和厚朴酚抗头颈部肿瘤作用的研究进展(3)
3.5 HNK与头颈部其他肿瘤 研究还发现，HNK对口腔癌HN22细胞[28]、舌癌SOC-19细胞、喉癌SCC-5细胞、头颈部肿瘤Cal-33细胞等多种头颈部肿瘤细胞同样有抑制增殖作用。另外，HNK在体内外可增强部分头颈部肿瘤化疗的敏感性。如在体外，HNK增强厄洛替尼对耐药型及敏感型头颈部肿瘤686LN细胞增殖的抑制作用；在体内，西妥昔单抗抑制移植于裸鼠的头颈部鳞癌1483细胞的生长作用，通过HNK也可得到加强，可能与降低EGFR、相关通路因子p-STAT3和cyclin D的表达有关[15]。
头颈部肿瘤是一种常见的肿瘤，其治疗中相关的副作用给患者带来不小的痛苦，因而寻找有效、低毒的药物是刻不容缓的。我国中草药HNK的抗肿瘤作用在国内外普遍研究，随着研究的逐漸深入，了解HNK的抗头颈部肿瘤细胞的研究进展对药物尽早应用于临床奠定了基础，为其研究新的抗肿瘤作用铺路。综上所述，HNK可作为诊治头颈部肿瘤的候选药物之一，具有很大的研究和临床应用价值。
参考文献
, http://www.100md.com
[1] Yang J，Wu W，Wen J，et al.Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells[J].Biomaterials，2017，141：188-198.
[2] Liu R X，Ren W Y，Ma Y，et al.BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells[J].Int J Oncol，2017，51(3)：907-917.
[3] Balan M，Chakraborty S，Flynn E，et al.Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth[J].Scientific Reports，2017，7(1)：1-11.
, 百拇医药
[4] Avtanski D B，Nagalingam A，Bonner M Y，et al.Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis[J].Molecular Oncology，2014，8(3)：565-580.
[5] Shen L，Zhang F，Huang R，et al.Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition[J].Oncol Lett，2017，14(4)：4294-4300.
, http://www.100md.com
[6] Hahm E R，Singh K B，Singh S V.c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells[J].Cell Cycle，2016，15(17)：2309-2320.
[7] Prasad R，Kappes J C，Katiyar S K.Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells[J].Oncotarget，2016，7(7)：7899.
[8] Prasad R，Singh T，Katiyar S K.Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin[J].Scientific Reports，2017，7(1)：1657.
, 百拇医药
[9] Zhou B，Li H，Xing C，et al.Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia[J].Biochemical Pharmacology，2017，128：12-25.
[10] Arora S，Singh S，Piazza G A，et al.Honokiol：A Novel Natural Agent for Cancer Prevention and Therapy[J].Current Molecular Medicine，2012，2(10)：1244-1252., 百拇医药(李姣 姚俊)
头颈部肿瘤是一种常见的肿瘤，其治疗中相关的副作用给患者带来不小的痛苦，因而寻找有效、低毒的药物是刻不容缓的。我国中草药HNK的抗肿瘤作用在国内外普遍研究，随着研究的逐漸深入，了解HNK的抗头颈部肿瘤细胞的研究进展对药物尽早应用于临床奠定了基础，为其研究新的抗肿瘤作用铺路。综上所述，HNK可作为诊治头颈部肿瘤的候选药物之一，具有很大的研究和临床应用价值。
参考文献
, http://www.100md.com
[1] Yang J，Wu W，Wen J，et al.Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells[J].Biomaterials，2017，141：188-198.
[2] Liu R X，Ren W Y，Ma Y，et al.BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells[J].Int J Oncol，2017，51(3)：907-917.
[3] Balan M，Chakraborty S，Flynn E，et al.Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth[J].Scientific Reports，2017，7(1)：1-11.
, 百拇医药
[4] Avtanski D B，Nagalingam A，Bonner M Y，et al.Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis[J].Molecular Oncology，2014，8(3)：565-580.
[5] Shen L，Zhang F，Huang R，et al.Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition[J].Oncol Lett，2017，14(4)：4294-4300.
, http://www.100md.com
[6] Hahm E R，Singh K B，Singh S V.c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells[J].Cell Cycle，2016，15(17)：2309-2320.
[7] Prasad R，Kappes J C，Katiyar S K.Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells[J].Oncotarget，2016，7(7)：7899.
[8] Prasad R，Singh T，Katiyar S K.Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin[J].Scientific Reports，2017，7(1)：1657.
, 百拇医药
[9] Zhou B，Li H，Xing C，et al.Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia[J].Biochemical Pharmacology，2017，128：12-25.
[10] Arora S，Singh S，Piazza G A，et al.Honokiol：A Novel Natural Agent for Cancer Prevention and Therapy[J].Current Molecular Medicine，2012，2(10)：1244-1252., 百拇医药(李姣 姚俊)
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