非酒精性脂肪肝病患者血浆同型半胱氨酸与颈动脉内中膜厚度的相关性研究(1)
【摘要】 目的：探討非酒精性脂肪肝病(NAFLD)患者同型半胱氨酸(Hcy)与颈动脉内中膜厚度(IMT)的相关性及发病的危险因素。方法：选取2013年1月-2015年6月本院体检人群中经B超检查为NAFLD的患者112例为NAFLD组，并选取同期B超检查正常的人群130例为对照组(NC组)。检测两组血浆Hcy，丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)，空腹胰岛素(FINS)，测定左右颈动脉IMT(IMT-L、IMT-R)，同时计算体重指数(BMI)，胰岛素抵抗指数(HOMA-IR)，并进行相关性分析。结果：NAFLD组BMI、TG、HOMA-IR、Hcy、IMT-L、IMT-R均高于NC组(P<0.01)；相关性分析显示，NAFLD组平均IMT与BMI、TG、HOMA-IR、Hcy均呈正相关(P<0.05)；Logistic回归分析显示，BMI、TG、HOMA-IR、Hcy是NAFLD的主要危险因素(P<0.01)。结论：Hcy是NAFLD发病的危险因素，且Hcy水平与IMT呈正相关，故临床需加强对危险因素的监测、控制，早期评估心血管风险，以减少心脑血管事件的发生。
, http://www.100md.com
【关键词】 非酒精性脂肪肝； 同型半胱氨酸； 颈动脉内中膜厚度
Study on Correlation between Plasma Homocysteine and Carotid Artery Intima-media Thickness in Patients with Non-alcoholic Fatty Liver Disease/WANG Yan，TU Ping，XU Dingbo，et al.//Medical Innovation of China，2017，14(35)：021-024
【Abstract】 Objective：To investigate the correlation between homocysteine(Hcy) and carotid artery intima-media thickness(IMT) in patients with non-alcoholic fatty liver disease(NAFLD) and risk factors.Method：A total of 112 cases of NAFLD were examined by B ultrasonic examination in the physical examination population of our hospital from January 2013 to June 2015 were selected as NAFLD group，and 130 cases who had normal B-mode ultrasound examination were selected as control group(NC group).The serum levels of homocysteine，alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，total cholesterol(TC)，triglyceride(TG)，high density lipoprotein cholesterol (HDL-C)，low density lipoprotein cholesterol(LDL-C)，fasting plasma glucose(FPG)，fasting insulin(FINS)，left and right carotid artery IMT(IMT-L，IMT-R) were detected，body mass index(BMI) and Homeostasis model assessment of insulin resistance(HOMA-IR) of two groups were calculated.Result：BMI，TG，HOMA-IR，Hcy，IMT-L and IMT-R of NAFLD group were all higher than those of NC group(P<0.01).The correlation analysis showed that the average IMT in NAFLD group were positively correlated with BMI，TG，HOMA-IR and Hcy(P<0.05).Logistic regression analysis showed that BMI，TG，HOMA-IR and Hcy were the major risk factors for NAFLD(P<0.01).Conclusion：Hcy is a risk factor for the onset of NAFLD，and the level of Hcy is positively correlated with IMT.Therefore，it is necessary to strengthen the monitoring and control of the risk factors and to assess the cardiovascular risk early in order to reduce the occurrence of cardiovascular events.
【Key words】 Non-alcoholic fatty liver disease； Homocysteine； Carotid artery intima-media thickness, 百拇医药(王艳 涂萍 徐定波 李圣坚 杨枝)
, http://www.100md.com
【关键词】 非酒精性脂肪肝； 同型半胱氨酸； 颈动脉内中膜厚度
Study on Correlation between Plasma Homocysteine and Carotid Artery Intima-media Thickness in Patients with Non-alcoholic Fatty Liver Disease/WANG Yan，TU Ping，XU Dingbo，et al.//Medical Innovation of China，2017，14(35)：021-024
【Abstract】 Objective：To investigate the correlation between homocysteine(Hcy) and carotid artery intima-media thickness(IMT) in patients with non-alcoholic fatty liver disease(NAFLD) and risk factors.Method：A total of 112 cases of NAFLD were examined by B ultrasonic examination in the physical examination population of our hospital from January 2013 to June 2015 were selected as NAFLD group，and 130 cases who had normal B-mode ultrasound examination were selected as control group(NC group).The serum levels of homocysteine，alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，total cholesterol(TC)，triglyceride(TG)，high density lipoprotein cholesterol (HDL-C)，low density lipoprotein cholesterol(LDL-C)，fasting plasma glucose(FPG)，fasting insulin(FINS)，left and right carotid artery IMT(IMT-L，IMT-R) were detected，body mass index(BMI) and Homeostasis model assessment of insulin resistance(HOMA-IR) of two groups were calculated.Result：BMI，TG，HOMA-IR，Hcy，IMT-L and IMT-R of NAFLD group were all higher than those of NC group(P<0.01).The correlation analysis showed that the average IMT in NAFLD group were positively correlated with BMI，TG，HOMA-IR and Hcy(P<0.05).Logistic regression analysis showed that BMI，TG，HOMA-IR and Hcy were the major risk factors for NAFLD(P<0.01).Conclusion：Hcy is a risk factor for the onset of NAFLD，and the level of Hcy is positively correlated with IMT.Therefore，it is necessary to strengthen the monitoring and control of the risk factors and to assess the cardiovascular risk early in order to reduce the occurrence of cardiovascular events.
【Key words】 Non-alcoholic fatty liver disease； Homocysteine； Carotid artery intima-media thickness, 百拇医药(王艳 涂萍 徐定波 李圣坚 杨枝)
参见：首页 > 医疗版 > 疾病专题 > 消化内科 > 肝胆疾病 > 脂肪肝