同型半胱氨酸联合P、β—hCG及E2对妊娠早期流产结局的预测(1)
【摘要】 目的：探讨先兆流产孕妇孕早期血清同型半胱氨酸(Hcy)、孕酮(P)、人绒毛膜促性腺激素(β-hCG)、雌二醇(E2)水平对妊娠結局的预测价值。方法：选取2017年3月-2018年3月在本院就诊自然受孕的先兆流产孕妇98例，依据妊娠结局将其分成继续妊娠组(n=58)和妊娠失败组(n=40)，另取同期在本院就诊的正常妊娠者为对照组(n=50)。三组分别于孕第6、8、10周检测血清P、β-hCG、E2、Hcy，观察各指标水平以及各项指标对早期先兆流产结局的影响。结果：第6、8周，继续妊娠组、妊娠失败组血清P、β-hCG、E2水平均明显低于对照组，且妊娠失败组均低于继续妊娠组，比较差异均有统计学意义(P<0.05)；第10周，妊娠失败组血清P、β-hCG、E2水平均低于对照组和继续妊娠组(P<0.05)，但继续妊娠组与对照组比较差异均无统计学意义(P>0.05)；第6、8、10周，对照组与继续妊娠组血清Hcy水平比较差异均无统计学意义(P>0.05)；而妊娠失败组血清Hcy水平均明显高于对照组与继续妊娠组，比较差异均有统计学意义(P<0.05)。结论：血清Hcy联合P、β-hCG以及E2可有效地预测早期先兆流产结局，值得临床推广使用。
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【关键词】 先兆流产； 同型半胱氨酸； β-hCG； 孕酮； 雌二醇
【Abstract】 Objective：To explore the predictive value of serum levels of homocysteine(Hcy)，progesterone(P)，human chorionic gonadotropin(β-hCG) and estradiol(E2) in early pregnancy of threatened abortion pregnant women.Method：A total of 98 cases of threatened abortion with natural pregnancy in our hospital from March 2017 to March 2018 were selected.According to pregnancy outcome，they were divided into continued pregnancy group(n=58) and failed pregnancy group(n=40).The normal pregnant women who admitted to our hospital in the same period were taken as control group(n=50).The serum levels of P，β-hCG，E2 and Hcy were detected in three groups at 6th，8th，10th weeks of gestation，the effects of each index and its indicators on the outcome of early threatened abortion were observed.Result：At 6th and 8th weeks，the levels of serum P，β-hCG and E2 in continued pregnancy group and failed pregnancy group were significantly lower than those of control group，and those in failed pregnancy group were lower than those of continued pregnancy group，the differences were statistically significant(P<0.05).At 10th weeks，the levels of serum P，β-hCG and E2 in failed pregnancy group were lower than those of control group and continued pregnancy group(P<0.05)，but continued pregnancy group compared with control group，the differences were not statistically significant(P>0.05).At 6th，8th，10th weeks，the Hcy levels in control group and continue pregnancy group were compared，the differences were not statistically significant(P>0.05)，the serum Hcy levels in failed pregnancy group were significantly higher than those of control group and continued pregnancy group，the differences were statistically significant(P<0.05).Conclusion：Serum Hcy combined with P，β-hCG and E2 can effectively predict the outcome of early threatened abortion，which is worthy of clinical application.
【Key words】 Threatened abortion； Homocysteine； β-hCG； Progesterone； Estradiol, 百拇医药(冯书梅 刘志辉 周艳荷)
, http://www.100md.com
【关键词】 先兆流产； 同型半胱氨酸； β-hCG； 孕酮； 雌二醇
【Abstract】 Objective：To explore the predictive value of serum levels of homocysteine(Hcy)，progesterone(P)，human chorionic gonadotropin(β-hCG) and estradiol(E2) in early pregnancy of threatened abortion pregnant women.Method：A total of 98 cases of threatened abortion with natural pregnancy in our hospital from March 2017 to March 2018 were selected.According to pregnancy outcome，they were divided into continued pregnancy group(n=58) and failed pregnancy group(n=40).The normal pregnant women who admitted to our hospital in the same period were taken as control group(n=50).The serum levels of P，β-hCG，E2 and Hcy were detected in three groups at 6th，8th，10th weeks of gestation，the effects of each index and its indicators on the outcome of early threatened abortion were observed.Result：At 6th and 8th weeks，the levels of serum P，β-hCG and E2 in continued pregnancy group and failed pregnancy group were significantly lower than those of control group，and those in failed pregnancy group were lower than those of continued pregnancy group，the differences were statistically significant(P<0.05).At 10th weeks，the levels of serum P，β-hCG and E2 in failed pregnancy group were lower than those of control group and continued pregnancy group(P<0.05)，but continued pregnancy group compared with control group，the differences were not statistically significant(P>0.05).At 6th，8th，10th weeks，the Hcy levels in control group and continue pregnancy group were compared，the differences were not statistically significant(P>0.05)，the serum Hcy levels in failed pregnancy group were significantly higher than those of control group and continued pregnancy group，the differences were statistically significant(P<0.05).Conclusion：Serum Hcy combined with P，β-hCG and E2 can effectively predict the outcome of early threatened abortion，which is worthy of clinical application.
【Key words】 Threatened abortion； Homocysteine； β-hCG； Progesterone； Estradiol, 百拇医药(冯书梅 刘志辉 周艳荷)
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