血清hs—CRP和BNP水平与心脏瓣膜病合并心衰程度的相关性分析(1)
【摘要】 目的：探讨血清超敏C-反应蛋白(hs-CRP)和B型脑钠肽(BNP)水平与心脏瓣膜病(VHD)合并心力衰竭程度的相关性。方法：选取2017年7月-2018年1月本院收治的VHD合并心力衰竭患者40例为研究组，并按照美国纽约心脏病协会(NYHA)制定的分级方案将其分为Ⅰ～Ⅳ级，另选取同期来院的健康体检者20例为健康对照组。比较两组BNP、hs-CRP水平，比较不同NYHA分级的BNP、hs-CRP水平，分析血清hs-CRP和BNP水平与NYHA心功能分级的相关性。结果：研究组血清hs-CRP和BNP水平均高于健康对照组，比较差异均有统计学意义(P<0.05)；不同等级间血清hs-CRP和BNP水平比较，差异均有统计学意义(P<0.05)；NYHA心功能分级与hs-CRP、BNP均呈正相关(P<0.05)。结论：随着VHD合并心力衰竭患者心力衰竭程度的增加，血清hs-CRP和BNP水平逐渐升高，血清hs-CRP和BNP联合检测对评估VHD合并心力衰竭患者的病情发展、临床诊治和预后评估有显著临床意义。
【关键词】 心脏瓣膜病； 心力衰竭； 超敏C-反应蛋白； B型脑钠肽
, http://www.100md.com
【Abstract】 Objective：To investigate the correlation between serum high sensitive C-reactive protein
(hs-CRP) and type B brain natriuretic peptide(BNP) levels and valvular heart disease(VHD) complicated with the degree of heart failure.Method：A total of 40 patients with VHD complicated with heart failure from July 2017 to January 2018 were selected as study group，and according to the classification scheme formulated by New York heart association(NYHA)，they were divided into grade Ⅰ-Ⅳ，and another 20 healthy people who came to the hospital in the same period were selected as healthy control group.The levels of BNP and hs-CRP in two groups were compared，the levels of BNP and hs-CRP in different NYHA grades were compared，and the correlation between serum hs-CRP and BNP levels and NYHA cardiac function classification was analyzed.Result：The levels of serum hs-CRP and BNP in study group were higher than those of healthy control group，the differences were statistically significant(P<0.05).The levels of serum hs-CRP and BNP in different grades of cardiac function were compared，the differences were statistically significant(P<0.05).NYHA cardiac function classification was positively correlated with hs-CRP and BNP(P<0.05).Conclusion：With the increase of VHD with heart failure，the levels of serum hs-CRP and BNP increased gradually，and the combined detection of serum hs-CRP and BNP has significant clinical significance in evaluating the development，clinical diagnosis and prognosis of patients with VHD complicated with heart failure.
, 百拇医药
【Key words】 Valvular heart disease； Heart failure； Hypersensitivity C-reactive protein； Type B brain natriuretic peptide
First-author’s address：Maonan District People’s Hospital，Maoming 525011，China
doi：10.3969/j.issn.1674-4985.2018.15.037
心臟瓣膜病(Valvular Heart Disease，VHD)是临床常见的心脏疾病之一，好发于老年人群[1]。随着病情的发展，VHD患者可能出现心功能失代偿，加上血流动力学的改变，造成心脏超负荷，最终演变为心力衰竭[2-3]。近年来的研究显示，B型脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)与多种心血管疾病的发生发展有密切关系[4-5]，但是关于血清, 百拇医药(覃毅华 杨金文 吕伟林)
【关键词】 心脏瓣膜病； 心力衰竭； 超敏C-反应蛋白； B型脑钠肽
, http://www.100md.com
【Abstract】 Objective：To investigate the correlation between serum high sensitive C-reactive protein
(hs-CRP) and type B brain natriuretic peptide(BNP) levels and valvular heart disease(VHD) complicated with the degree of heart failure.Method：A total of 40 patients with VHD complicated with heart failure from July 2017 to January 2018 were selected as study group，and according to the classification scheme formulated by New York heart association(NYHA)，they were divided into grade Ⅰ-Ⅳ，and another 20 healthy people who came to the hospital in the same period were selected as healthy control group.The levels of BNP and hs-CRP in two groups were compared，the levels of BNP and hs-CRP in different NYHA grades were compared，and the correlation between serum hs-CRP and BNP levels and NYHA cardiac function classification was analyzed.Result：The levels of serum hs-CRP and BNP in study group were higher than those of healthy control group，the differences were statistically significant(P<0.05).The levels of serum hs-CRP and BNP in different grades of cardiac function were compared，the differences were statistically significant(P<0.05).NYHA cardiac function classification was positively correlated with hs-CRP and BNP(P<0.05).Conclusion：With the increase of VHD with heart failure，the levels of serum hs-CRP and BNP increased gradually，and the combined detection of serum hs-CRP and BNP has significant clinical significance in evaluating the development，clinical diagnosis and prognosis of patients with VHD complicated with heart failure.
, 百拇医药
【Key words】 Valvular heart disease； Heart failure； Hypersensitivity C-reactive protein； Type B brain natriuretic peptide
First-author’s address：Maonan District People’s Hospital，Maoming 525011，China
doi：10.3969/j.issn.1674-4985.2018.15.037
心臟瓣膜病(Valvular Heart Disease，VHD)是临床常见的心脏疾病之一，好发于老年人群[1]。随着病情的发展，VHD患者可能出现心功能失代偿，加上血流动力学的改变，造成心脏超负荷，最终演变为心力衰竭[2-3]。近年来的研究显示，B型脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)与多种心血管疾病的发生发展有密切关系[4-5]，但是关于血清, 百拇医药(覃毅华 杨金文 吕伟林)
参见：首页 > 医疗版 > 疾病专题 > 心血管科 > 心力衰竭