特发性血小板减少性紫癜合并血小板无效输注的临床治疗研究(1)
【摘要】 目的：研究與分析特发性血小板减少性紫癜合并血小板无效输注的临床治疗。方法：选取2014年4月-2016年8月本院收治的特发性血小板减少性紫癜合并血小板无效输注的26例患者作为研究对象，采用奇偶分组法分为对照组和观察组，各13例。两组患者入院后均进行常规治疗，在此基础上，对照组患者加大血小板输注剂量进行治疗，而观察组患者则在输注血小板前静脉滴注丙种球蛋白治疗。治疗过程中，详细记录两组患者出血症状消失时间、血小板上升时间、血小板达到正常时间及住院时间，对比两组患者各临床指标差异；治疗结束后，对比两组患者的临床治疗效果；分别检测两组患者治疗前和治疗后1、24 h的血小板数量，对比变化情况；同时对比观察两组患者的不良反应发生率。结果：观察组患者出血症状消失时间、血小板上升时间、血小板达到正常时间及住院时间均显著优于对照组，差异均有统计学意义(P<0.05)。观察组患者临床治疗总有效率高于对照组，差异有统计学意义(P<0.05)。治疗前，两组患者血小板数量比较，差异无统计学意义(P>0.05)；治疗后1、24 h，两组患者血小板数量均明显多于治疗前，差异均有统计学意义(P<0.05)，且观察组患者血小板数量均多于对照组，差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较，差异无统计学意义(P>0.05)。结论：对特发性血小板减少性紫癜合并血小板无效输注患者，采用丙种球蛋白静脉滴注治疗效果较好，可在较短时间内使血小板数量增多，达到止血效果，从而缩短患者住院时间，且治疗过程中不良反应较少，安全性较高，值得临床推广应用。
【关键词】 特发性血小板减少性紫癜； 血小板无效输注； 丙种球蛋白
Research of Clinical Treatment of Idiopathic Thrombocytopenic Purpura Complicated with Ineffective Platelet Transfusion/HUANG Jun.//Medical Innovation of China，2017，14(09)：018-021
【Abstract】 Objective：To study and analyze the clinical treatment of idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion.Method：26 patients with idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion and who accepted treatments in our hospital from April 2014 to August 2016 were selected as the research objects，and they were divided into control group and observation group by the even and odd grouping method，13 cases in each group.Two groups of patients were given routine treatment，and on this basis，the patients in control group were increased platelet transfusion dose for treatment，while the patients in observation group were given intravenous gamma globulin treatment before intravenous immunoglobulin therapy.Then，the time of disappearance of bleeding symptoms，the time of platelet rise，the normal time of platelet and the hospitalization time of two groups were recorded during the treatment，and the differences of clinical parameters of two groups were compared.After the end of treatment，the clinical treatment effect of two groups were compared according to the standard of clinical effect，and the platelet count of two groups were detected before and after treatment for 1 h and 24 h，and the change situation were compared.At the same time，the occurrence of adverse reaction symptoms and number of two groups were recorded during the treatment，and the incidence of adverse reactions were compared.Result：The time of disappearance of bleeding symptoms，the time of platelet rise，the normal time of platelet and the hospitalization time in observation group were significantly better than those in control group，the differences were statistically significant(P<0.05).The total effective rate in observation group was higher than that of control group，the difference was statistically significant(P<0.05).The number of platelets of two groups before treatment was less，and there was no significant difference between the two groups(P>0.05)；the platelet count after treatment for 1 h and 24 h were significantly higher than those before treatment，the differences were statistically significant(P<0.05)，and the platelet count after treatment for 1 h and 24 h in observation group were significantly more than those in control group the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion：The treatment effect of intravenous immunoglobulin infusion in treatment of patients with idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion are better，which can increase the number of platelets in a short period of time，and achieve the hemostatic effect，so as to shorten the hospitalization time，and the adverse reactions are less in the treatment process，the safety is high，thus this method can be extended to clinical application., http://www.100md.com(黄俊)
【关键词】 特发性血小板减少性紫癜； 血小板无效输注； 丙种球蛋白
Research of Clinical Treatment of Idiopathic Thrombocytopenic Purpura Complicated with Ineffective Platelet Transfusion/HUANG Jun.//Medical Innovation of China，2017，14(09)：018-021
【Abstract】 Objective：To study and analyze the clinical treatment of idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion.Method：26 patients with idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion and who accepted treatments in our hospital from April 2014 to August 2016 were selected as the research objects，and they were divided into control group and observation group by the even and odd grouping method，13 cases in each group.Two groups of patients were given routine treatment，and on this basis，the patients in control group were increased platelet transfusion dose for treatment，while the patients in observation group were given intravenous gamma globulin treatment before intravenous immunoglobulin therapy.Then，the time of disappearance of bleeding symptoms，the time of platelet rise，the normal time of platelet and the hospitalization time of two groups were recorded during the treatment，and the differences of clinical parameters of two groups were compared.After the end of treatment，the clinical treatment effect of two groups were compared according to the standard of clinical effect，and the platelet count of two groups were detected before and after treatment for 1 h and 24 h，and the change situation were compared.At the same time，the occurrence of adverse reaction symptoms and number of two groups were recorded during the treatment，and the incidence of adverse reactions were compared.Result：The time of disappearance of bleeding symptoms，the time of platelet rise，the normal time of platelet and the hospitalization time in observation group were significantly better than those in control group，the differences were statistically significant(P<0.05).The total effective rate in observation group was higher than that of control group，the difference was statistically significant(P<0.05).The number of platelets of two groups before treatment was less，and there was no significant difference between the two groups(P>0.05)；the platelet count after treatment for 1 h and 24 h were significantly higher than those before treatment，the differences were statistically significant(P<0.05)，and the platelet count after treatment for 1 h and 24 h in observation group were significantly more than those in control group the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion：The treatment effect of intravenous immunoglobulin infusion in treatment of patients with idiopathic thrombocytopenic purpura complicated with ineffective platelet transfusion are better，which can increase the number of platelets in a short period of time，and achieve the hemostatic effect，so as to shorten the hospitalization time，and the adverse reactions are less in the treatment process，the safety is high，thus this method can be extended to clinical application., http://www.100md.com(黄俊)