血清G—CSF和IL—11与急性淋巴细胞白血病大剂量化疗感染和出血的关系分析(1)
【摘要】 目的：探讨血清粒系集落刺激因子(Granulocyte colony-stimulating factor，G-CSF)和白介素11(Interleukin 11，IL-11)与急性淋巴细胞白血病大剂量化疗感染和出血的关系。方法：选取2015年1月-2017年1月本院急性淋巴细胞白血病患者32例，患者均行大剂量甲氨蝶呤化疗，3个月为一疗程，共治疗3个疗程。比较患者治疗前后的血清G-CSF和IL-11水平，统计化疗期间和化疗后1个月内患者感染和出血情况，分析患者血清G-CSF和IL-11水平与其感染率和出血率的关系。结果：患者治疗后的血清G-CSF和IL-11水平均高于治疗前，比较差异均有统计学意义(P<0.05)。32例患者在化疗期间和化疗1个月内感染率为37.50%(12/32)，出血率为50.00%(16/32)。未感染患者化疗前后的血清G-CSF和IL-11水平均高于感染患者(P<0.05)；未出血患者化疗前后的血清G-CSF和IL-11水平均高于出血患者(P<0.05)。Spearman无条件相关分析结果显示，化疗后患者血清G-CSF与其感染率和出血率均呈负相关(r=-0.892、-0.815，P=0.000、0.002)；化疗后IL-11水平与其感染率和出血率均呈负相关(r=-0.793、-0.762，P=0.013、0.018)。结论：急性淋巴细胞白血病大剂量化疗后患者血清G-CSF和IL-11水平與其感染和出血的发生密切相关，可作为其感染和出血评估的参考指标。
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【关键词】 粒系集落刺激因子； 白介素11； 急性淋巴细胞白血病； 大剂量化疗； 感染；
出血； 关系
【Abstract】 Objective：To investigate the relationship between serum granulocyte colony-stimulating factor(G-CSF) and interleukin 11(IL-11) and high-dose chemotherapy infection and hemorrhage in acute lymphoblastic leukemia.Method：A total of 32 patients with acute lymphoblastic leukemia in our hospital from January 2015 to January 2017 were selected，they were treated with high dose methotrexate chemotherapy，3 months for every course and they were treated for 3 courses.The levels of serum G-CSF and IL-11 before and after treatment were compared，the infection and bleeding of patients during and after 1 month of chemotherapy were statistically analyzed，the relationship between the levels of serum G-CSF and IL-11 and the rate of infection and bleeding was analyzed.Result：The levels of serum G-CSF and IL-11 after treatment were higher than those of before treatment，the difference was statistically significant(P<0.05).In 32 patients，the infection rate was 37.50%(12/32) and the bleeding rate was 50.00%(16/32) during the chemotherapy and 1 month of chemotherapy.The levels of serum G-CSF and IL-11 in uninfected patients before and after chemotherapy were higher than those of infected patients(P<0.05)，the levels of serum G-CSF and IL-11 in non bleeding patients before and after chemotherapy were higher than those of bleeding patients(P<0.05).Spearman unconditional correlation analysis showed that，after chemotherapy，there was a negative correlation between serum G-CSF and infection rate and bleeding rate(r=-0.892，-0.815，P=0.000，0.002)，IL-11 was negatively correlated with infection rate and bleeding rate(r=-0.793，-0.762，P=0.013，0.018).Conclusion：The levels of serum G-CSF and IL-11 in patients with high-dose chemotherapy in acute lymphoblastic leukemia is closely related to the incidence of infection and bleeding，can be used as a reference index for the assessment of infection and bleeding., 百拇医药(梁月雄 黄鹏程 李冰)
, http://www.100md.com
【关键词】 粒系集落刺激因子； 白介素11； 急性淋巴细胞白血病； 大剂量化疗； 感染；
出血； 关系
【Abstract】 Objective：To investigate the relationship between serum granulocyte colony-stimulating factor(G-CSF) and interleukin 11(IL-11) and high-dose chemotherapy infection and hemorrhage in acute lymphoblastic leukemia.Method：A total of 32 patients with acute lymphoblastic leukemia in our hospital from January 2015 to January 2017 were selected，they were treated with high dose methotrexate chemotherapy，3 months for every course and they were treated for 3 courses.The levels of serum G-CSF and IL-11 before and after treatment were compared，the infection and bleeding of patients during and after 1 month of chemotherapy were statistically analyzed，the relationship between the levels of serum G-CSF and IL-11 and the rate of infection and bleeding was analyzed.Result：The levels of serum G-CSF and IL-11 after treatment were higher than those of before treatment，the difference was statistically significant(P<0.05).In 32 patients，the infection rate was 37.50%(12/32) and the bleeding rate was 50.00%(16/32) during the chemotherapy and 1 month of chemotherapy.The levels of serum G-CSF and IL-11 in uninfected patients before and after chemotherapy were higher than those of infected patients(P<0.05)，the levels of serum G-CSF and IL-11 in non bleeding patients before and after chemotherapy were higher than those of bleeding patients(P<0.05).Spearman unconditional correlation analysis showed that，after chemotherapy，there was a negative correlation between serum G-CSF and infection rate and bleeding rate(r=-0.892，-0.815，P=0.000，0.002)，IL-11 was negatively correlated with infection rate and bleeding rate(r=-0.793，-0.762，P=0.013，0.018).Conclusion：The levels of serum G-CSF and IL-11 in patients with high-dose chemotherapy in acute lymphoblastic leukemia is closely related to the incidence of infection and bleeding，can be used as a reference index for the assessment of infection and bleeding., 百拇医药(梁月雄 黄鹏程 李冰)