注射用七叶皂苷钠对慢性鼻—鼻窦炎术后黏膜恢复的影响(1)
【摘要】 目的：觀察注射用七叶皂苷钠对慢性鼻-鼻窦炎患者术后临床症状、体征及鼻腔、窦腔黏膜上皮变化的影响。方法：选择本院2015年7月-2016年6月收治的慢性鼻窦炎患者80例，按照随机数字表法将患者分为试验组和对照组，各40例。试验组在常规术后治疗的基础上静脉滴注七叶皂苷钠，对照组在常规术后治疗的基础上静脉滴注地塞米松。两组均根据术区恢复情况制定个性化定期复查，随诊3个月。结果：试验组填塞物抽出后鼻腔出血情况明显优于对照组，差异有统计学意义(Z=-2.785，P=0.005)；试验组抽出填塞物后3 d黏膜水肿情况明显轻于对照组，差异有统计学意义(P<0.05)；试验组鼻黏膜水肿平均消退时间短于对照组，差异有统计学意义(Z=-2.959，P=0.003)；试验组无症状例数明显多于对照组，差异有统计学意义( 字2=5.591，P=0.018)；试验组治愈率明显高于对照组，差异有统计学意义( 字2=4.588，P=0.032)，但两组的总有效率比较，差异无统计学意义(P>0.05)。结论：在慢性鼻-鼻窦炎术后常规治疗的基础上加用七叶皂苷钠，可减少鼻腔粘连、出血，减轻黏膜炎性反应和水肿，缩短水肿消退时间，促进术腔上皮化，明显提高疗效。
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【关键词】 七叶皂苷钠； 鼻窦炎； 鼻黏膜
The Effect of Sodium Aescinate for Injection on the Recovery of Nasal Mucous after the Operation of Chronic Rhinosinusitis/ZUO Hongwei，ZHOU Rongrong，ZHAO Limin，et al.//Medical Innovation of China，2018，15(03)：032-035
【Abstract】 Objective：To observe the effect of the Sodium Aescinate for Injection on the symptoms，signs and the changes of nasal mucosa in patients with chronic nasal sinusitis after endoscopic sinus surgery.Method：From July 2015 to June 2016，80 patients with chronic sinustis admitted into our hospital were selected，patients were divided into experimental group and control group，40 cases in each group.The experimental group was treated with intravenous infusion of Sodium Aescinate for Injection on the basis of routine postoperative treatment，the control group was treated with intravenous drip of Dexamethasone on the basis of routine postoperative treatment.According to the recovery of the two groups，the individual periodic reexamination was made，and the follow-up was 3 months.Result：The hemorrhage of the nasal cavity in the experimental group was significantly better than that of the control group， the difference was statistically significant(Z=-2.785，P=0.005)；the 3 d mucous membrane edema in the experimental group was significantly lighter than that in the control group，the difference was statistically significant(Z=-2.959，P=0.003)；the average regression time of nasal edema in the experimental group was shorter than that in the control group，the difference was statistically significant(P<0.05)；the number of asymptomatic cases in the experimental group was obviously more than that of the control group，the difference was statistically significant( 字2=5.591，P=0.018)；the cure rate of the experimental group was significantly higher than that of the control group，the difference was statistically significant( 字2=4.588，P=0.032)，but there was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion：Sodium Aescinate for Injection is added on the basis of conventional treatment for chronic rhinosinusitis，it can reduce nasal adhesion，bleeding，relieve mucous inflammatory reaction and edema，shorten the time of edema and decline，promote the epithelialization of the operation cavity，and improve the curative effect obviously., http://www.100md.com(左红伟 周荣荣 赵立民)
, http://www.100md.com
【关键词】 七叶皂苷钠； 鼻窦炎； 鼻黏膜
The Effect of Sodium Aescinate for Injection on the Recovery of Nasal Mucous after the Operation of Chronic Rhinosinusitis/ZUO Hongwei，ZHOU Rongrong，ZHAO Limin，et al.//Medical Innovation of China，2018，15(03)：032-035
【Abstract】 Objective：To observe the effect of the Sodium Aescinate for Injection on the symptoms，signs and the changes of nasal mucosa in patients with chronic nasal sinusitis after endoscopic sinus surgery.Method：From July 2015 to June 2016，80 patients with chronic sinustis admitted into our hospital were selected，patients were divided into experimental group and control group，40 cases in each group.The experimental group was treated with intravenous infusion of Sodium Aescinate for Injection on the basis of routine postoperative treatment，the control group was treated with intravenous drip of Dexamethasone on the basis of routine postoperative treatment.According to the recovery of the two groups，the individual periodic reexamination was made，and the follow-up was 3 months.Result：The hemorrhage of the nasal cavity in the experimental group was significantly better than that of the control group， the difference was statistically significant(Z=-2.785，P=0.005)；the 3 d mucous membrane edema in the experimental group was significantly lighter than that in the control group，the difference was statistically significant(Z=-2.959，P=0.003)；the average regression time of nasal edema in the experimental group was shorter than that in the control group，the difference was statistically significant(P<0.05)；the number of asymptomatic cases in the experimental group was obviously more than that of the control group，the difference was statistically significant( 字2=5.591，P=0.018)；the cure rate of the experimental group was significantly higher than that of the control group，the difference was statistically significant( 字2=4.588，P=0.032)，but there was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion：Sodium Aescinate for Injection is added on the basis of conventional treatment for chronic rhinosinusitis，it can reduce nasal adhesion，bleeding，relieve mucous inflammatory reaction and edema，shorten the time of edema and decline，promote the epithelialization of the operation cavity，and improve the curative effect obviously., http://www.100md.com(左红伟 周荣荣 赵立民)