中国医学创新目次维格列汀辅助治疗多囊卵巢综合征并糖代谢异常的效果(1)
【摘要】 目的：探討维格列汀辅助二甲双胍治疗多囊卵巢综合征(PCOS)合并糖代谢异常患者的临床效果，为临床治疗提供依据。方法：选取2016年4月-2017年8月笔者所在医院收治的PCOS并糖代谢异常患者80例。按照随机数表法将其分为试验组与对照组，各40例。对照组给予二甲双胍治疗，试验组在此基础上给予维格列辅助治疗，两组均干预治疗6个月。比较两组治疗前后内分泌指标(FSH、PRL、E2、LH、T、P、A)、糖代谢(FPG、2 h PG、HbA1c)和脂代谢(TC、TG、HDL-C、LDL-C)水平。结果：治疗后，试验组T、TG、LDL-C水平均低于治疗前及对照组，比较差异均有统计学意义(P<0.05)，但其他指标组间及组内比较差异均无统计学意义(P>0.05)；治疗后，两组FPG、2 h PG、HbA1c水平均低于治疗前，且试验组均低于对照组，比较差异均有统计学意义(P<0.05)。结论：维格列汀辅助二甲双胍治疗PCOS合并糖代谢异常患者，能够显著改善患者内分泌水平，调和糖、脂代谢异常情况，在临床上具有较高的应用价值。
【关键词】 多囊卵巢综合征； 维格列汀； 二甲双胍； 糖代谢异常
, 百拇医药
Effect of Vildagliptin on Adjuvant Treatment of Polycystic Ovary Syndrome with Abnormal Glucose Metabolism/CHEN Yu，CHEN Jiehui，WU Qiuhua，et al.//Medical Innovation of China，2018，15(14)：051-054
【Abstract】 Objective：To investigate the clinical effect of Vildagliptin on adjuvant treatment of polycystic ovary syndrome(PCOS) with abnormal glucose metabolism，and to provide basis for clinical treatment.Method：A total of 80 PCOS patients with abnormal glucose metabolism were treated in author’s hospital from April 2016 to August 2017 were selected.According to the random number table method，they were divided into experimental group and control group，40 cases in each group.The control group was given metformin treatment，and experimental group was treated with Vildagliptin on basis of control group，they were treated for 6 months.The levels of endocrine indicators(FSH，PRL，E2，LH，T，P，A)，sugar metabolism(FPG，2 h PG，HbA1c) and lipid metabolism(TC，TG，HDL-C，LDL-C) before and after treatment in two groups were compared.Result：After treatment，the levels of T，TG and LDL-C in experimental group were lower than those before treatment and control group，the differences were statistically significant(P<0.05)，but the inter group and intra group comparison of other indicators，the differences were not statistically significant(P>0.05).After treatment，the levels of FPG，2 h PG and HbA1c in two groups were all lower than those before treatment，and experimental group were lower than those of control group，the differences were statistically significant(P<0.05).Conclusion：Vitaloglidine-assisted metformin in PCOS patients with abnormal glucose metabolism can significantly improve the patient’s endocrine levels，to reconcile the abnormalities of glucose and lipid metabolism，has a high clinical value.
【Key words】 Polycystic ovary syndrome； Vildagliptin； Metformin； Abnormal glucose metabolism
First-author’s address：Huizhou Central People’s Hospital，Huizhou 516000，China, 百拇医药(陈誉 陈洁慧 吴秋华)
【关键词】 多囊卵巢综合征； 维格列汀； 二甲双胍； 糖代谢异常
, 百拇医药
Effect of Vildagliptin on Adjuvant Treatment of Polycystic Ovary Syndrome with Abnormal Glucose Metabolism/CHEN Yu，CHEN Jiehui，WU Qiuhua，et al.//Medical Innovation of China，2018，15(14)：051-054
【Abstract】 Objective：To investigate the clinical effect of Vildagliptin on adjuvant treatment of polycystic ovary syndrome(PCOS) with abnormal glucose metabolism，and to provide basis for clinical treatment.Method：A total of 80 PCOS patients with abnormal glucose metabolism were treated in author’s hospital from April 2016 to August 2017 were selected.According to the random number table method，they were divided into experimental group and control group，40 cases in each group.The control group was given metformin treatment，and experimental group was treated with Vildagliptin on basis of control group，they were treated for 6 months.The levels of endocrine indicators(FSH，PRL，E2，LH，T，P，A)，sugar metabolism(FPG，2 h PG，HbA1c) and lipid metabolism(TC，TG，HDL-C，LDL-C) before and after treatment in two groups were compared.Result：After treatment，the levels of T，TG and LDL-C in experimental group were lower than those before treatment and control group，the differences were statistically significant(P<0.05)，but the inter group and intra group comparison of other indicators，the differences were not statistically significant(P>0.05).After treatment，the levels of FPG，2 h PG and HbA1c in two groups were all lower than those before treatment，and experimental group were lower than those of control group，the differences were statistically significant(P<0.05).Conclusion：Vitaloglidine-assisted metformin in PCOS patients with abnormal glucose metabolism can significantly improve the patient’s endocrine levels，to reconcile the abnormalities of glucose and lipid metabolism，has a high clinical value.
【Key words】 Polycystic ovary syndrome； Vildagliptin； Metformin； Abnormal glucose metabolism
First-author’s address：Huizhou Central People’s Hospital，Huizhou 516000，China, 百拇医药(陈誉 陈洁慧 吴秋华)