血压昼夜节律变化对急性脑梗死患者预后的影响研究(1)
【摘要】 目的：探討血压昼夜节律变化对急性脑梗死患者治疗效果的影响，并分析其与预后的相关性。方法：选取2014年1月-2016年12月于本院就诊的150例急性脑梗死患者作为观察对象，根据血压夜间下降率情况将患者分为杓型组、非杓型组及反杓型组，其中杓型组患者56例，非杓型组患者60例，反杓型组患者34例。比较三组治疗前后神经功能及生活质量变化情况，并分析所有患者夜间血压下降率与神经功能及生活质量的相关性。结果：在12周的治疗过程中，三组NIHSS评分均呈下降趋势，GQOLI-74评分均呈升高趋势。入组时及治疗后4周，三组间NIHSS评分及GQOLI-74评分比较差异均无统计学意义(P>0.05)；治疗后8、12周，三组间NIHSS评分及GQOLI-74评分比较差异均有统计学意义(P<0.05)，其中NIHSS评分以杓型组最低，反杓型最高，GQOLI-74评分以杓型组最高，反杓型最低。同时，血压夜间下降率与NIHSS评分变化率及GQOLI-74评分变化率均呈显著的正向直线相关性(P<0.05)。结论：血压昼夜节律变化可对急性脑梗死患者的预后造成严重的影响，其中以杓型血压患者预后较为理想，且血压变化率越高，其预后越理想。
【关键词】 血压昼夜节律； 急性脑梗死； 神经功能； 生活质量； 预后
Research of Blood Pressure Circadian Rhythm Changes for Prognosis Influence of Patients with Acute Cerebral Infarction/YE Xin-gui，SONG Jie-jiang.//Medical Innovation of China，2017，14(14)：111-114
【Abstract】 Objective：To explore the influence of the changes of blood pressure circadian rhythm in patients with acute cerebral infarction and analyze its correlation with prognosis.Method：From January 2014 to December 2016，150 patients with acute cerebral infarction treated in our hospital were selected and divided into scoop type group(56 cases)，non-dipper group(60 cases) and convex type group(34 cases) according to the situation of nighttime blood pressure drop rate，compared the nerve function and quality of life at prior-treatment and posttreatment of three groups，then analyzed the influence of nighttime blood pressure drop rate for patient’s neural function and quality of life.Result：After 12 weeks of treatment，NIHSS score of three groups were all downswing，GQOLI-74 score were all escalating trend.NIHSS score and GQOLI-74 score of three groups at access groups and treated 4 weeks had no statistically significant(P>0.05).At 8，12 weeks after the treatment，NIHSS score and GQOLI-74 score among three groups had significant statistic differences，the lowest NIHSS score was the scoop type group，the highest NIHSS score was the convex type group(P<0.05)，the highest GQOLI-74 score was the scoop type group，the lowest GQOLI-74 score was the convex type group(P<0.05).We also found a positive correlation between the nighttime blood pressure drop rate and the score of NIHSS and GQOLI-74(P<0.05).Conclusion：Blood pressure circadian rhythm changes can seriously influence the prognosis of patients with acute cerebral infarction，the convex type group has best prognosis，the larger the change rate，the better the prognosis.
【Key words】 Blood pressure circadian rhythm； Acute cerebral infarction； Nerve function； Quality of life； Prognosis, 百拇医药(叶新桂 宋杰江)
【关键词】 血压昼夜节律； 急性脑梗死； 神经功能； 生活质量； 预后
Research of Blood Pressure Circadian Rhythm Changes for Prognosis Influence of Patients with Acute Cerebral Infarction/YE Xin-gui，SONG Jie-jiang.//Medical Innovation of China，2017，14(14)：111-114
【Abstract】 Objective：To explore the influence of the changes of blood pressure circadian rhythm in patients with acute cerebral infarction and analyze its correlation with prognosis.Method：From January 2014 to December 2016，150 patients with acute cerebral infarction treated in our hospital were selected and divided into scoop type group(56 cases)，non-dipper group(60 cases) and convex type group(34 cases) according to the situation of nighttime blood pressure drop rate，compared the nerve function and quality of life at prior-treatment and posttreatment of three groups，then analyzed the influence of nighttime blood pressure drop rate for patient’s neural function and quality of life.Result：After 12 weeks of treatment，NIHSS score of three groups were all downswing，GQOLI-74 score were all escalating trend.NIHSS score and GQOLI-74 score of three groups at access groups and treated 4 weeks had no statistically significant(P>0.05).At 8，12 weeks after the treatment，NIHSS score and GQOLI-74 score among three groups had significant statistic differences，the lowest NIHSS score was the scoop type group，the highest NIHSS score was the convex type group(P<0.05)，the highest GQOLI-74 score was the scoop type group，the lowest GQOLI-74 score was the convex type group(P<0.05).We also found a positive correlation between the nighttime blood pressure drop rate and the score of NIHSS and GQOLI-74(P<0.05).Conclusion：Blood pressure circadian rhythm changes can seriously influence the prognosis of patients with acute cerebral infarction，the convex type group has best prognosis，the larger the change rate，the better the prognosis.
【Key words】 Blood pressure circadian rhythm； Acute cerebral infarction； Nerve function； Quality of life； Prognosis, 百拇医药(叶新桂 宋杰江)