重度子痫前期合并胎儿生长受限孕妇妊娠晚期血清氧化蛋白产物和胱抑素C水平表达及其临床意义(1)
【摘要】 目的：探討重度子痫前期合并胎儿生长受限孕妇妊娠晚期血清氧化蛋白产物(Advanced oxidation protein products，AOPP)和胱抑素C(Cystatin C，Cys-C)水平表达及其临床意义。方法：选取2015年6月-2016年12月就诊本院的重度子痫前期合并胎儿受限的孕妇40例设为研究组，根据预后情况分为预后不良组(28例)和预后良好组(12例)，同期选取40例正常晚期妊娠的孕妇为对照组，采用免疫散射浊度法、免疫比浊法检测所有研究对象血清Cys-C和AOPP，比较研究组和对照组血清AOPP和Cys-C表达水平，并分析两者表达水平预测预后情况的临床价值。结果：研究组血清AOPP和Cys-C水平均高于对照组，差异均有统计学意义(P<0.05)；预后不良组血清AOPP和Cys-C水平均高于预后良好组，差异均有统计学意义(P<0.05)；经Spearman相关性分析，血清AOPP和Cys-C水平与预后情况呈一定相关性(r=0.721 541，P<0.05)；ROC曲线分析显示，血清AOPP和Cys-C水平预测重度子痫前期及胎儿生长受限孕妇预后具有良好的评估价值。结论：重度子痫前期及胎儿生长受限孕妇妊娠晚期血清AOPP和Cys-C水平明显升高，且AOPP和Cys-C水平与患者的妊娠结局有着重要的相关性，提示动态监测两者变化趋势有助于评估预后。
, http://www.100md.com
【关键词】 重度子痫前期； 胎儿生长受限； 氧化蛋白产物； 胱抑素C
【Abstract】 Objective：To discuss the expression and significance of serum serum cystatin C and AOPP in severe preeclampsia in combination with fetal growth restriction.Method：40 patients with severe preeclampsia in combination with fetal growth restriction from June 2015 to December 2016 were selected and assigned as research group， according to the prognosis they were devided into poor prognosis group (28 cases) and good prognosis group (12 cases).In the same period， 40 pregnant women with normal late pregnancy were selected and assigned as control group. The serum Cys-C and AOPP of all subjects were detected by immunoassay and turbidimetric method.The serum AOPP and Cys-C expression levels in the research group and the control group were compared.The clinical value of predicting the prognosis of the two groups were analyzed.Result：Serum AOPP and Cys-C levels in research group were higher than those of control group， the differences were statistically significant(P<0.05). Serum AOPP and Cys-C levels of poor prognosis group were higher than those of good prognosis group， the differences were statistically significant(P<0.05).According to Spearman correlation analysis， serum AOPP and Cys-C levels were correlated with prognostic conditions (r=0.721 541，P<0.05).ROC curve analysis showed that the serum AOPP and Cys-C levels predicted the prognosis of pregnant women with severe preeclampsia in combination with fetal growth restriction had good evaluation value.Conclusion：The serum AOPP and Cys-C levels of severe preeclampsia in combination with fetal growth restriction women in the second trimester is higher than normal pregnant women，which is related to genesis of preeclampsia and adverse pregnant outcomes.
【Key words】 Severe preeclampsia； Fetal growth restriction； AOPP； Cys-C
First-author’s address：Shajing People’s Hospital，Shenzhen 518104，China, 百拇医药(韩静 初晓丽 方渝 温华生 蔡淑媛 华建江)
, http://www.100md.com
【关键词】 重度子痫前期； 胎儿生长受限； 氧化蛋白产物； 胱抑素C
【Abstract】 Objective：To discuss the expression and significance of serum serum cystatin C and AOPP in severe preeclampsia in combination with fetal growth restriction.Method：40 patients with severe preeclampsia in combination with fetal growth restriction from June 2015 to December 2016 were selected and assigned as research group， according to the prognosis they were devided into poor prognosis group (28 cases) and good prognosis group (12 cases).In the same period， 40 pregnant women with normal late pregnancy were selected and assigned as control group. The serum Cys-C and AOPP of all subjects were detected by immunoassay and turbidimetric method.The serum AOPP and Cys-C expression levels in the research group and the control group were compared.The clinical value of predicting the prognosis of the two groups were analyzed.Result：Serum AOPP and Cys-C levels in research group were higher than those of control group， the differences were statistically significant(P<0.05). Serum AOPP and Cys-C levels of poor prognosis group were higher than those of good prognosis group， the differences were statistically significant(P<0.05).According to Spearman correlation analysis， serum AOPP and Cys-C levels were correlated with prognostic conditions (r=0.721 541，P<0.05).ROC curve analysis showed that the serum AOPP and Cys-C levels predicted the prognosis of pregnant women with severe preeclampsia in combination with fetal growth restriction had good evaluation value.Conclusion：The serum AOPP and Cys-C levels of severe preeclampsia in combination with fetal growth restriction women in the second trimester is higher than normal pregnant women，which is related to genesis of preeclampsia and adverse pregnant outcomes.
【Key words】 Severe preeclampsia； Fetal growth restriction； AOPP； Cys-C
First-author’s address：Shajing People’s Hospital，Shenzhen 518104，China, 百拇医药(韩静 初晓丽 方渝 温华生 蔡淑媛 华建江)
参见：首页 > 保健版 > 家庭健康 > 女性保健 > 孕育新生命 > 胎儿知识