基于PubMed数据库对梅尼埃病的聚类分析(1)
【摘要】 目的：探索分析近十年对梅尼埃病的研究热点。方法：选用PubMed数据库，检索式为“Meniere Disease”[Mesh] AND (“2007/11/11”[PDat]：“2017/11/07”[PDat])，检索结果采用书目信息挖掘系统(BICOMS)软件进行常规文献计量学分析，使用gCLUTO 2.1软件进行聚类及可视化分析。结果：共检索到文献1084篇，统计分析后划分为以下8个主题：鼓室内给药庆大霉素可有效控制药物难治性梅尼埃病造成的眩晕；内淋巴积水是梅尼埃病的特征性病理表现；前庭功能障碍与精神类疾病的关系；利用诱发前庭诱发肌源性电位方法评价内耳功能；内淋巴囊手术可有效降低眩晕的发作率与发作程度；膜迷路积水程度影响听力损伤程度；前庭功能障碍引发其他疾病；利用颈部前庭诱发肌源性电位诊断方法可区分梅尼埃病和前庭偏头疼。结论：聚类分析方法很好地体现了目前临床对梅尼埃病的研究方向。
【关键词】 梅尼埃病； 文献计量学； 可视化； 研究热点
, http://www.100md.com Biclustering Analysis of Meniere Disease Research Based on Pubmed Database/CHANG Delong.//Medical Innovation of China，2018，15(01)：136-139
【Abstract】 Objective：To explore and analysis the hotspots of Meniere Disease in recently ten years.Method：The PubMed database was selected “Meniere Disease”[Mesh] AND (“2007/11/11”[PDat]：“2017/11/07”[PDat]).The results were retrieved by bibliographic information mining system (BICOMS) software，and gCLUTO 2.1 software was used for biclustering analysis and visualization analysis.Result：A total of 1084 literatures were retrieved， and the statistical analysis was divided into eight topics：intratympanic gentamicin can effectively control the vertigo that was caused by medically refractory unilateral Meniere disease；endolymphatic hydrops was a characteristic pathological manifestation of Meniere disease；the relationship between vestibular dysfunction and psychiatric disorders；evaluation of inner ear function by inducing vestibular evoked myogenic potential(VEMP)；endolymphatic sac surgery was effective in reducing the incidence and severity of vertigo attacks；the degree of endolymphatic hydrops affects the degree of hearing impairment；vestibular dysfunction causes other diseases；cVEMP can be used as a diagnostic test to differentiate Meniere disease from vestibular migraine.Conclusion：The biclustering analysis method is a good example of the current research direction on Meniere disease.
, 百拇医药
【Key words】 Meniere disease； Bibliometrics； Visualization； Research hotspots
First-author’s address：The Chinese People’s Liberation Army 463 Hospital，Shenyang 110000，China
doi：10.3969/j.issn.1674-4985.2018.01.038
梅尼埃病(Meniere Disease，MD)的最早報道要追溯至1861年，由法国医生Meniere所描述，他认为该病的本质是患者内耳功能紊乱，并伴随出现眩晕、听见异常声音和听力逐渐下降等情况[1]。现代医学权威机构前庭疾病分类委员会将MD定义为以反复自发性发作的眩晕、单侧感音性听力损失(SNHI)、耳鸣、耳闷为特征的慢性内耳障碍[2]。据统计，全世界每100万人中就有200～500人患有此病[3]。尤其是发病时眩晕的感觉使正常人难以忍受，严重影响了患者的生活质量。因此本文以PubMed数据库为依托，采用文献计量学方法分析近十年医学领域对该病的研究方向与研究热点，为医学工作者、科研工作者进行研究或立项工作提供参考。
1 材料与方法
1.1 检索方法 基于PubMed数据库，检索式为“Meniere Disease”[Mesh] AND (“2007/11/11”[PDat]：“2017/11/07”[PDat])，检索时间范围为2007年11月07-11日。, http://www.100md.com(唱得龙)
【关键词】 梅尼埃病； 文献计量学； 可视化； 研究热点
, http://www.100md.com Biclustering Analysis of Meniere Disease Research Based on Pubmed Database/CHANG Delong.//Medical Innovation of China，2018，15(01)：136-139
【Abstract】 Objective：To explore and analysis the hotspots of Meniere Disease in recently ten years.Method：The PubMed database was selected “Meniere Disease”[Mesh] AND (“2007/11/11”[PDat]：“2017/11/07”[PDat]).The results were retrieved by bibliographic information mining system (BICOMS) software，and gCLUTO 2.1 software was used for biclustering analysis and visualization analysis.Result：A total of 1084 literatures were retrieved， and the statistical analysis was divided into eight topics：intratympanic gentamicin can effectively control the vertigo that was caused by medically refractory unilateral Meniere disease；endolymphatic hydrops was a characteristic pathological manifestation of Meniere disease；the relationship between vestibular dysfunction and psychiatric disorders；evaluation of inner ear function by inducing vestibular evoked myogenic potential(VEMP)；endolymphatic sac surgery was effective in reducing the incidence and severity of vertigo attacks；the degree of endolymphatic hydrops affects the degree of hearing impairment；vestibular dysfunction causes other diseases；cVEMP can be used as a diagnostic test to differentiate Meniere disease from vestibular migraine.Conclusion：The biclustering analysis method is a good example of the current research direction on Meniere disease.
, 百拇医药
【Key words】 Meniere disease； Bibliometrics； Visualization； Research hotspots
First-author’s address：The Chinese People’s Liberation Army 463 Hospital，Shenyang 110000，China
doi：10.3969/j.issn.1674-4985.2018.01.038
梅尼埃病(Meniere Disease，MD)的最早報道要追溯至1861年，由法国医生Meniere所描述，他认为该病的本质是患者内耳功能紊乱，并伴随出现眩晕、听见异常声音和听力逐渐下降等情况[1]。现代医学权威机构前庭疾病分类委员会将MD定义为以反复自发性发作的眩晕、单侧感音性听力损失(SNHI)、耳鸣、耳闷为特征的慢性内耳障碍[2]。据统计，全世界每100万人中就有200～500人患有此病[3]。尤其是发病时眩晕的感觉使正常人难以忍受，严重影响了患者的生活质量。因此本文以PubMed数据库为依托，采用文献计量学方法分析近十年医学领域对该病的研究方向与研究热点，为医学工作者、科研工作者进行研究或立项工作提供参考。
1 材料与方法
1.1 检索方法 基于PubMed数据库，检索式为“Meniere Disease”[Mesh] AND (“2007/11/11”[PDat]：“2017/11/07”[PDat])，检索时间范围为2007年11月07-11日。, http://www.100md.com(唱得龙)