脑白质疏松症及相关认知障碍的研究进展(3)
综上所述，LA远不是一个偶然无害的老龄化的结果，仍需要更进一步的研究来完善对它的认识，并且在临床工作中如何能够提高广大患者重视并做好预防措施，依然任重而道远。
参考文献
[1] Hachinski V C， Potter P， Merskey H. Leuko-araiosis[J]. Arch Neurol， 1987，44(1)：21-23.
[2] Auriel E， Bornstien N M， Berenyi E， et al. Clinical， radiological and pathological correlates of leukoaraiosis[J]. Acta Neurol Scand， 2011， 123 (1)：41-47.
[3] Mascalchi M， Ginestroni A， Toschi N. et al. The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and Leuko-Araiosis. A DTI and FMRI study[J]. Hum Brain Mapp， 2014，35(3)：819-830.
, 百拇医药
[4] Lin Q， Huang W Q， Tzeng C M. Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology[J]. Rev Neurosci， 2015， 26(3)： 343-358.
[5] Chung C P， Hu H H. Pathogenesis of leukoaraiosis： Role of jugular venous re?ux[J]. Medical Hypotheses， 2010， 75 (1)：85-90.
[6] Simoni M， Mehta Z， Rothwell P M. Validity of CT versus MR brain imaging in studies of risk factors for Leukoaraiosis： a systematic review[J]. Cerebrovasc Dis， 2010，29(12)：300.
, http://www.100md.com
[7] Li H， Xu G L， Xiong Y Y， et al. Relationship between cerebral atherosclerosis and Leukoaraiosis in aged patients： results from DSA[J]. J Neuroimaging， 2014，24(4)：338-342.
[8] Mike O’Sullivan. Leukoaraiosis[J]. Pract Neurol， 2008，8(1)： 26-38.
[9] Feng C， Tan Y， Wu Y F， et al. Leukoaraiosis correlates with the neurologic deterioration after small subcortical infarction[J]. J Stroke Cerebrovasc Dis， 2014， 23(6)：1513-1518.
, 百拇医药
[10] De Groot M， Verhaaren Benjamin F J， De Boer R， et al. Changes in normal-appearing white matter precede development of white matter lesions[J]. Stroke， 2013，44(4)：1037-1042.
[11] Liao S Q， Li J C， Zhang M， et al. The association between leukoaraiosis and carotid atherosclerosis： a systematic review and meta-analysis[J]. Int J Neurosci， 2014， Early Online： 1-8.
[12] Chen Y F， Tseng Y L， Lan M Y， et al. The relationship of leukoaraiosis and the clinical severity of vascular Parkinsonism[J]. J Neurol Sci， 2014， 346(1-2)：255-259.
, 百拇医药
[13] Jinsoo U H， Uma Y， Cheng Y M， et al. In vivo vascular hallmarks of diffuse Leukoaraiosis[J]. J Magn Reson Imaging， 2010，32(1)：184-190.
[14] Bastos-Leite A J， Kuijer J P A， Rombouts S A R B， et al. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities[J]. AJNR Am J Neuroradiol， 2008，29(7)：1296-1301., 百拇医药(李倩 胡风云 赵路清)
参考文献
[1] Hachinski V C， Potter P， Merskey H. Leuko-araiosis[J]. Arch Neurol， 1987，44(1)：21-23.
[2] Auriel E， Bornstien N M， Berenyi E， et al. Clinical， radiological and pathological correlates of leukoaraiosis[J]. Acta Neurol Scand， 2011， 123 (1)：41-47.
[3] Mascalchi M， Ginestroni A， Toschi N. et al. The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and Leuko-Araiosis. A DTI and FMRI study[J]. Hum Brain Mapp， 2014，35(3)：819-830.
, 百拇医药
[4] Lin Q， Huang W Q， Tzeng C M. Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology[J]. Rev Neurosci， 2015， 26(3)： 343-358.
[5] Chung C P， Hu H H. Pathogenesis of leukoaraiosis： Role of jugular venous re?ux[J]. Medical Hypotheses， 2010， 75 (1)：85-90.
[6] Simoni M， Mehta Z， Rothwell P M. Validity of CT versus MR brain imaging in studies of risk factors for Leukoaraiosis： a systematic review[J]. Cerebrovasc Dis， 2010，29(12)：300.
, http://www.100md.com
[7] Li H， Xu G L， Xiong Y Y， et al. Relationship between cerebral atherosclerosis and Leukoaraiosis in aged patients： results from DSA[J]. J Neuroimaging， 2014，24(4)：338-342.
[8] Mike O’Sullivan. Leukoaraiosis[J]. Pract Neurol， 2008，8(1)： 26-38.
[9] Feng C， Tan Y， Wu Y F， et al. Leukoaraiosis correlates with the neurologic deterioration after small subcortical infarction[J]. J Stroke Cerebrovasc Dis， 2014， 23(6)：1513-1518.
, 百拇医药
[10] De Groot M， Verhaaren Benjamin F J， De Boer R， et al. Changes in normal-appearing white matter precede development of white matter lesions[J]. Stroke， 2013，44(4)：1037-1042.
[11] Liao S Q， Li J C， Zhang M， et al. The association between leukoaraiosis and carotid atherosclerosis： a systematic review and meta-analysis[J]. Int J Neurosci， 2014， Early Online： 1-8.
[12] Chen Y F， Tseng Y L， Lan M Y， et al. The relationship of leukoaraiosis and the clinical severity of vascular Parkinsonism[J]. J Neurol Sci， 2014， 346(1-2)：255-259.
, 百拇医药
[13] Jinsoo U H， Uma Y， Cheng Y M， et al. In vivo vascular hallmarks of diffuse Leukoaraiosis[J]. J Magn Reson Imaging， 2010，32(1)：184-190.
[14] Bastos-Leite A J， Kuijer J P A， Rombouts S A R B， et al. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities[J]. AJNR Am J Neuroradiol， 2008，29(7)：1296-1301., 百拇医药(李倩 胡风云 赵路清)