HIF—1α与TLR4在鼻息肉组织中的表达及相互关系(3)
HIF-1α与TLR4在鼻黏膜息肉病变发生机制上的研究仍尚不明朗。笔者采用Pearson相关性分析发现鼻息肉组织中HIF-1α、TLR4表达呈高度正相关性(r=0.907，P<0.01)。之前有研究证实当抑制鼻息肉组织TLR4表达后，HIF-1α的靶向产物表达受抑制[22]。结合本次研究结果可以推测出HIF-1α与TLR4之间可能存在交叉对话，它们共同促进了鼻息肉的形成与发展，但具体机制尚待进一步研究证明。
参考文献
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, http://www.100md.com
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, http://www.100md.com
[7] Semenza G L，Agani F，Booth G，et al.Structural and functional analysis of hypoxia-inducible factor 1[J].Kidney Int，1997，51(2)：553-555.
[8] Wang G L，Jiang B H，Rue E A，et al.Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O tension[J].Proc Natl Acad Sci USA，1995，92(12)：5510-5514.
[9] Tos M，Sasaki Y，Ohnishi M，et al.Pathogenesis of nasal polyps[J].Rhinol Suppl，1992，14：181-185.
, 百拇医药
[10] Chien C Y，Tai C F，Ho K Y，et al.Expression of hypoxia-inducible factor 1 in the nasal polyps by real-time RT-PCR and immunohistochemistry[J].Otolaryngology-Head and Neck Surgery，2008，139(2)：206-210.
[11] Filippi I，Morena E，Aldinucci C，et al.Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α
and PI3K/Akt pathway[J].J Cell Physiol，2014，229(12)：2067-2076.
[12] Zheng Z，Li Z，Chen S，et al.Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells：Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways[J].Exp Cell Res，2013，319(14)：2145-2151.
, http://www.100md.com
[13] Chern C M，Liou K T，Wang Y H，et al.Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury[J].Planta Med，2011，77(15)：1669-1679.
[14] Jeon W Y，Shin I S，Shin H K，et al.Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice[J].BMC Complement Altern Med，2015，15(1)：47., 百拇医药(崔粲 任金龙 王银霞)
参考文献
[1] Larsen P L，Tos M.Nasal polyps：epithelium and goblet cell density[J].Laryngoscope，1989，99(12)：1274-1280.
[2] Shin H W，Cho K，Kim D W，et al.Hypoxia-inducible Factor 1 Mediates Nasal Polypogenesis by Inducing Epithelial-to-Mesenchymal Transition[J].Am J Respir Crit Care Med，2012，185(9)：944-954.
, http://www.100md.com
[3] Bachert C，Zele T，Gevaert P，et al.Super antigens and nasal polyps[J].Curr Allergy Asthma Rep，2003，3(6)：523-531.
[4]王成碩，董震，杨占泉.Toll样受体mRNA在鼻息肉中的表达及意义[J].中国耳鼻咽喉头颈外科，2004，11(3)：185-187.
[5] Bracken C P，Whitelaw M L，Peet D J.The hypoxia-inducible factors：key transcriptional regulators of hypoxic responses[J].Cell Mol Life Sci，2003，60：1376-1393.
[6] Moynagh PN.Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids[J].J En docrinol，2003，179(2)：139-144.
, http://www.100md.com
[7] Semenza G L，Agani F，Booth G，et al.Structural and functional analysis of hypoxia-inducible factor 1[J].Kidney Int，1997，51(2)：553-555.
[8] Wang G L，Jiang B H，Rue E A，et al.Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O tension[J].Proc Natl Acad Sci USA，1995，92(12)：5510-5514.
[9] Tos M，Sasaki Y，Ohnishi M，et al.Pathogenesis of nasal polyps[J].Rhinol Suppl，1992，14：181-185.
, 百拇医药
[10] Chien C Y，Tai C F，Ho K Y，et al.Expression of hypoxia-inducible factor 1 in the nasal polyps by real-time RT-PCR and immunohistochemistry[J].Otolaryngology-Head and Neck Surgery，2008，139(2)：206-210.
[11] Filippi I，Morena E，Aldinucci C，et al.Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α
and PI3K/Akt pathway[J].J Cell Physiol，2014，229(12)：2067-2076.
[12] Zheng Z，Li Z，Chen S，et al.Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells：Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways[J].Exp Cell Res，2013，319(14)：2145-2151.
, http://www.100md.com
[13] Chern C M，Liou K T，Wang Y H，et al.Andrographolide inhibits PI3K/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia/ischemia-induced oxidative brain injury[J].Planta Med，2011，77(15)：1669-1679.
[14] Jeon W Y，Shin I S，Shin H K，et al.Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice[J].BMC Complement Altern Med，2015，15(1)：47., 百拇医药(崔粲 任金龙 王银霞)
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