妊娠期高血压患者抗磷脂抗体水平与妊娠结局的关系研究(1)
【摘要】 目的：研究妊娠期高血壓(HDCP)患者抗心磷脂抗体(ACA)及抗β2-糖蛋白1(β2-GP1)抗体水平与妊娠结局的关系，深入探讨抗磷脂抗体(APA)在HDCP发病中的作用，为临床预防及治疗HDCP提供新的理论依据。方法：选择在本院接受常规产检的妊娠期高血压疾病孕妇，采用酶联免疫吸附法(ELISA)检测孕妇ACA及抗β2-GP1抗体水平，根据ELISA法检测结果分组，观察组A为仅ACA阳性孕妇，观察组B仅抗β2-GP1抗体阳性孕妇，对照组为ACA及抗β2-GP1抗体均阴性孕妇，每组均纳入30例。分析三组患者不良妊娠结局，以观察组A和观察组B为对象进行研究，分析APA水平与妊娠结局的相关性，分析不同抗磷脂抗体间相关性。结果：观察A组不良妊娠结局总发生率为46.67%，明显高于观察组A(36.66%)和对照组(10.00%)，三组患者不良妊娠结局比较差异有统计学意义(P<0.05)。观察组A和观察组B两组患者ACA-IgM平均为(11.46±4.51)GPLU/mL、ACA-IgG平均为(9.42±3.51)MPLU/mL、抗β2-GP1抗体平均为(104.63±21.83)U/mL。抗β2-GPI抗体与围产儿死亡呈正相关(P<0.05)，ACA-IgM、ACA-IgG和抗β2-GP1抗体均与早产呈正相关(P<0.05)，ACA-IgM与FGR呈正相关(P<0.05)。HDCP患者的ACA-IgG、ACA-IgM和抗β2-GP1抗体三者两两间均呈正相关(P<0.05)。结论：HDCP患者ACA及抗β2-GP1抗体与不良妊娠结局具有一定相关性，APA水平的检测对预测不良妊娠结局具有一定参考。
【关键词】 妊娠期高血压; 抗心磷脂抗体; 抗β2-GP1抗体; 妊娠结局; 相关性
【Abstract】 Objective：To study the relationship between antiphospholipid antibody(ACA)and anti beta 2- glycoprotein 1(β2-GP1)antibody level and pregnancy outcome in patients with pregnancy induced hypertension(HDCP)，to explore the role of anti phospholipid antibody(APA)in the pathogenesis of HDCP，and provide a new theoretical basis for the clinical prevention and treatment of HDCP.Method：The maternal ACA and β2-GP1 antibody levels were detected by enzyme linked immunosorbent assay(ELISA)in pregnant women of our hospital.The results were grouped according to the results of ELISA，the observation group A was only ACA positive，the observation group B was only resistant to positive pregnant women with β2-GP1 antibody，and the control group was ACA and β2-GP1 resistance，all negative pregnant women，30 cases in each group.The adverse pregnancy outcomes of the three groups were analyzed.The study was conducted in observation group A and B，the correlation between antiphospholipid antibody level and pregnancy outcome was analyzed，and the correlation between different antiphospholipid antibodies was analyzed.Result：The total incidence of undesirable pregnancy outcome in observation group A was 46.67%，which was significantly higher than that in observation group B(36.66%)and control group(10.00%).There was significant difference in adverse pregnancy outcomes in the three group(P<0.05).The level of ACA-IgM in the two groups of group A and group B was(11.46±4.51)GPLU/mL，ACA-IgG was(9.42±3.51)MPLU/mL andβ2-GP1 was(104.63±21.83)U/Ml，there was a positive correlation between theβ2-GP1 antibody and perinatal mortality(P<0.05);ACA-IgM，ACA-IgG and β2-GP1 antibody were positively correlated with preterm labor(P<0.05);ACA-IgM and FGR were positively correlated(P<0.05).There was a positive correlation between ACA-IgG，ACA-IgM andβ2-GP1 antibody in HDCP patients(P<0.05).Conclusion：There is a certain correlation between ACA andβ2-GP1 antibody in HDCP patients and bad pregnancy outcome.The detection of APA level has a certain reference to the prediction of bad pregnancy outcome., 百拇医药(刘丽园 潘菊英)
【关键词】 妊娠期高血压; 抗心磷脂抗体; 抗β2-GP1抗体; 妊娠结局; 相关性
【Abstract】 Objective：To study the relationship between antiphospholipid antibody(ACA)and anti beta 2- glycoprotein 1(β2-GP1)antibody level and pregnancy outcome in patients with pregnancy induced hypertension(HDCP)，to explore the role of anti phospholipid antibody(APA)in the pathogenesis of HDCP，and provide a new theoretical basis for the clinical prevention and treatment of HDCP.Method：The maternal ACA and β2-GP1 antibody levels were detected by enzyme linked immunosorbent assay(ELISA)in pregnant women of our hospital.The results were grouped according to the results of ELISA，the observation group A was only ACA positive，the observation group B was only resistant to positive pregnant women with β2-GP1 antibody，and the control group was ACA and β2-GP1 resistance，all negative pregnant women，30 cases in each group.The adverse pregnancy outcomes of the three groups were analyzed.The study was conducted in observation group A and B，the correlation between antiphospholipid antibody level and pregnancy outcome was analyzed，and the correlation between different antiphospholipid antibodies was analyzed.Result：The total incidence of undesirable pregnancy outcome in observation group A was 46.67%，which was significantly higher than that in observation group B(36.66%)and control group(10.00%).There was significant difference in adverse pregnancy outcomes in the three group(P<0.05).The level of ACA-IgM in the two groups of group A and group B was(11.46±4.51)GPLU/mL，ACA-IgG was(9.42±3.51)MPLU/mL andβ2-GP1 was(104.63±21.83)U/Ml，there was a positive correlation between theβ2-GP1 antibody and perinatal mortality(P<0.05);ACA-IgM，ACA-IgG and β2-GP1 antibody were positively correlated with preterm labor(P<0.05);ACA-IgM and FGR were positively correlated(P<0.05).There was a positive correlation between ACA-IgG，ACA-IgM andβ2-GP1 antibody in HDCP patients(P<0.05).Conclusion：There is a certain correlation between ACA andβ2-GP1 antibody in HDCP patients and bad pregnancy outcome.The detection of APA level has a certain reference to the prediction of bad pregnancy outcome., 百拇医药(刘丽园 潘菊英)