阿托伐他汀联合降压药对高血压患者颈动脉内中膜厚度和斑块的影响(1)
【摘要】 目的：探讨阿托伐他汀联合降压药对高血压患者颈动脉内中膜厚度(IMT)和斑块的影响。方法：选取本院2013年3月-2014年12月收治的原發性高血压伴IMT≥0.9 mm患者68例，采用随机数字表法将其均分为观察组和对照组，各34例，所有患者均予以降压方案对症治疗，观察组在上述基础上加用阿托伐他汀20 mg/d，治疗周期为18个月，所有患者于治疗前后以多普勒超声检测颈动脉IMT和斑块的变化，并检查治疗前后血脂的变化。结果：治疗后，对照组患者血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平与治疗前比较，差异均无统计学意义(P>0.05)；观察组患者TC、LDL-C水平均较治疗前明显下降，且均低于对照组治疗后，差异均有统计学意义(P<0.05)，而TG、HDL-C水平变化不明显，与治疗前及对照组治疗后比较，差异均无统计学意义(P>0.05)。对照组患者IMT、斑块长径及厚度均较治疗前略有减小，但差异均无统计学意义(P>0.05)，观察组患者IMT、斑块长径及厚度均较治疗前明显减小，且均小于对照组治疗后，差异均有统计学意义(P<0.05)。结论：阿托伐他汀联合降压药能降低高血压患者血脂，稳定斑块并使其退缩，降低IMT厚度，改善动脉粥样硬化的作用，有益于减少心脑血管并发症的发生。
【关键词】 阿托伐他汀； 高血压； 颈动脉内中膜； 颈动脉内斑块
【Abstract】 Objective：To investigate the effect of Atorvastatin combined antihypertensive drugs on carotid intima-media thickness(IMT) in patients with essential hypertension and plaque.Method：68 cases of primary hypertension combined with IMT≥0.9 mm in our hospital from March 2013 to September 2014 were selected，they were randomly divided into observation group and control group，34 cases in each group.All patients were treated with antihypertensive regimen，the observation group was treated with Atorvastatin 20 mg/d on the basis of the above，and the treatment cycle was 18 months.All patients were examined by doppler ultrasonography in pretherapy and post-treatment for carotid IMT and plaque changes，and the changes of blood lipid before and after treatment were checked.Result：After treatment，serum triglyceride(TG)，total cholesterol(TC)，high density lipoprotein cholesterol(HDL-C)，low density lipoprotein cholesterol (LDL-C) compared with before treatment，there were no statistically significant differences(P>0.05)，TC，LDL-C levels in observation group were significantly decreased than before treatment，and were lower than those in control group after treatment，the differences were statistically significant(P<0.05)，and TG，HDL-C level change were not obvious，compared with before treatment and control group after treatment，the differences were not statistically significant(P>0.05).In the control group，the length and thickness of IMT were slightly decreased，but the differences were not statistically significant(P>0.05)，IMT，plaque length and thickness in observation group were significantly decreased compared with before treatment，and were less than those in control group after treatment，the differences were statistically significant(P<0.05).Conclusion：Atorvastatin combined with antihypertensive drugs can reduce blood lipids in patients with hypertension，stable plaque and make it shrink，reduce the thickness of IMT，improve the role of atherosclerosis，beneficial to reduce the incidence of cardiovascular and cerebrovascular complications., http://www.100md.com(吴岚 揭珏 周琛)
【关键词】 阿托伐他汀； 高血压； 颈动脉内中膜； 颈动脉内斑块
【Abstract】 Objective：To investigate the effect of Atorvastatin combined antihypertensive drugs on carotid intima-media thickness(IMT) in patients with essential hypertension and plaque.Method：68 cases of primary hypertension combined with IMT≥0.9 mm in our hospital from March 2013 to September 2014 were selected，they were randomly divided into observation group and control group，34 cases in each group.All patients were treated with antihypertensive regimen，the observation group was treated with Atorvastatin 20 mg/d on the basis of the above，and the treatment cycle was 18 months.All patients were examined by doppler ultrasonography in pretherapy and post-treatment for carotid IMT and plaque changes，and the changes of blood lipid before and after treatment were checked.Result：After treatment，serum triglyceride(TG)，total cholesterol(TC)，high density lipoprotein cholesterol(HDL-C)，low density lipoprotein cholesterol (LDL-C) compared with before treatment，there were no statistically significant differences(P>0.05)，TC，LDL-C levels in observation group were significantly decreased than before treatment，and were lower than those in control group after treatment，the differences were statistically significant(P<0.05)，and TG，HDL-C level change were not obvious，compared with before treatment and control group after treatment，the differences were not statistically significant(P>0.05).In the control group，the length and thickness of IMT were slightly decreased，but the differences were not statistically significant(P>0.05)，IMT，plaque length and thickness in observation group were significantly decreased compared with before treatment，and were less than those in control group after treatment，the differences were statistically significant(P<0.05).Conclusion：Atorvastatin combined with antihypertensive drugs can reduce blood lipids in patients with hypertension，stable plaque and make it shrink，reduce the thickness of IMT，improve the role of atherosclerosis，beneficial to reduce the incidence of cardiovascular and cerebrovascular complications., http://www.100md.com(吴岚 揭珏 周琛)