雄激素性脱发的皮肤镜下临床特征及疗效分析(1)
【摘要】 目的：分析皮肤镜下雄激素性脱发疾病的临床特征表现与治疗相关情况。方法：收集2015年6月-2016年4月于中山大学附属第一医院皮肤科治疗的100例脱发患者作为观察组，采集患者目标靶区大体及微观皮肤镜临床表现图像；另外选择同期来中山大学附属第一医院皮肤科进行体检的50例毛发健康志愿者作为对照组，采用7级评分法进行疗效评价。结果：皮肤镜下脱发性疾病患者的临床特征主要包括>20%的毛发直径变细、毳毛增多、褐色毛周征、局部无毛征、色素沉着与黄点征。治疗前，观察组皮肤镜征象各项指标均高于对照组，差异均有统计学意义(P<0.05)。观察组100例患者均参与复诊，总有效率为75%。观察组患者治疗后皮肤镜征象各指标与治疗前比较，差异均有统计学意义(P<0.05)。结论：皮肤镜在早期诊断脱发性疾病与疗效评价上有着重要的应用价值，>20%的毛发直径变细是早期诊断脱发性疾病的一个重要标准，使用非那雄胺联合5%米诺地尔方案治疗雄激素性脱发的效果确切。
【关键词】 皮肤镜； 脱發性疾病； 临床特征； 疗效； 雄激素性脱发
Analysis of Clinical Features and Curative Effect of Androgenetic Alopecia by Demoscopy/ZHUANG Niang-qiao，TANG Xu-hua，LI Jun-shan，et al.//Medical Innovation of China，2017，14(12)：108-110
【Abstract】 Objective：To analyze the clinical features and curative effect of androgenetic alopecia by demoscopy.Method：From June 2015 to April 2016，100 cases with androgenetic alopecia at the First Hospital，Sun Yat-sen University were selected as the observation group，the target regions image by visual and demoscopy of all the cases were collected，and 50 cases with healthy hair were selected as the control group，the curative effect by 7 grading method was evaluated.Result：The clinical features of image by demoscopy in patients with hair loss disease included more than 20% of hair diameter diminish，vellus hair increased，suntan around the hair，partly acomia，chromatosis and yellow dot sign.Before treatment，the indicators of demoscopy in observation group were higher than those of the control group，the differences were statistically significant(P<0.05).The observation group of 100 patients were involved in the follow-up，the total effective rate was 75%.The observation group after treatment， the indicators of the signs compared before treatment，the differences were statistically significant(P<0.05).Conclusion：Dermatoscope plays an important role in early diagnostic and therapeutic effect evaluation of hair loss disease，diameter diminish more than 20% of hair is main diagnostic criterion of it，using combination therapy with Finasteride and 5% Minoxidil treat androgenetic alopecia has definite clinical effect.
【Key words】 Dermatoscope； Hair loss disease； Clinical feature； Curative effect； Androgenetic alopecia
First-author’s address：Zhongda Huiya Hospital of Huizhou City，Huizhou 516081，China
doi：10.3969/j.issn.1674-4985.2017.12.030
临床工作中发现因脱发疾病就诊的患者从青年到中老年，包括男性和女性，脱发对人们的影响不受年龄的限制，但主要是20～50岁人群[1]。常见脱发性疾病包括斑秃、雄激素性脱发、休止期脱发、拔毛癖、牵拉性脱发和梅毒性脱发等，仅凭肉眼观察，难以做出准确及客观的判断[2]。皮肤镜是一种无创的显微镜样诊断设备，皮肤科医师常用来观察不为肉眼所见的皮损细微表现。根据皮损颜色和显微结构特征可以帮助皮肤科医师提高皮肤病诊断的正确率。皮肤镜应用于毛发疾病的诊疗工作中，可在治疗中观察毛发的覆盖情况、生长速度、毛囊周期、毛干形态学、头皮组织等判断疗效，为患者提供无创性、安全、有效的医疗服务[3]。因此，探讨雄激素性脱发在皮肤镜下特征性表现及治疗功效，具有重要的临床意义。, http://www.100md.com(庄娘桥 唐旭华 李俊珊 曹孙香 章星琪)
【关键词】 皮肤镜； 脱發性疾病； 临床特征； 疗效； 雄激素性脱发
Analysis of Clinical Features and Curative Effect of Androgenetic Alopecia by Demoscopy/ZHUANG Niang-qiao，TANG Xu-hua，LI Jun-shan，et al.//Medical Innovation of China，2017，14(12)：108-110
【Abstract】 Objective：To analyze the clinical features and curative effect of androgenetic alopecia by demoscopy.Method：From June 2015 to April 2016，100 cases with androgenetic alopecia at the First Hospital，Sun Yat-sen University were selected as the observation group，the target regions image by visual and demoscopy of all the cases were collected，and 50 cases with healthy hair were selected as the control group，the curative effect by 7 grading method was evaluated.Result：The clinical features of image by demoscopy in patients with hair loss disease included more than 20% of hair diameter diminish，vellus hair increased，suntan around the hair，partly acomia，chromatosis and yellow dot sign.Before treatment，the indicators of demoscopy in observation group were higher than those of the control group，the differences were statistically significant(P<0.05).The observation group of 100 patients were involved in the follow-up，the total effective rate was 75%.The observation group after treatment， the indicators of the signs compared before treatment，the differences were statistically significant(P<0.05).Conclusion：Dermatoscope plays an important role in early diagnostic and therapeutic effect evaluation of hair loss disease，diameter diminish more than 20% of hair is main diagnostic criterion of it，using combination therapy with Finasteride and 5% Minoxidil treat androgenetic alopecia has definite clinical effect.
【Key words】 Dermatoscope； Hair loss disease； Clinical feature； Curative effect； Androgenetic alopecia
First-author’s address：Zhongda Huiya Hospital of Huizhou City，Huizhou 516081，China
doi：10.3969/j.issn.1674-4985.2017.12.030
临床工作中发现因脱发疾病就诊的患者从青年到中老年，包括男性和女性，脱发对人们的影响不受年龄的限制，但主要是20～50岁人群[1]。常见脱发性疾病包括斑秃、雄激素性脱发、休止期脱发、拔毛癖、牵拉性脱发和梅毒性脱发等，仅凭肉眼观察，难以做出准确及客观的判断[2]。皮肤镜是一种无创的显微镜样诊断设备，皮肤科医师常用来观察不为肉眼所见的皮损细微表现。根据皮损颜色和显微结构特征可以帮助皮肤科医师提高皮肤病诊断的正确率。皮肤镜应用于毛发疾病的诊疗工作中，可在治疗中观察毛发的覆盖情况、生长速度、毛囊周期、毛干形态学、头皮组织等判断疗效，为患者提供无创性、安全、有效的医疗服务[3]。因此，探讨雄激素性脱发在皮肤镜下特征性表现及治疗功效，具有重要的临床意义。, http://www.100md.com(庄娘桥 唐旭华 李俊珊 曹孙香 章星琪)