甲基睾丸素联合肌瘤切除术对子宫肌瘤患者的有效性及患者性激素水平的影响研究(1)
【摘要】 目的：探討甲基睾丸素联合肌瘤切除术对子宫肌瘤患者的有效性及患者性激素水平的影响研究。方法：选取2017年5月-2018年1月本院收治的子宫肌瘤患者共90例，按照随机数字表法将分为对照组与研究组，每组45例。对照组应用肌瘤切除术治疗，研究组在对照组基础上配合药物甲基睾丸素治疗，比较两组治疗前后性激素水平、性生活质量、炎症反应，并发症及复发情况。结果：治疗前，两组雌二醇(E2)、黄体生成素(LH)及促卵泡激素(FSH)比较，差异均无统计学意义(P>0.05);治疗后，研究组E2低于对照组，而LH与FSH水平均高于对照组(P<0.05)。两组治疗前后性唤起、性欲、性高潮、性行为及性心理评分比较，差异均无统计学意义(P>0.05)。治疗前，两组白细胞介素-6(IL-6)、C反应蛋白(CRP)及血清淀粉样蛋白(SAA)水平比较，差异均无统计学意义(P>0.05);治疗后，研究组CRP、SAA及IL-6水平均低于对照组(P<0.05)。两组并发症发生率比较，差异无统计学意义(P>0.05)，研究组1年后复发率明显低于对照组(P<0.05)。结论：采用甲基睾丸素联合肌瘤切除术治疗子宫肌瘤，可降低炎症反应，改善患者性激素水平，不影响性生活质量且不增加并发症，可有效降低术后复发率，值得在临床中进一步推广应用。
【关键词】 甲基睾丸素 肌瘤切除术 子宫肌瘤 性激素 性生活质量 炎症反应
Effect of Methyltestosterone Combined with Myomectomy on the Efficacy and Sex Hormone Level of Patients with Uterine Leiomyoma/SUN Cong. //Medical Innovation of China， 2020， 17(01)： 0-048
[Abstract] Objective： To investigate the effect of Methyltestosterone combined with myomectomy on the efficacy and sex hormone level of patients with uterine leiomyoma. Method： A total of 90 patients with uterine fibroids admitted to our hospital from May 2017 to January 2018 were selected and divided into control group and research group according to the random number table method， 45 cases in each group. The control group was treated with myomectomy， and the research group was treated with Methyltestosterone on the basis of the control group. Sex hormone levels， quality of sexual life， inflammatory response， complications and recurrence before and after treatment were compared between the two groups. Result： Before treatment， there were no significant differences in estradiol (E2)， luteinizing hormone (LH) and follicle-stimulating hormone (FSH) between the two groups (P>0.05). After treatment， E2 in the research group was lower than that in the control group， while LH and FSH levels were higher than those in the control group (P<0.05). There were no statistically significant differences in sexual arousal， libido， orgasm， sexual behavior and psychosexual scores between the two groups before and after treatment (P>0.05). Before treatment， there were no statistically significant differences in interleukin-6 (IL-6)， C reactive protein (CRP) and serum amyloid protein (SAA) between the two groups (P>0.05). After treatment， CRP， SAA and IL-6 levels in the research group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05)， and the recurrence rate after 1 year in the research group was significantly lower than that in the control group (P<0.05). Conclusion： Methyltestosterone combined with myomectomy for the treatment of uterine leiomyoma can reduce the inflammatory response， improve the sex hormone level of patients， do not affect the quality of sexual life and do not increase complications， can effectively reduce the postoperative recurrence rate， which is worthy of further promotion and application in clinical practice., http://www.100md.com(孙聪)
【关键词】 甲基睾丸素 肌瘤切除术 子宫肌瘤 性激素 性生活质量 炎症反应
Effect of Methyltestosterone Combined with Myomectomy on the Efficacy and Sex Hormone Level of Patients with Uterine Leiomyoma/SUN Cong. //Medical Innovation of China， 2020， 17(01)： 0-048
[Abstract] Objective： To investigate the effect of Methyltestosterone combined with myomectomy on the efficacy and sex hormone level of patients with uterine leiomyoma. Method： A total of 90 patients with uterine fibroids admitted to our hospital from May 2017 to January 2018 were selected and divided into control group and research group according to the random number table method， 45 cases in each group. The control group was treated with myomectomy， and the research group was treated with Methyltestosterone on the basis of the control group. Sex hormone levels， quality of sexual life， inflammatory response， complications and recurrence before and after treatment were compared between the two groups. Result： Before treatment， there were no significant differences in estradiol (E2)， luteinizing hormone (LH) and follicle-stimulating hormone (FSH) between the two groups (P>0.05). After treatment， E2 in the research group was lower than that in the control group， while LH and FSH levels were higher than those in the control group (P<0.05). There were no statistically significant differences in sexual arousal， libido， orgasm， sexual behavior and psychosexual scores between the two groups before and after treatment (P>0.05). Before treatment， there were no statistically significant differences in interleukin-6 (IL-6)， C reactive protein (CRP) and serum amyloid protein (SAA) between the two groups (P>0.05). After treatment， CRP， SAA and IL-6 levels in the research group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05)， and the recurrence rate after 1 year in the research group was significantly lower than that in the control group (P<0.05). Conclusion： Methyltestosterone combined with myomectomy for the treatment of uterine leiomyoma can reduce the inflammatory response， improve the sex hormone level of patients， do not affect the quality of sexual life and do not increase complications， can effectively reduce the postoperative recurrence rate， which is worthy of further promotion and application in clinical practice., http://www.100md.com(孙聪)
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