血管紧张素转化酶2—血管紧张素(1—7)—Mas轴在心血管和神经系统的作用(5)
[28] Jiang T，Yu J T，Zhu X C，et al.Angiotensin-(1-7) induces cerebral ischemic tolerance by promoting brain angiogenesis in a Mas/eNOS-dependent pathway[J].Br J Pharmacol，2014，171(18)：4222-4232.
[29] Rentzsch B，Todiras M，Iliescu R，et al.Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function[J]. Hypertension ，2008，52(5)：967-973.
[30] Fraga-Silva R A，Costa-Fraga F P，Murca T M，et al. Angiotensin-converting enzyme 2 activation improves endothelial function[J].Hypertension，2013，61(6)：1233-1238.
, 百拇医药
[31] Deliu E，Brailoiu G C，Eguchi S，et al.Direct evidence of intracrine angiotensin Ⅱ signaling in neurons[J].Am J Physiol Cell Physiol，2014，306(8)：C736–C744.
[32] Lanz T V，Ding Z，Ho P P，et al.Angiotensin Ⅱ sustains brain inflammation in mice via TGF-beta[J].J Clin Invest，2010，120(8)：2782-2794.
[33] Kostenis E，Milligan G，Christopoulos A，et al.G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin Ⅱ type 1 receptor[J].Circulation，2005，111(14)：1806-1813.
, 百拇医药
[34] Kuriakose S，Uzonna J E.Diminazene aceturate (Berenil)，a new use for an old compound？[J].Int Immunopharmacol，2014，21(2)：342-345.
[35] Koka V，Huang X R，Chung A C，et al.Angiotensin Ⅱ up-regulates angiotensinⅠ-converting enzyme(ACE)，but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway[J].Am J Pathol，2008，172(5)：1174-1183.
[36] Mecca A P，Regenhardt R W，O’Connor T E，et al.Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke[J].Experimental Physiology，2011，96(10)：1084-1096.
, 百拇医药
[37] AbdAlla S，Lother H，Abdel-tawab A M，et al.The angiotensin Ⅱ AT2 receptor is an AT1 receptor antagonist[J].J Biol Chem，2001，276(43)：39 721-39 726.
[38] Kostenis E，Milligan G，Christopoulos A，et al.G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin Ⅱ type 1 receptor[J].Circulation，2005，111(14)：1806-1813.
[39] Ohshima K，Mogi M，Nakaoka H，et al.Possible role of angiotensin-converting enzyme 2 and activation of angiotensin Ⅱ type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin Ⅱ type 1 receptor blockade[J].Hypertension，2014，63(3)：e53-e59.
[40] Gembardt F，van Veghel R，Coffman T M，et al.Hemodynamic effects of vasorelaxant compounds in mice lacking one，two or all three angiotensin Ⅱ receptors[J].Hypertens Res，2012，35(5)：547-551.
(收稿日期：2015-10-08) (本文编辑：王利), 百拇医药(王晶晶 梁广彬 邓凡 卢悦 张良清)
[29] Rentzsch B，Todiras M，Iliescu R，et al.Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function[J]. Hypertension ，2008，52(5)：967-973.
[30] Fraga-Silva R A，Costa-Fraga F P，Murca T M，et al. Angiotensin-converting enzyme 2 activation improves endothelial function[J].Hypertension，2013，61(6)：1233-1238.
, 百拇医药
[31] Deliu E，Brailoiu G C，Eguchi S，et al.Direct evidence of intracrine angiotensin Ⅱ signaling in neurons[J].Am J Physiol Cell Physiol，2014，306(8)：C736–C744.
[32] Lanz T V，Ding Z，Ho P P，et al.Angiotensin Ⅱ sustains brain inflammation in mice via TGF-beta[J].J Clin Invest，2010，120(8)：2782-2794.
[33] Kostenis E，Milligan G，Christopoulos A，et al.G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin Ⅱ type 1 receptor[J].Circulation，2005，111(14)：1806-1813.
, 百拇医药
[34] Kuriakose S，Uzonna J E.Diminazene aceturate (Berenil)，a new use for an old compound？[J].Int Immunopharmacol，2014，21(2)：342-345.
[35] Koka V，Huang X R，Chung A C，et al.Angiotensin Ⅱ up-regulates angiotensinⅠ-converting enzyme(ACE)，but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway[J].Am J Pathol，2008，172(5)：1174-1183.
[36] Mecca A P，Regenhardt R W，O’Connor T E，et al.Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke[J].Experimental Physiology，2011，96(10)：1084-1096.
, 百拇医药
[37] AbdAlla S，Lother H，Abdel-tawab A M，et al.The angiotensin Ⅱ AT2 receptor is an AT1 receptor antagonist[J].J Biol Chem，2001，276(43)：39 721-39 726.
[38] Kostenis E，Milligan G，Christopoulos A，et al.G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin Ⅱ type 1 receptor[J].Circulation，2005，111(14)：1806-1813.
[39] Ohshima K，Mogi M，Nakaoka H，et al.Possible role of angiotensin-converting enzyme 2 and activation of angiotensin Ⅱ type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin Ⅱ type 1 receptor blockade[J].Hypertension，2014，63(3)：e53-e59.
[40] Gembardt F，van Veghel R，Coffman T M，et al.Hemodynamic effects of vasorelaxant compounds in mice lacking one，two or all three angiotensin Ⅱ receptors[J].Hypertens Res，2012，35(5)：547-551.
(收稿日期：2015-10-08) (本文编辑：王利), 百拇医药(王晶晶 梁广彬 邓凡 卢悦 张良清)