妊娠期高血压疾病孕妇血管内皮功能变化研究(1)
【摘要】 目的：对血管回声跟踪技术(E-Tracking)用于评价孕晚期妊娠期高血压疾病(HDCP)患者的血管内皮功能变化的应用价值进行探讨研究。方法：选择本院于2014年7月-2016年10月间收治的孕晚期正常孕妇36例(对照组)和HDCP患者(观察组)60例，应用E-Tracking技术对两组患者足背动脉的弹性系数(Eρ)、硬化度(β)、膨大系数(AI)、动脉顺应性(AC)以及单点脉搏波传导速率(PWVβ)超声测量，以及一氧化氮(NO)、血清内皮素(ET)的水平进行检测。结果：观察组Eρ、β、AI、PWVβ、ET值与对照组相比显著较高，而AC、NO2-/NO3-值显著较低，差异均有统计学意义(P<0.05)。在观察组中，子痫前期患者的Eρ、β、AI、PWVβ、ET值显著高于妊娠期高血压患者，而AC、NO2-/NO3-值较低，比较差异均有统计学意义(P<0.05)。结论：HDCP患者存在血管内皮依赖性舒张功能损伤，利用血管回声跟踪技术能对患者的内皮损伤成能进行有效的检测。
【关键词】 妊娠期高血压疾病； 血管回声跟踪技术； 内皮功能
【Abstract】 Objective：The discussion and research of the application of vascular echo-tracking technique (E-tracking) for the evaluation of vascular endothelial metergasis in the hypertensive disorder complicating pregnancy (HDCP) patients with late pregnancy.Method：Thirty-six cases of normal pregnant women (control group) and sixty cases of HDCP patients (observation group) in the late pregnancy in our hospital from July 2014 to October 2016 were selected.E-Tracking technique was utilized for the ultrasonic measurement of such parameters as elasticity coefficient (Eρ)、hardenability (β)、expansion coefficient (AI)、arterial compliance (AC)，single point pulse wave velocity (PWVβ) ，the detection of nitrogen oxide (NO) and serum endothelin (ET) of the arteriae dorsalis pedis in two groups.Result：The observation group exhibited remarkably higher in Eρ、β、AI、PWVβ and ET，lower AC and NO2-/NO3- than those of the control group，the differences were statistically significant(P<0.05).In the observation group， the preeclampsia patients exhibited remarkably higher in Eρ、β、AI、PWVβ and ET，lower AC and NO2-/NO3- than those of the HDCP patients，the differences were statistically significant(P<0.05).Conclusion：The HDCP patients probably suffered vascular endothelium dependent diastolic dysfunction and E-Tracking technique is able to effectively monitor the vascular endothelin injury of the patients.
【Key words】 Hypertensive disorder complicating pregnancy； Vascular echo-tracking technique； Vascular endothelial metergasis
First-author’s address：Zhuhai People’s Hospital，Zhuhai 519000，China
doi：10.3969/j.issn.1674-4985.2017.07.012
妊娠期高血壓疾病(hypertensive disorder complicating pregnancy，HDCP)是一种临床上严重影响母婴安全的产科常见重症疾病，该病的发病机制目前尚未得到完全阐明，而血管内皮损伤学说得到学界的广泛认可[1-2]。E-Tracking技术能够反映血管内皮功能，其在内科领域得到了较为广泛的应用，然而在产科领域的报道中却鲜有提及[3-5]。本研究以前瞻性的研究方法，通过超声测量患者足背动脉的弹性系数(Eρ)、硬化度(β)、膨大系数(AI)、动脉顺应性(AC)、单点脉搏波传导速率(PWVβ)，以及一氧化氮(NO)、血清内皮素(ET)水平对患者的血管内皮功能进行联合评价，旨在对E-Tracking技术用于评价HDCP患者的血管内皮功能变化的临床价值进行探讨研究。, http://www.100md.com(肖贤 王勇 张恒)
【关键词】 妊娠期高血压疾病； 血管回声跟踪技术； 内皮功能
【Abstract】 Objective：The discussion and research of the application of vascular echo-tracking technique (E-tracking) for the evaluation of vascular endothelial metergasis in the hypertensive disorder complicating pregnancy (HDCP) patients with late pregnancy.Method：Thirty-six cases of normal pregnant women (control group) and sixty cases of HDCP patients (observation group) in the late pregnancy in our hospital from July 2014 to October 2016 were selected.E-Tracking technique was utilized for the ultrasonic measurement of such parameters as elasticity coefficient (Eρ)、hardenability (β)、expansion coefficient (AI)、arterial compliance (AC)，single point pulse wave velocity (PWVβ) ，the detection of nitrogen oxide (NO) and serum endothelin (ET) of the arteriae dorsalis pedis in two groups.Result：The observation group exhibited remarkably higher in Eρ、β、AI、PWVβ and ET，lower AC and NO2-/NO3- than those of the control group，the differences were statistically significant(P<0.05).In the observation group， the preeclampsia patients exhibited remarkably higher in Eρ、β、AI、PWVβ and ET，lower AC and NO2-/NO3- than those of the HDCP patients，the differences were statistically significant(P<0.05).Conclusion：The HDCP patients probably suffered vascular endothelium dependent diastolic dysfunction and E-Tracking technique is able to effectively monitor the vascular endothelin injury of the patients.
【Key words】 Hypertensive disorder complicating pregnancy； Vascular echo-tracking technique； Vascular endothelial metergasis
First-author’s address：Zhuhai People’s Hospital，Zhuhai 519000，China
doi：10.3969/j.issn.1674-4985.2017.07.012
妊娠期高血壓疾病(hypertensive disorder complicating pregnancy，HDCP)是一种临床上严重影响母婴安全的产科常见重症疾病，该病的发病机制目前尚未得到完全阐明，而血管内皮损伤学说得到学界的广泛认可[1-2]。E-Tracking技术能够反映血管内皮功能，其在内科领域得到了较为广泛的应用，然而在产科领域的报道中却鲜有提及[3-5]。本研究以前瞻性的研究方法，通过超声测量患者足背动脉的弹性系数(Eρ)、硬化度(β)、膨大系数(AI)、动脉顺应性(AC)、单点脉搏波传导速率(PWVβ)，以及一氧化氮(NO)、血清内皮素(ET)水平对患者的血管内皮功能进行联合评价，旨在对E-Tracking技术用于评价HDCP患者的血管内皮功能变化的临床价值进行探讨研究。, http://www.100md.com(肖贤 王勇 张恒)