新斯的明拮抗老年患者腹腔镜胆囊切除手术后顺式阿曲库铵残留阻滞作用的量效研究(1)
【摘要】 目的：探析新斯的明拮抗老年患者腹腔鏡胆囊切除手术后顺式阿曲库铵残留阻滞作用的量效。方法：选取本院2016年1月-2017年12月期间接受腹腔镜胆囊切除手术治疗的120例老年患者为观察对象，按照随机数字表法将其分为四组，即对照组(n=30)、观察1组(n=30)、观察2组(n=30)、观察3组(n=30)。在术后4个成串刺激比值(TOFR)恢复到0.5时，对照组给予生理盐水，观察1、2、3组给予新斯的明，剂量分别为5、10、20 ?g/kg，对各组TOFR恢复至1.0的时间、10 min内TOFR恢复至1.0的百分率及术后6 h恶心呕吐发生率进行记录比较。结果：观察3组TOFR恢复至1.0的时间均明显短于对照组与观察1、2组，10 min内TOFR恢复至1.0的百分率均明显高于对照组与观察1、2组，差异均有统计学意义(P<0.05)；而观察1、2组TOFR恢复至1.0的时间、10 min内TOFR恢复至1.0的百分率与对照组比较，差异均无统计学意义(P>0.05)。四组术后6 h恶心呕吐发生率比较，差异均无统计学意义(P>0.05)。结论：新斯的明拮抗老年患者腹腔镜胆囊切除手术后顺式阿曲库铵残留阻滞作用的量效十分显著，且安全、可靠。
, 百拇医药
【关键词】 腹腔镜胆囊切除术； 新斯的明； 顺式阿曲库铵； 残留阻滞作用
【Abstract】 Objective：To explore the dose-effect of Neostigmine antagonizing Cistracurium residual paralysis in elderly patients after laparoscopic cholecystectomy.Method：A total of 120 cases of elderly patients underwent surgical treatment of laparoscopic cholecystectomy in our hospital from January 2016 to December 2017 were selected as the observation objects.According to the random number table method，they were divided into four groups：the control group (n=30)，the observation group 1 (n=30)，the observation group 2 (n=30)，the observation group 3 (n=30).The control group was given normal saline，the observation group 1，2，3 were given 5，10，20 ?g/kg Neostigmine respectively，when Train-Of-Four-Ratio returned to 0.5 after surgery.The time TOFR to 1.0， the ratio of successful reversal within 10 min and postoperative nausea and vomiting after surgery 6 h of each group were compared.Result：The time TOFR to 1.0 in the observation group 3 was significantly shorter than those in the control group and the observation group 1，2；the ratio of successful reversal within 10 min was significantly higher than those of the control group and the observation group 1，2，the differences were statistically significant(P<0.05).There were no statistical differences in the time TOFR to 1.0 and the ratio of successful reversal within 10 min between the observation group 1，2 and the control group.There were no statistical differences in the incidence of nausea and vomiting after surgery 6 h(P>0.05).Conclusion：The dose-effect of Neostigmine antagonizing Cistracurium residual paralysis in elderly patients after laparoscopic cholecystectomy are significant and safe and reliable.
【Key words】 Laparoscopic cholecystectomy； Neostigmine； Cistracurium； Residual Paralysis effect
First-author’s address：The Second People’s Hospital of Shenzhen， Shenzhen 518035，China
doi：10.3969/j.issn.1674-4985.2018.15.012, http://www.100md.com(史嘉华 陈志聪 陈剑明)
, 百拇医药
【关键词】 腹腔镜胆囊切除术； 新斯的明； 顺式阿曲库铵； 残留阻滞作用
【Abstract】 Objective：To explore the dose-effect of Neostigmine antagonizing Cistracurium residual paralysis in elderly patients after laparoscopic cholecystectomy.Method：A total of 120 cases of elderly patients underwent surgical treatment of laparoscopic cholecystectomy in our hospital from January 2016 to December 2017 were selected as the observation objects.According to the random number table method，they were divided into four groups：the control group (n=30)，the observation group 1 (n=30)，the observation group 2 (n=30)，the observation group 3 (n=30).The control group was given normal saline，the observation group 1，2，3 were given 5，10，20 ?g/kg Neostigmine respectively，when Train-Of-Four-Ratio returned to 0.5 after surgery.The time TOFR to 1.0， the ratio of successful reversal within 10 min and postoperative nausea and vomiting after surgery 6 h of each group were compared.Result：The time TOFR to 1.0 in the observation group 3 was significantly shorter than those in the control group and the observation group 1，2；the ratio of successful reversal within 10 min was significantly higher than those of the control group and the observation group 1，2，the differences were statistically significant(P<0.05).There were no statistical differences in the time TOFR to 1.0 and the ratio of successful reversal within 10 min between the observation group 1，2 and the control group.There were no statistical differences in the incidence of nausea and vomiting after surgery 6 h(P>0.05).Conclusion：The dose-effect of Neostigmine antagonizing Cistracurium residual paralysis in elderly patients after laparoscopic cholecystectomy are significant and safe and reliable.
【Key words】 Laparoscopic cholecystectomy； Neostigmine； Cistracurium； Residual Paralysis effect
First-author’s address：The Second People’s Hospital of Shenzhen， Shenzhen 518035，China
doi：10.3969/j.issn.1674-4985.2018.15.012, http://www.100md.com(史嘉华 陈志聪 陈剑明)