二甲双胍治疗糖尿病合并肺结核短期临床疗效观察(1)
【摘要】 目的：觀察二甲双胍治疗糖尿病合并肺结核的短期临床疗效。方法：收集本院2016年1月-2017年6月收治的90例2型糖尿病合并肺结核初治涂阳患者，按照不同降糖方案分为观察组、对照1组和对照2组，每组30例。观察组给予二甲双胍+甘精胰岛素+门冬胰岛素降糖治疗，对照1组给予甘精胰岛素+门冬胰岛素降糖治疗，对照2组给予口服药物治疗(二联或三联，二甲双胍联合阿卡波糖或格列齐特或格列美脲)降血糖。三组抗结核均为3HRZE方案。治疗周期均为3个月。结果：治疗后，观察组、对照1组治疗后的空腹血糖及糖化血红蛋白均低于对照2组，差异均有统计学意义(P<0.05)。观察组空腹血糖及糖化血红蛋与对照1组比较，差异无统计学意义(P>0.05)。观察组、对照组1组痰菌转阴率及病灶吸收有效率均高于对照2组，比较差异均有统计学意义(P<0.05)。观察组痰菌转阴率及病灶吸收有效率高于对照1组，比较差异均无统计学意义(P>0.05)。结论：2型糖尿病合并肺结核患者首选胰岛素治疗，二甲双胍联合胰岛素治疗可提高2型糖尿病合并肺结核初治患者的痰菌转阴率及病灶吸收率。
, 百拇医药
【关键词】 二甲双胍； 2型糖尿病； 肺结核
Observation on Short-term Clinical Efficacy of Metformin in Treatment of Diabetes Mellitus Combined with Tuberculosis/ZHANG Ying，ZHU Huimin，FU Liang，et al.//Medical Innovation of China，2018，15(13)：035-037
【Abstract】 Objective：To evaluate the short-term clinical efficacy of Metformin in the treatment of diabetes mellitus combined with tuberculosis.Method：A total of 90 cases with type 2 diabetes mellitus and initial smear-positive tuberculosis patients in our hospital from January 2016 to June 2017 were divided into observation group，control group 1 and control group 2，30 cases in each group.The observation group was treated by Metformin+Insulin Glargine+Insulin Aspart，the control group 1 was treated by Insulin Glargine+Insulin Aspart，the control group 2 was treated by oral medication(duplex or triplex，Metformin combined with Acarbose or Gliclazide or Glimepiride).Three groups were treated by 3HRZE antituberculosis therapy.The treatment period was 3 months.Result：After treatment，the fasting blood glucose and glycosylated hemoglobin of the observation group and the control group 1 were lower than those of the control group 2，the differences were statistically significant(P<0.05).There were no statistically significant at the fasting blood glucose and glycosylated hemoglobin of the observation group and the control group 1(P>0.05).The sputum bacteria negative conversion ratio and lesions absorption effective rate of the observation group and the control group 1 were higher than those of the control group 2，the differences were statistically significant(P<0.05).The sputum bacteria negative conversion ratio and lesions absorption effective rate of the observation group were higher than those of the control group 1，but the differences were no statistically significant(P>0.05).Conclusion：The patients with type 2 diabetes mellitus and tuberculosis first choice are insulin therapy.The treatment of Metformin in combination with Insulin therapy can improve the sputum bacteria negative conversion ratio and lesions absorption effective rate of the patients with type 2 diabetes mellitus and tuberculosis., 百拇医药(张颖 朱惠敏 付亮 蒋静 吴嘉)
, 百拇医药
【关键词】 二甲双胍； 2型糖尿病； 肺结核
Observation on Short-term Clinical Efficacy of Metformin in Treatment of Diabetes Mellitus Combined with Tuberculosis/ZHANG Ying，ZHU Huimin，FU Liang，et al.//Medical Innovation of China，2018，15(13)：035-037
【Abstract】 Objective：To evaluate the short-term clinical efficacy of Metformin in the treatment of diabetes mellitus combined with tuberculosis.Method：A total of 90 cases with type 2 diabetes mellitus and initial smear-positive tuberculosis patients in our hospital from January 2016 to June 2017 were divided into observation group，control group 1 and control group 2，30 cases in each group.The observation group was treated by Metformin+Insulin Glargine+Insulin Aspart，the control group 1 was treated by Insulin Glargine+Insulin Aspart，the control group 2 was treated by oral medication(duplex or triplex，Metformin combined with Acarbose or Gliclazide or Glimepiride).Three groups were treated by 3HRZE antituberculosis therapy.The treatment period was 3 months.Result：After treatment，the fasting blood glucose and glycosylated hemoglobin of the observation group and the control group 1 were lower than those of the control group 2，the differences were statistically significant(P<0.05).There were no statistically significant at the fasting blood glucose and glycosylated hemoglobin of the observation group and the control group 1(P>0.05).The sputum bacteria negative conversion ratio and lesions absorption effective rate of the observation group and the control group 1 were higher than those of the control group 2，the differences were statistically significant(P<0.05).The sputum bacteria negative conversion ratio and lesions absorption effective rate of the observation group were higher than those of the control group 1，but the differences were no statistically significant(P>0.05).Conclusion：The patients with type 2 diabetes mellitus and tuberculosis first choice are insulin therapy.The treatment of Metformin in combination with Insulin therapy can improve the sputum bacteria negative conversion ratio and lesions absorption effective rate of the patients with type 2 diabetes mellitus and tuberculosis., 百拇医药(张颖 朱惠敏 付亮 蒋静 吴嘉)