宫颈癌术后脉管癌栓阳性患者同步放化疗治疗的短期效果及不良反应分析(1)
【摘要】 目的：分析对宫颈癌术后脉管癌栓阳性患者给予同步放化疗治疗的短期效果与不良反应。方法：选择本院2012年6月-2015年6月收治的80例宫颈癌术后脉管癌栓阳性患者作为观察对象，根据治疗方法不同分为对照组与研究组，各40例。对照组行单纯放疗，研究组行同步放化疗。随访3年，观察对比两组1、2、3年的总生存率、盆腔复发率、无进展生存率及不良反应发生情况。结果：研究组随访1、2年盆腔复发率均明显低于对照组(P<0.05);研究组随访3年的盆腔复发率、总生存率及无进展生存率与对照组比较，差异均无统计学意义(P>0.05);研究组胃肠道不良反应发生率高于对照组(P<0.05)。结论：对宫颈癌术后脉管癌栓阳性患者给予同步放化疗能降低盆腔复发率，改善患者近期生存率，但是容易出现胃肠道反应等不良反应，应做好应对措施。
【关键词】 宫颈癌; 短期疗效; 同步放化疗; 脉管癌栓阳性; 不良反应
【Abstract】 Objective：To analyze the short-term effects and adverse reactions of simultaneous radiotherapy and chemotherapy in positive vascular tumor thrombus patients after cervical cancer surgery.Method：80 cases of positive vascular tumor thrombus patients after cervical cancer surgery were selected in our hospital from June 2012 to June 2015 as the observation objects.According to different treatment methods they were divided into control group and study group，40 cases in each group.The control group received simple radiotherapy，the study group received simultaneous radiotherapy and chemotherapy.Followed-up for 3 years，1，2，3 years of overall survival rate，the pelvic recurrence rate，the progression-free survival rate and adverse reactions of the two groups were observed and compared.Result：1 year，2 years of pelvic recurrence rates in the study group were significantly lower than those in the control group(P<0.05).3 years pelvic recurrence rate，3 years overall survival rate and the progression-free survival rate in the study group were compared with the control group，the differences were not statistically significant(P>0.05).The incidence rate of gastrointestinal adverse reactions in the study group was higher than that in the control group(P<0.05).Conclusion：Simultaneous radiotherapy and chemotherapy in the treatment of positive vascular tumor thrombus patients after cervical cancer surgery can reduce the rate of pelvic recurrence，and improve the short-term survival rate of the patients，but it is easy to appear gastrointestinal reaction and other adverse reactions，so countermeasures should be taken.
【Key words】 Cervical cancer; Short-term effect; Simultaneous radiotherapy and chemotherapy; Vascular tumor thrombus positive; Adverse reaction
First-author’s address：Second Clinical Medical College of Ji’nan University，Shenzhen 518020，China
doi：10.3969/j.issn.1674-4985.2019.17.002
宮颈癌是女性常见的恶性肿瘤，中国宫颈癌发病率约为14.6/100 000，且患病人数持续上升，病死率高，危及患者生命安全。手术、化疗和放疗是临床治疗宫颈癌的主要方法，宫颈癌根治性手术是延长患者生存期最直接有效的方法，但是晚期宫颈癌的复发率高，死亡风险高，需联合放化疗进行综合治疗，优化治疗效果[1]。脉管癌栓阳性是指肿瘤临近组织微血管或淋巴管腔内有癌栓，是宫颈癌患者术后复发和转移的危险因素之一，不利于患者的预后。通过临床长期研究发现，以顺铂为基础的术后同步放化疗对提高宫颈癌术后脉管癌栓阳性患者存活率有积极作用[2]。本文就同步放化疗对宫颈癌术后脉管癌栓阳性患者的不良反应与短期疗效进行探讨，现报道如下。, http://www.100md.com(方敏捷 李先明 李壮玲)
【关键词】 宫颈癌; 短期疗效; 同步放化疗; 脉管癌栓阳性; 不良反应
【Abstract】 Objective：To analyze the short-term effects and adverse reactions of simultaneous radiotherapy and chemotherapy in positive vascular tumor thrombus patients after cervical cancer surgery.Method：80 cases of positive vascular tumor thrombus patients after cervical cancer surgery were selected in our hospital from June 2012 to June 2015 as the observation objects.According to different treatment methods they were divided into control group and study group，40 cases in each group.The control group received simple radiotherapy，the study group received simultaneous radiotherapy and chemotherapy.Followed-up for 3 years，1，2，3 years of overall survival rate，the pelvic recurrence rate，the progression-free survival rate and adverse reactions of the two groups were observed and compared.Result：1 year，2 years of pelvic recurrence rates in the study group were significantly lower than those in the control group(P<0.05).3 years pelvic recurrence rate，3 years overall survival rate and the progression-free survival rate in the study group were compared with the control group，the differences were not statistically significant(P>0.05).The incidence rate of gastrointestinal adverse reactions in the study group was higher than that in the control group(P<0.05).Conclusion：Simultaneous radiotherapy and chemotherapy in the treatment of positive vascular tumor thrombus patients after cervical cancer surgery can reduce the rate of pelvic recurrence，and improve the short-term survival rate of the patients，but it is easy to appear gastrointestinal reaction and other adverse reactions，so countermeasures should be taken.
【Key words】 Cervical cancer; Short-term effect; Simultaneous radiotherapy and chemotherapy; Vascular tumor thrombus positive; Adverse reaction
First-author’s address：Second Clinical Medical College of Ji’nan University，Shenzhen 518020，China
doi：10.3969/j.issn.1674-4985.2019.17.002
宮颈癌是女性常见的恶性肿瘤，中国宫颈癌发病率约为14.6/100 000，且患病人数持续上升，病死率高，危及患者生命安全。手术、化疗和放疗是临床治疗宫颈癌的主要方法，宫颈癌根治性手术是延长患者生存期最直接有效的方法，但是晚期宫颈癌的复发率高，死亡风险高，需联合放化疗进行综合治疗，优化治疗效果[1]。脉管癌栓阳性是指肿瘤临近组织微血管或淋巴管腔内有癌栓，是宫颈癌患者术后复发和转移的危险因素之一，不利于患者的预后。通过临床长期研究发现，以顺铂为基础的术后同步放化疗对提高宫颈癌术后脉管癌栓阳性患者存活率有积极作用[2]。本文就同步放化疗对宫颈癌术后脉管癌栓阳性患者的不良反应与短期疗效进行探讨，现报道如下。, http://www.100md.com(方敏捷 李先明 李壮玲)