缺血缺氧导致心肌自噬的分子机制(4)
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, http://www.100md.com
[19] Zhou Y, Fang H, Lin S, et al.Qiliqiangxin protects against cardiac ischemia-reperfusion injury via activation of the mTOR pathway[J].Cell Physiol Biochem,2015,37(2):454-464.
[20] Galluzzi L, Kepp O, Trojel-Hansen C, et al. Mitochon-drial control of cellular life, stress, and death[J]. Circ Res,2012 ,111(12):1198-1207.
[21] Palikaras K, Tavernarakis N. Mitophagy in neurodegeneration and aging[J]. Front Genet,2012,19(3):297.
, http://www.100md.com
[22] Taylor R, Goldman S J. Mitophagy and disease: new avenues for pharmacological intervention[J]. Curr Pharm Des,2011,17(15):2056-2073.
[23] Okamoto K, Kondo-Okamoto N, Ohsumi Y. Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy[J]. Dev Cell,2009,17(1):87-97.
[24] Novak I, Kirkin V, McEwan D G, et al. Nix is a selective autophagy receptor for mitochondrial clearance[J]. EMBO Rep,2010,11(5):45-51.
, http://www.100md.com
[25] Liu L, Feng D, Chen G, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells[J]. Nat Cell Biol,2012,22(14):177-185.
[26] Kondo-Okamoto N, Noda N N, Suzuki S W, et al. Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy[J]. J Biol Chem,2012 ,287(19):10 631-10 638.
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, http://www.100md.com
[28] Zhu Y, Massen S, Terenzio M, et al. Modulation of serines 17 and 24 in the LC3 interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis[J]. J Biol Chem,2013,288(11):1099-1113.
[29] Chen G, Han Z, Feng D, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy[J]. Mol Cell,2014,54(8):362-377.
[30] Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum[J]. Autophagy, 2007,3(3): 285-287.
, 百拇医药
[31] Braakman I, Bulleid N J. Protein folding and modification in the mammalian endoplasmic reticulum[J]. Annual Review Biochem,2011, 80(8): 71-99.
[32] Pearson G L,Mellett N,Chu K Y,et al.Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells[J].Diabetologia,2014,57(1):129-139.
[33] Cebollero E, Reggiori F, Kraft C. Reticulophagy and ribophagy:regulated degradation of protein production factories[J]. Internat J Cell Biol, 2012, 2012(45): 182 834.
[34] Rubio N, Coupienne I, Di Valentin E, et al. Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species[J]. Autophagy, 2012,8(9):1312-1324.
(收稿日期:2015-08-18) (本文编辑:蔡元元), http://www.100md.com(李兴岳 郭润民 梁伟钧)
[17] Ganley I G, Lamdu H, Wang J, et al.ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy[J].J Biol Chem,2009,284(18):12 297-12 305.
[18] Sparks C A, Guertin D A.Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy[J].Oncogene,2010,29(26):3733-3744.
, http://www.100md.com
[19] Zhou Y, Fang H, Lin S, et al.Qiliqiangxin protects against cardiac ischemia-reperfusion injury via activation of the mTOR pathway[J].Cell Physiol Biochem,2015,37(2):454-464.
[20] Galluzzi L, Kepp O, Trojel-Hansen C, et al. Mitochon-drial control of cellular life, stress, and death[J]. Circ Res,2012 ,111(12):1198-1207.
[21] Palikaras K, Tavernarakis N. Mitophagy in neurodegeneration and aging[J]. Front Genet,2012,19(3):297.
, http://www.100md.com
[22] Taylor R, Goldman S J. Mitophagy and disease: new avenues for pharmacological intervention[J]. Curr Pharm Des,2011,17(15):2056-2073.
[23] Okamoto K, Kondo-Okamoto N, Ohsumi Y. Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy[J]. Dev Cell,2009,17(1):87-97.
[24] Novak I, Kirkin V, McEwan D G, et al. Nix is a selective autophagy receptor for mitochondrial clearance[J]. EMBO Rep,2010,11(5):45-51.
, http://www.100md.com
[25] Liu L, Feng D, Chen G, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells[J]. Nat Cell Biol,2012,22(14):177-185.
[26] Kondo-Okamoto N, Noda N N, Suzuki S W, et al. Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy[J]. J Biol Chem,2012 ,287(19):10 631-10 638.
[27] Aoki Y, Kanki T, Hirota Y, et al. Phosphorylation of Ser-ine 114 on Atg32 mediates mitophagy[J]. Mol Biol Cell,2011,22(9):3206-3217.
, http://www.100md.com
[28] Zhu Y, Massen S, Terenzio M, et al. Modulation of serines 17 and 24 in the LC3 interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis[J]. J Biol Chem,2013,288(11):1099-1113.
[29] Chen G, Han Z, Feng D, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy[J]. Mol Cell,2014,54(8):362-377.
[30] Bernales S, Schuck S, Walter P. ER-phagy: selective autophagy of the endoplasmic reticulum[J]. Autophagy, 2007,3(3): 285-287.
, 百拇医药
[31] Braakman I, Bulleid N J. Protein folding and modification in the mammalian endoplasmic reticulum[J]. Annual Review Biochem,2011, 80(8): 71-99.
[32] Pearson G L,Mellett N,Chu K Y,et al.Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells[J].Diabetologia,2014,57(1):129-139.
[33] Cebollero E, Reggiori F, Kraft C. Reticulophagy and ribophagy:regulated degradation of protein production factories[J]. Internat J Cell Biol, 2012, 2012(45): 182 834.
[34] Rubio N, Coupienne I, Di Valentin E, et al. Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species[J]. Autophagy, 2012,8(9):1312-1324.
(收稿日期:2015-08-18) (本文编辑:蔡元元), http://www.100md.com(李兴岳 郭润民 梁伟钧)