【摘要】 鼻息肉是鼻腔炎性黏膜上带蒂或广基的高度水肿的炎性组织，成人鼻息肉发生率为1%～4%，术后易复发。鼻咽癌是鼻咽部恶性肿瘤，病变部位隐匿、早期症状不典型、预后差，5年生存率大约50%。相关研究揭示了局部缺氧环境在鼻息肉和鼻咽癌发病、进展中有重要意义，其中HIF-1作为独特低氧环境细胞因子可参与调控细胞代谢、促进细胞增殖、加重炎症反应在鼻息肉和鼻咽癌的发生过程中可能扮有重要角色。

    【关键词】 鼻息肉； 鼻咽癌； HIF-1

    【Abstract】 Nasal polyps are highly inflammatory tissues with pedicle or wide base in the nasal mucosa，the incidence of adult nasal polyps was 1%-4%，which was easy to recur.Nasopharyngeal carcinoma is a malignant tumor of the nasopharynx，the location of the lesion and early symptoms are not typical，the prognosis is poor，5 years survival rate was about 50%.Related studies have shown that the local hypoxic environment is of great significance in the development of nasal polyps and nasopharyngeal carcinoma ......