腹腔镜联合胆道镜手术治疗胆囊结石合胆总管结石对胃泌素族激素及肠黏膜屏障的影响研究(1)
【摘要】 目的：探究腹腔镜联合胆道镜手术治疗胆囊结石合并胆总管结石对胃泌素族激素及肠黏膜屏障的影响研究。方法：选取2014年10月-2017年9月期间本院收治的80例胆囊结石合并胆总管结石患者为研究对象，按照随机数字表法将其分为对照组和观察组，各40例。对照组进行常规开腹手术治疗，观察组则以腹腔镜联合胆道镜治疗。比较两组患者手术前后的餐前及餐后胃泌素族激素及肠黏膜屏障指标。结果：两组患者手术前的餐前及餐后胃泌素族激素及肠黏膜屏障指标比较，差异均无统计学意义(P>0.05)；手术后观察组的餐前及餐后GAS、MTL均高于对照组，CCK及肠黏膜屏障指标均低于对照组，差异均有统计学意义(P<0.05)。结论：腹腔镜联合胆道镜手术治疗胆囊结石合并胆总管结石对患者胃泌素族激素及肠黏膜屏障的不良影响相对更小，更有助于患者术后胃肠功能的恢复。
【关键词】 腹腔镜联合胆道镜治疗； 胆囊结石合并胆总管结石； 胃泌素族激素； 肠黏膜屏障
【Abstract】 Objective：To investigate the effect of laparoscopy combined with choledochoscopy on gastrin hormones and intestinal mucosal barrier in patients with cholecystolithiasis and choledocholithiasis.Method：A total of 80 patients with cholecystolithiasis and choledocholithiasis from October 2014 to September 2017 in our hospital were selected as the study objects.According to the random number table method，they were divided into control group and observation group，40 cases in each group.The control group was treated with routine laparotomy，the observation group was treated with laparoscopy combined with choledochoscopy.The gastrin hormones before and after the meal and intestinal mucosal barrier indexes of two groups before and after operation were compared.Result：The gastrin hormones before and after the meal and intestinal mucosal barrier indexes of two groups before operation were compared，the differences were not statistically significant(P>0.05)，GAS and MTL before and after the meal of the observation group after operation were higher than those of the control group，CCK and intestinal mucosal barrier indexes were lower than those of the control group，the differences were statistically significant(P<0.05).Conclusion：Laparoscopy combined with choledochoscopy in the treatment of cholecystolithiasis combined with choledocholithiasis has less adverse effects on gastrin hormones and intestinal mucosal barrier and is more helpful to the recovery of postoperative gastrointestinal function.
【Key words】 Laparoscopy and choledochoscopy； Cholecystolithiasis combined with choledocholithiasis；
Gastrin hormones； Intestinal mucosal barrier
First-author’s address：Dafeng Hospital in Chaoyang District of Shantou City，Shantou 515154，China
doi：10.3969/j.issn.1674-4985.2018.15.017
膽囊结石是临床常见病，而胆总管结石在胆囊结石患者中较为多见，故临床中关于胆囊结石合并胆总管结石的手术治疗研究多见[1-2]，而随着临床对微创治疗需求的提升及微创治疗技术的发展完善，经验的积累丰富，临床应用率不断提升。腹腔镜联合胆道镜治疗是在本病患者中应用较多的一类微创治疗方式，其临床疗效日益提升[3]，但是对胃肠道功能状态，尤其是术后恢复效果与速度的影响研究少见。因此本研究将腹腔镜联合胆道镜治疗胆囊结石合并胆总管结石对患者胃泌素族激素及肠黏膜屏障的影响进行探究，现报道如下。, 百拇医药(周伟洲 罗泽斌 杨贤杰)
【关键词】 腹腔镜联合胆道镜治疗； 胆囊结石合并胆总管结石； 胃泌素族激素； 肠黏膜屏障
【Abstract】 Objective：To investigate the effect of laparoscopy combined with choledochoscopy on gastrin hormones and intestinal mucosal barrier in patients with cholecystolithiasis and choledocholithiasis.Method：A total of 80 patients with cholecystolithiasis and choledocholithiasis from October 2014 to September 2017 in our hospital were selected as the study objects.According to the random number table method，they were divided into control group and observation group，40 cases in each group.The control group was treated with routine laparotomy，the observation group was treated with laparoscopy combined with choledochoscopy.The gastrin hormones before and after the meal and intestinal mucosal barrier indexes of two groups before and after operation were compared.Result：The gastrin hormones before and after the meal and intestinal mucosal barrier indexes of two groups before operation were compared，the differences were not statistically significant(P>0.05)，GAS and MTL before and after the meal of the observation group after operation were higher than those of the control group，CCK and intestinal mucosal barrier indexes were lower than those of the control group，the differences were statistically significant(P<0.05).Conclusion：Laparoscopy combined with choledochoscopy in the treatment of cholecystolithiasis combined with choledocholithiasis has less adverse effects on gastrin hormones and intestinal mucosal barrier and is more helpful to the recovery of postoperative gastrointestinal function.
【Key words】 Laparoscopy and choledochoscopy； Cholecystolithiasis combined with choledocholithiasis；
Gastrin hormones； Intestinal mucosal barrier
First-author’s address：Dafeng Hospital in Chaoyang District of Shantou City，Shantou 515154，China
doi：10.3969/j.issn.1674-4985.2018.15.017
膽囊结石是临床常见病，而胆总管结石在胆囊结石患者中较为多见，故临床中关于胆囊结石合并胆总管结石的手术治疗研究多见[1-2]，而随着临床对微创治疗需求的提升及微创治疗技术的发展完善，经验的积累丰富，临床应用率不断提升。腹腔镜联合胆道镜治疗是在本病患者中应用较多的一类微创治疗方式，其临床疗效日益提升[3]，但是对胃肠道功能状态，尤其是术后恢复效果与速度的影响研究少见。因此本研究将腹腔镜联合胆道镜治疗胆囊结石合并胆总管结石对患者胃泌素族激素及肠黏膜屏障的影响进行探究，现报道如下。, 百拇医药(周伟洲 罗泽斌 杨贤杰)