CNPY2在胃癌中的表达及其与侵袭转移、微血管密度的关系(3)
綜上，CNPY2在胃癌组织中表达上调，可能通过血管生成作用在胃癌的侵袭转移中发挥重要作用，有望成为胃癌研究的有效预后因子和潜在基因靶点。
参考文献
[1] Chen W，Zhang R，Baade P D，et al.Cancer statistics in China 2015[J].CA Cancer J Clin，2016，6(2)：115-132.
[2] Kankeu Fonkoua L，Yee N S.Molecular Characterization of Gastric Carcinoma：Therapeutic Implications for Biomarkers and Targets[J].Biomedicines，2018，6(1)：E32.
[3] Olsen J J，Pohl S ?，Deshmukh A，et al.The Role of Wnt Signalling in Angiogenesis[J].Clin Biochem Rev，2017，38(3)：131-142.
, 百拇医药
[4] Draoui N，de Zeeuw P，Carmeliet P.Angiogenesis revisited from a metabolic perspective：role and therapeutic implications of endothelial cell metabolism[J].Open Biol，2017，7(12)：170219.
[5] Guo J，Zhang Y，Mihic A，et al.A Secreted Protein (Canopy 2，CNPY2) Enhances Angiogenesis and Promotes Smooth Muscle Cell Migration and Proliferation[J].Cardiovascular Research，2015，105(3)：383-393.
[6] Taniguchi H，Ito S，Ueda T，et al.CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53[J].Biochem Biophys Res Commun，2017，485(2)：267-271.
, 百拇医药
[7] Hatta K，Guo J，Ludke A，et al.Expression of CNPY2 in mouse tissues：quantification and localization[J].PLoS One，2014，9(11)：e111370.
[8] Ito S，Ueda T，Ueno A，et al.A genetic screen in Drosophila for regulators of human prostate cancer progression[J].Biochem Biophys Res Commun，2014，451(4)：548-555.
[9] Barasch N，Gong X，Kwei K A，et al.Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma[J].PLoS One，2017，12(2)：e0171265.
, http://www.100md.com
[10] Guo J，Mihic A，Wu J，et al.Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy[J].Eur Heart J，2015，36(37)：2530-2540.
[11] Ammendola M，Sacco R，Vescio G，et al.Tryptase mast cell density，protease-activated receptor-2 microvascular density，and classical microvascular density evaluation in gastric cancer patients undergoing surgery：possible translational relevance[J].Therap Adv Gastroenterol，2017，10(4)：353-360.
, http://www.100md.com
[12] Xue J，Wu X L，Huang X T，et al.Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance[J].Asian Pac J Trop Med，2017，10(1)：98-101.
[13] Do H T，Tselykh T V，M?kel? J，et al.Fibroblast growth factor-21(FGF21) regulates low-density lipoprotein receptor(LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)[J].J Biol Chem，2012，287(16)：12602-12611., http://www.100md.com(冯芳 肖虹)
参考文献
[1] Chen W，Zhang R，Baade P D，et al.Cancer statistics in China 2015[J].CA Cancer J Clin，2016，6(2)：115-132.
[2] Kankeu Fonkoua L，Yee N S.Molecular Characterization of Gastric Carcinoma：Therapeutic Implications for Biomarkers and Targets[J].Biomedicines，2018，6(1)：E32.
[3] Olsen J J，Pohl S ?，Deshmukh A，et al.The Role of Wnt Signalling in Angiogenesis[J].Clin Biochem Rev，2017，38(3)：131-142.
, 百拇医药
[4] Draoui N，de Zeeuw P，Carmeliet P.Angiogenesis revisited from a metabolic perspective：role and therapeutic implications of endothelial cell metabolism[J].Open Biol，2017，7(12)：170219.
[5] Guo J，Zhang Y，Mihic A，et al.A Secreted Protein (Canopy 2，CNPY2) Enhances Angiogenesis and Promotes Smooth Muscle Cell Migration and Proliferation[J].Cardiovascular Research，2015，105(3)：383-393.
[6] Taniguchi H，Ito S，Ueda T，et al.CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53[J].Biochem Biophys Res Commun，2017，485(2)：267-271.
, 百拇医药
[7] Hatta K，Guo J，Ludke A，et al.Expression of CNPY2 in mouse tissues：quantification and localization[J].PLoS One，2014，9(11)：e111370.
[8] Ito S，Ueda T，Ueno A，et al.A genetic screen in Drosophila for regulators of human prostate cancer progression[J].Biochem Biophys Res Commun，2014，451(4)：548-555.
[9] Barasch N，Gong X，Kwei K A，et al.Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma[J].PLoS One，2017，12(2)：e0171265.
, http://www.100md.com
[10] Guo J，Mihic A，Wu J，et al.Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy[J].Eur Heart J，2015，36(37)：2530-2540.
[11] Ammendola M，Sacco R，Vescio G，et al.Tryptase mast cell density，protease-activated receptor-2 microvascular density，and classical microvascular density evaluation in gastric cancer patients undergoing surgery：possible translational relevance[J].Therap Adv Gastroenterol，2017，10(4)：353-360.
, http://www.100md.com
[12] Xue J，Wu X L，Huang X T，et al.Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance[J].Asian Pac J Trop Med，2017，10(1)：98-101.
[13] Do H T，Tselykh T V，M?kel? J，et al.Fibroblast growth factor-21(FGF21) regulates low-density lipoprotein receptor(LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)[J].J Biol Chem，2012，287(16)：12602-12611., http://www.100md.com(冯芳 肖虹)
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