例，诊断标准分级标准参照中国高血压防治指南修订委员会修订的《中国高血压防治指南 2010》[4]。采用随机数字表法将患者分为两组，对照组40例，男25例，女15例，平均年龄(65.65±9.55)岁，平均病程(12.26±4.03)年，伴糖尿病者13例，肥胖者15例，脑血管疾病者12例。高血压分级：1级16例，2级24例。观察组36例，男22例，女14例，平均年龄(65.86±9.43)岁，平均病程(12.57±4.14)年，伴糖尿病者12例，肥胖者15例，脑血管疾病者9例。高血压分级：1级15例，2级21例。两组患者的年龄、性别、伴发疾病及高血压分级等一般资料比较差异均无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(谢志红 罗骏 李文峰)